Tampa Bay Rays vs. Baltimore Orioles, Picks and Prediction, Tuesday, September 23, 2025
Use Code WWWC Tampa Bay (76-80) will be trying to take the series lead when they visit Oriole Park at Camden Yards on Tuesday night to face Baltimore (73-83) in the first game of their three-game series at 6:35 PM. ET. Read on to find out which team picks up the win in this Rays vs. Orioles prediction. When it comes to MLB picks, our MLB Predictions are stellar.
Ryan Pepiot, 11-11, 3.77 ERA, will get the start for the Rays. The Orioles will counter with Dean Kremer, 10-10, 4.39 ERA.
Baltimore and Tampa Bay split their last 10 meetings.
Tampa Bay Going For Second Consecutive Win
The Rays snapped their two-game losing streak with a win over Boston on Sunday, avoiding a three-game sweep in the process. They will try to keep the momentum going and pick up their second straight win when they play on Tuesday.
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Tampa Bay averages 4.46 runs per game, which is 16th in the league. Their .252 batting average is 10th in the league. Their .314 on base percentage is 19th, while their .403 slugging percentage is 13th.
Yandy Diaz leads Tampa Bay with a .302 batting average, while Junior Caminero leads the team with 44 home runs and 108 RBI.
Tampa Bay is giving up 4.15 runs per game, which is 10th in the league. Opponents have a .236 batting average against the Rays, which is eighth in the league. Their 3.85 ERA is ninth, while their 1.21 WHIP is fourth.
In his last start, Pepiot gave up four hits and four runs in 1.2 innings, leading to a 6-5 loss to Toronto. He is 2-2 with a 5.00 ERA in five games against Baltimore.
Baltimore Trying To Snap Two-Game Losing Streak
The Orioles followed up their three-game sweep of the White Sox with three losses in their four-game series against the Yankees. They will try to put an end to the losing streak and pick up their fifth win in their last eight home games when they play on Tuesday.
Baltimore averages 4.21 runs per game, which is 21st in the league. Their .237 batting average is 24th in the league. Their .305 on base percentage is 24th, while their .395 slugging percentage is 20th.
Gunnar Henderson leads Baltimore with a .273 batting average and 65 RBI, while Jackson Holliday leads the team with 17 home runs.
Baltimore is giving up 4.87 runs per game, which is 24th in the league. Opponents have a .259 batting average in the league, which is 26th in the league. Their 4.61 ERA is also 24th, while their 1.37 WHIP is 27th.
In his last start, Kremer gave up four hits and two runs in 5.2 innings, leading to an 8-7 win over the White Sox. He is 4-1 with a 1.83 ERA in 10 games against Tampa Bay.
Rays vs. Orioles Pick
Money Line Pick for Rays vs. Orioles
- Baltimore Orioles ML (4 Units)
The Orioles have won four of their last seven home games, while the Rays have lost four of their last six road games. Baltimore has the edge here because they’ve hit the ball well against right-handers, and they’re going up against Pepiot, who struggled in recent road starts, giving up eight runs in his last three road starts. He gave up 10 runs in three starts against the Orioles this season and will have a hard time slowing them down.
Tampa Bay won’t be as successful offensively because they didn’t hit the ball well in recent road games, and they’re going up against Kremer, who gave up more than one run once in his last three home starts. He has also dominated the Rays, going 4-0 in his last six starts against them, giving up three total runs. He gave up one run in his last four home starts against the Rays and will keep their offense in check. Take Baltimore on the money line.
Over/Under Pick for Rays vs. Orioles
- Under (4 Units)
The Orioles played under the total in their last five games. Baltimore averages 4.21 runs per game and averaged two runs per game in their last three games. They’re batting .239 against right-handers, and they’re facing a starter who gave up four runs in his last three starts. The Rays average 4.46 runs per game and averaged 5.67 runs per game in their last three games. They’re batting .259 against right-handers, and they’re facing a starter who gave up three runs in his last six starts against them. Don't expect these teams to score enough runs to push the score over the total. The Orioles and Rays played under the total in three of their last four meetings.
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