Tampa Bay Rays vs Baltimore Orioles Prediction and Picks - September 25, 2025
Use Code WWWC American League East MLB action on Thursday afternoon, and we have a Tampa Bay Rays vs Baltimore Orioles Prediction locked and loaded. The Rays have not had a good year, going 77-81 so far, while the Orioles have been worse at 74-84. The season series sits at six games apiece. Read on to see our Rays vs Orioles prediction.
Need some winners this baseball season? Check out our Free MLB Picks.
Rays Bounce Back From Loss On Tuesday
Tampa Bay bounced back in a big way Wednesday night, with a 6–2 win over Baltimore that featured power, precision, and a near no-hit bid. Brandon Lowe and Jake Mangum each homered, and the Rays held the Orioles hitless through six innings before Tyler O’Neill broke it up in the seventh. Shane Baz pitched four scoreless frames, and the bullpen—led by Edwin Uceta and Garrett Cleavinger—kept Baltimore off balance until the eighth. Richie Palacios added three hits and a stolen base, while Chandler Simpson and Hunter Feduccia each chipped in with RBI doubles. It was a complete performance that showcased Tampa’s depth and resilience.
Thursday’s matinee marks the final road game of the season for the Rays, and they’ll hand the ball to Drew Rasmussen (10–5, 2.80 ERA), who’s riding a franchise-record streak of 16 consecutive starts allowing five hits or fewer. Rasmussen lasted just three innings in his last outing against Boston, but he’s been dominant overall, especially when working ahead in counts. Tampa Bay’s offense has been streaky, but with Lowe heating up—now with 31 homers—and Mangum providing spark from the bottom of the order, they’ve got enough firepower to pressure Baltimore early. Expect aggressive baserunning and early swings against Cade Povich, who’s struggled with command and fly ball damage.
Get Free $30 Credit for Premium Picks + Exclusive Discounts
Subscribe Now
Defensively, the Rays turned three double plays Wednesday and showed improved infield cohesion, a key factor as they try to close the season on a high note. With postseason hopes long gone, Tampa Bay is playing for pride and roster evaluation. Junior Caminero continues to impress with his glove and bat, and the bullpen remains a strength. If Rasmussen settles in and the bats stay hot, the Rays could leave Camden Yards with a series win and a bit of momentum heading into their final homestand.
Orioles Are Struggling On Offense
Baltimore’s offense went silent for six innings Wednesday night, and by the time Jordan Westburg’s two-run single broke the shutout in the eighth, the damage was done. The Orioles managed just three hits and committed two errors, including a misplay by Tyler O’Neill that extended a Rays rally. Starter Tyler Wells took the loss, allowing three runs on seven hits over four innings. It was a frustrating night for a team that had blanked Tampa Bay 6–0 the night before and looked poised to take control of the series. Instead, they’ll enter Thursday’s finale looking to salvage a split and avoid a fifth loss in seven games.
Cade Povich (3–8, 5.06 ERA) gets the nod for Baltimore, and he’ll need to be sharp against a Rays lineup that’s aggressive early in counts. Povich has shown flashes of swing-and-miss stuff but has struggled with walks and long balls—two areas Tampa Bay exploited Wednesday. Offensively, the Orioles will lean on Gunnar Henderson and Adley Rutschman to set the tone, though both were held hitless in the loss. Westburg has been a steady contributor, and Colton Cowser’s plate discipline could be key in extending innings and getting Rasmussen out of rhythm.
With just four games left in the season, Baltimore is focused on player development and closing strong. Henderson and Rutschman remain foundational pieces, and the bullpen—particularly Yennier Cano and Danny Coulombe—has been reliable despite heavy usage. Thursday’s game offers a chance to reset, especially if the Orioles can jump on Rasmussen early and avoid chasing. A win would not only split the series but send a message heading into the offseason: this team still has fight, even in the standings’ shadows.
Tampa Bay Rays vs Baltimore Orioles Pick
Rays vs Orioles Moneyline Pick
- Tampa Bay -128 (5 Units)
Tampa Bay -128 offers solid value in Thursday’s finale, especially with Drew Rasmussen on the mound and the Rays coming off a sharp 6–2 win. Rasmussen has quietly been one of the most consistent arms in the AL, allowing five hits or fewer in 16 straight starts and posting a 2.80 ERA across 10 wins. He’s backed by a bullpen that’s locked in—Garrett Cleavinger and Edwin Uceta combined for five scoreless innings Wednesday—and a lineup that’s finding rhythm late in the season. Brandon Lowe’s power surge (31 HR) and Jake Mangum’s emergence at the bottom of the order give Tampa Bay a balanced attack, and they’ve now scored 5+ runs in four of their last six games.
Baltimore, meanwhile, has dropped four of its last seven and sends Cade Povich to the hill with a 5.06 ERA and a tendency to struggle early. The Rays are aggressive in the first two innings and could jump on Povich before the Orioles settle in. Baltimore’s lineup has talent, but it’s been streaky—Gunnar Henderson and Adley Rutschman were held hitless Wednesday, and the team managed just three hits overall. With Tampa’s defense turning double plays and Rasmussen’s command trending strong, the Rays are well-positioned to control tempo and close the series with a win. At -128, the price reflects a pitching edge and a team playing with late-season purpose.
Rays vs Orioles Over/Under Pick
- Under 8.5 (4 Units)
Under 8.5 looks sharp in Thursday’s finale, especially with Drew Rasmussen on the mound and both bullpens trending strong. Rasmussen has held opponents to two runs or fewer in five of his last six starts, and Tampa Bay’s relief corps—led by Garrett Cleavinger and Edwin Uceta—just tossed five scoreless innings in Wednesday’s win. Baltimore’s offense has cooled, managing just three hits last night and struggling to generate consistent production outside of Jordan Westburg. Cade Povich has been volatile, but if he can limit early damage and avoid walks, this game could settle into a low-scoring rhythm. With both teams out of playoff contention and focused on player evaluation, expect a tighter, more deliberate pace that favors the under.
Never Tried Winners and Whiners? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code DOLLAR
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
- Check out more MLB predictions
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
