St. Louis Cardinals vs. San Francisco Giants Picks and Prediction for Tuesday, September 23, 2025
Use Code WWWC St. Louis Cardinals (76-80) vs. San Francisco Giants (77-79)
The ultimate week of the 2025 Major League Baseball season goes on Tuesday, September 23, with the St. Louis Cardinals taking on the San Francisco Giants in the National League showdown at Oracle Park in San Francisco, CA, and we’ve got you covered with our Cardinals vs. Giants prediction.
St. Louis and San Francisco continue their three-game series at Oracle Park, and Monday’s opener has been excluded from the analysis. They already met each other earlier this month, and the Cardinals took two out of three against the Giants in Saint Louis.
Let’s take a closer look at this Cardinals vs. Giants prediction, one of our MLB picks for Tuesday’s slate. The first pitch at Oracle Park is set at 9:45 PM ET, and the Giants are -190 favorites with a total of 7.5 runs.
The Cardinals need more from Andre Pallante
The St. Louis Cardinals went 3-3 last week. After dropping two out of three games against the Cincinnati Reds, the Cardinals took two out of three from the mighty Milwaukee Brewers. St. Louis was four games behind the final wild-card spot in the National League on Monday morning, and soon, the Cards will be eliminated from playoff contention.
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The Cardinals have only won four of their previous 12 games overall. During that stretch, the Cardinals have scored 45 runs on a .234/.313/.333 triple-slash, while their bullpen has recorded a 4.17 ERA, 1.52 WHIP, and a .258 batting average against.
Andre Pallante is expected to toe the slab at Oracle Park on Tuesday night. The 27-year-old right-hander is 6-15 with a pedestrian 5.29 ERA and 1.44 WHIP in 30 starts (160 innings pitched) this season. He’s struggled a lot lately, allowing four or more runs in seven of his previous eight starts.
Pallante is 1-0 with a 4.95 ERA in three career starts and four relief appearances against the Giants. He met them 17 days ago and threw six innings of a two-run, five-hit ball in a no-decision. The current Giants are 20-for-56 with five doubles and three home runs against Pallante.
The Giants are in dire straits
The San Francisco Giants went 2-5 last week, ruining their playoff chances. They lost a three-game series against the Arizona Diamondbacks and a four-game set against the Los Angeles Dodgers. San Francisco was three games behind the final wild card in the National League on Monday morning, and the Giants need a miracle to make it to the postseason.
The Giants have lost eight of their previous 11 games overall. They’ve scored 40 runs on a horrendous .167/.268/.251 slash line during that stretch, while the Giants' bullpen has amassed a 5.48 ERA, 1.63 WHIP, and a .278 batting average against.
Logan Webb is projected to get the starting call on Tuesday. The 28-year-old righty carries a 14-11 record with a 3.27 ERA and 1.24 WHIP in 32 starts (195.2 IP) in 2025. He’s had one bad start over his previous seven outings, posting a 3.00 ERA and 2.81 FIP during that stretch (42 IP).
Webb is 3-3 with a 5.30 ERA in seven career starts against the Cardinals. He’ll meet St. Louis for the first time in 2025, and the current Cardinals are 16-for-51 with a double and a home run against Webb.
Cardinals vs. Giants Pick
Spread Pick for Cardinals vs. Giants
- San Francisco Giants -1.5 (5 units)
The Giants have an advantage over the Cardinals on the mound, and I expect San Francisco to get the job done, even though the Giants’ lineup has struggled a lot lately. Andre Pallante cannot be trusted. He’s gone 0-8 with a 7.12 ERA and 5.70 FIP in his last nine starts.
Logan Webb is 5-3 with a 3.15 ERA and 2.70 FIP in his last nine starts. He’ll outpitch Pallante and lift the Giants over the Cardinals, whose lineup hasn’t impressed either. The Cards are hitting .240/.335/.353 against the righties in the past 10 days.
Over/Under Pick for Cardinals vs. Giants
- Over 7.5 (5 units)
Although the Giants have accounted for a hideous .467 OPS and 39 wRC+ against the righties in the last 10 days, I expect them to get to Andre Pallante. And with both bullpens struggling to pitch at a high level lately, I have to go with the over.
The line sits at 7.5 runs because of Logan Webb and the Giants’ offensive woes. Still, six of San Francisco’s previous nine games overall have produced at least nine runs in total. I think that both St. Louis and San Francisco will score a few runs when the bullpens take over.
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