St. Louis Cardinals vs. Seattle Mariners Picks and Prediction, Wednesday, September 10, 2025
On Wednesday, the St. Louis Cardinals will play the Seattle Mariners at T-Mobile Park, and we have you ready to go with our Cardinals vs. Mariners prediction. First pitch is at 6:40 p.m. PT.
Seattle is a -220 moneyline favorite, and the game total is 7.5 runs scored.
These ballclubs are playing for the first time this season. The Mariners are 6-4 in their last ten matchups with the Redbirds, and the under was 5-4-1 in those ten games. If you want the Cardinals vs. Mariners prediction, read on and check out our MLB Predictions to beat the sportsbooks!
*Article published before the conclusion of Tuesday's game.
Sign Up for Winners and Whiners News Alerts, Get Free Picks and Discounts
Subscribe Now
Cardinals are still in the Wild Card race
St. Louis (72-73 SU, 70-75 RL, and 72-65-8 O/U) won two of three games against San Francisco in its previous series. The Cardinals are 6-4 in their last ten games (the under went 6-4).
St. Louis will turn to right-hander Michael McGreevy tomorrow against Seattle. In his last start (4.0 IP loss to the Giants), the 25-year-old allowed six runs on nine hits, including two homers. He is 6-3 with a 4.68 ERA and 1.26 WHIP in 13 appearances (73.0 IP) this season, including 4-0 with a 2.70 ERA and 1.03 WHIP in five road starts (30.0 IP).
The Cards are hovering right around .500, but they are 17 games out of the NL Central division race and 4.5 games out of the Wild Card chase. Like the Giants, they have struggled since the All-Star break, compiling a 21-26 record. Can they at least finish the season with a winning record?
St. Louis Cardinals Baseball Injury Report: No new injuries to report for Wednesday's game against the Mariners.
Seattle has its sights set on the AL West title
Seattle (76-68 SU, 60-84 RL, and 78-60-6 O/U) won two of three games against Atlanta in its previous series. The Mariners are 4-6 in their last ten games (the under was 6-4).
Seattle is expected to start right-hander Logan Gilbert tomorrow against the Cardinals. In his last outing, the 28-year-old surrendered one run on five hits with seven strikeouts in six innings against the Braves. He is 4-6 with a 3.41 ERA and 1.02 WHIP in 21 starts (109.2 IP) this season, including 3-2 with a 2.15 ERA and 0.70 WHIP in 11 home starts (58.2 IP).
Seattle was among the most disappointing baseball teams last year, as it wasted a fantastic pitching rotation (2.85 ERA and a .205 OBA) with an inability to provide run support. The Mariners ranked 20th in runs scored in 2024, averaging 4.1 per game. Close losses were too common for M's fans, but they appear to have turned it around this year. Seattle has been more productive at the plate in 2025, ranking 11th in MLB in runs scored (4.66 per game), and has stayed competitive on the mound. Can they finish strong to steal the division from Houston?
Seattle Mariners Baseball Injury Report: No new injuries for Wednesday's game against St. Louis.
Cardinals vs. Mariners Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Run Line Pick for Cardinals vs. Mariners
- Seattle Run Line (5 Units)
Betting Trend: The Cardinals have only covered the run line in 56.9 percent of their games as road underdogs this season, the fifth-lowest RL winning percentage in MLB.
The Mariners have a significant pitching advantage on Wednesday with Gilbert on the mound. The veteran righty has been tough to hit at T-Mobile Park, holding opponents to a .141 batting average. He has also fanned 88 batters in less than 60 innings at home. Gilbert also enters this matchup with momentum, as he has allowed only five runs in his previous three starts overall, racking up 26 Ks in 18 combined innings. Current St. Louis hitters have a .125 BA and a 44.4% strikeout percentage in 18 plate appearances against him. McGreevy has potential, but he is coming off a rough outing, and he has struggled since the All-Star break (4.88 ERA and .295 opponent BA).
Over/Under Pick for Cardinals vs. Mariners
- Under 7.5 (4 Units)
The Redbirds rank last in MLB in wRC+ (61) over the last week and will face a challenging starter in Gilbert on Wednesday. I don't like their odds of scoring more than a couple of runs against the Mariners' starter, as they also rank 24th in wRC+ against right-handers and 25th in wRC+ on the road this season. McGreevy can also pitch well enough to prevent the total from reaching eight runs. His 2.70 road ERA is impressive, and he'll benefit from playing in a pitcher's ballpark against a lineup that's never faced him. Plus, the Cardinals have a top-five bullpen this year (3.59 ERA and 1.27 WHIP, with 43 HR allowed, the fewest in MLB).
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $150
