St. Louis Cardinals vs. Milwaukee Brewers Prediction and Picks - September 14, 2025
Use Code WWWC On Sunday, the division-leading Milwaukee Brewers and the St. Louis Cardinals wrap up their series at American Family Field. Milwaukee (90-58) has already clinched the first postseason spot in Major League Baseball and is aiming to stay sharp with October approaching. St. Louis (72-76), meanwhile, is clinging to faint Wild Card hopes and needs a turnaround.
The Brewers have won five of the past seven meetings, including an 8-2 victory Friday to snap a brief skid.
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Somehow they still have a chance
The Cardinals’ late-season slide continued Friday with a fourth straight loss, dropping them to 72-76. The Cardinals are only 3.5 games out of a wild-card spot despite the losing record, but with only 14 games left, there are four teams ahead of them for the final postseason position. While the offense has potential, consistency and power have been lacking. Wilson Contreras leads the team with 20 home runs and 78 RBI.
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Pitching has been a season-long issue, and right-hander Miles Mikolas (7-10, 4.84 ERA) will make the start Sunday. Mikolas has a 3.00 ERA against Milwaukee this year but has struggled overall, particularly on the road. With starters often failing to work deep into games, the bullpen has been overtaxed. St. Louis is 3-7 in its past 10 and slipping out of Wild Card contention.
Brewers have Best record in baseball
Milwaukee’s season has been defined by consistency and pitching depth, particularly since the All-Star break. Christian Yelich leads the offense with 28 homers and 95 RBI. Sal Frelick leads the team with a .294 batting average, followed by Jackson Chourio with 20 home runs. The Brewers rank second in the NL in on-base percentage (.333) and near the top in batting average (.260).
On Sunday, Milwaukee is listed to hand the ball to left-hander José Quintana (11-6, 3.88 ERA). Although he has been steady overall, he owns a 5.79 ERA against St. Louis this season. The Brewers’ defense and late-inning bullpen strength remain reliable, helping cover mistakes and preserve leads. If Milwaukee works counts against Mikolas, who is prone to hard contact, the Brewers have a strong chance to secure another win at home.
Brewers vs Cardinals Prediction
Moneyline prediction for Brewers vs. Cardinals
- Brewers ML -168 (3 units)
Milwaukee has the edge in nearly every category. Quintana’s season-long numbers, paired with a dominant bullpen, give the Brewers the advantage over Mikolas and a struggling St. Louis staff. The Brewers’ lineup is patient and balanced, while the Cardinals have been unable to string together consistent rallies. Milwaukee is the right side.
Total Prediction for Cardinals vs. Brewers
- Under 9
With two veteran pitchers and both offenses inconsistent, the under nine runs stands out. Quintana and Mikolas are capable of limiting big innings, and Milwaukee often relies on its bullpen to close out low-scoring games. Unless one team jumps early, runs should be tough to come by, especially late against quality relievers.
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