Tampa Bay Rays vs. Baltimore Orioles Picks and Prediction for Wednesday, September 24th, 2025

By: Adam Rauzino Published 09/24/2025, 10:17 AM ET
Tampa Bay Rays vs. Baltimore Orioles prediciton.
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The Tampa Bay Rays (76-80, 78-78 RL, 69-77-10 O/U) and the Baltimore Orioles (73-83, 78-78 RL, 64-85-7 O/U)Β  resume a three-game series on Wednesday evening, and we have you covered with the prediction. The Rays are sending Shane Baz to the mound. The Orioles will answer with Tyler Wells. The season series is 5-5 entering Tuesday.

Can Baz post his 11th win of the season on Wednesday evening? Check out the Rays vs. Orioles prediction. Nobody does it better when it comes to MLB Picks!

Baz Seeks 11th Win of Season

Shane Baz is on the rubber in this one. Baz was sharp in his previous effort, posting five scoreless innings against Toronto, and secured the win. He has not been able to contain opponents for extended periods. The young righty has been strong this month, conceding two or fewer runs in three of his past five outings and has delivered a shaky 4.99 ERA and a 1.35 WHIP, accompanied by a 10-12 record in 162.1 innings pitched on the season. Baz has kept the Orioles to only two runs (one earned) in 12 career innings.

The Tampa Bay Rays are on the road to end the season. The Rays are going to finish with a record below the .500 mark. There were positives to come out of this losing season, and they could be a contender next year. The Rays won two of four against the Blue Jays last week and were dealt a series loss by the Red Sox this past weekend, squandering 19 runs. The Rays areΒ  35-40 on the road.

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Christopher Morel is having a disappointing season and might not even be a regular player next year. The 26-year-old only has 11 home runs with 31 RBIs on the year. Josh Lowe has just seven RBIs this month. The veteran outfielder has 40 RBIs and a weak .662 OPS on the year.Β  Yandy Diaz has been a tough out against the Orioles this season, posting eight RBIs. The veteran first baseman has a dazzling 1.1 OPS this month and is having another big year, bashing 25 homers with 83 RBIs.Β  Jonathan Aranda has a hand injury and is not expected to play in this series.

Tampa Bay is averaging 4.46 runs on the year, marking them 15th. The pitching is strong, posting a 3.85 ERA, placing them ninth.

Wells Gets the Nod for Baltimore

The Orioles are expected to have Tyler Wells on the mound. Wells came through with a superb effort last week, keeping Chicago to one run in six innings, and was credited with a win. The veteran has only made three starts due to injury. He did not make his season debut un earlier this month and has been sharp, sporting a 2.04 ERA and a 0.62 WHIP complemented by a 2-0 record in 17.2 innings pitched. Wells has not been able to contain Tampa Bay in his career, issuing a poor 5.06 ERA and an 0-3 record in 31.2 innings.

The Baltimore Orioles are having a disastrous season, but injuries have played a part. They could be a playoff team next year. The squad is younger and should see better numbers on the mound next season. The Orioles swept the White Sox last week and were hit with a series loss against the Yankees before this series, conceding 16 runs. The O’s have posted a 37-41 mark at home.

Jackson Holliday was the #1 prospect when he was promoted and could be a breakout player next year. The 21-year-old second baseman has 17 bombs along with 55 RBIs and a mediocre .699 OPS. Gunnar Henderson has netted a sharp .962 OPS against the Rays this season. The star shortstop has bashed 65 RBIs and a strong .785 OPS.Β  Ryan Mountcastle has issued four RBIs in September. The 28-year-old first baseman has managed 33 RBIs and a .651 OPS on the year. Coby Mayo is another young player who could break out at the dish next year. The rookie first baseman has reported 25 RBIs and a .650 OPS.

Baltimore is scoring an average of 4.21 runs on the season, rating them 24th. The pitching staff has issued a 4.60 ERA, pegging them 24th.

Rays vs. Orioles Pick

Spread Pick for Rays vs. Orioles

  • Baltimore Orioles -110 (5 units)

The Tampa Bay Rays have been stumbling down the final stretch, dropping six of their past 10 games. They have especially struggled on the road, where they have dropped four of their past five games. The Baltimore Orioles have won six of their past 10 home games entering Tuesday evening, including a series win against the Dodgers.

Furthermore, Rays pitcher Shane Baz is an inconsistent option and just surrendered five runs in his previous road start. The Rays are not winning games when Baz is on the mound. They have lost in seven of Baz’s past 10 starts. Orioles pitcher Tyler Wells has only made three starts this season due to injury, but has been sharp, keeping the opposition to only four runs in 17.2 innings, resulting in a stingy 2.04 ERA and a 0.62 WHIP.

Over/Under Pick for Rays vs. Orioles

  • Under 8.5 (5 units)

I expect this one to go under. Tampa Bay has scored four or fewer runs in six of its past 10 games. Wells has conceded two or fewer runs in all three of his outings this season.

In addition, Baltimore has also been quiet at the plate, scoring only nine runs in their past five games. Baz posted five scoreless innings against the Blue Jays in his previous outing. Also, Baz has better numbers on the road, issuing a decent 4.05 ERA. In the previous series between these rivals, Baltimore only scored nine runs. The under is a convincing 5-0 in the Orioles' past five games entering Tuesday evening.

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