Tampa Bay Rays vs St. Louis Cardinals Picks and Predictions for Saturday, March 28, 2026

By: Cameron Ross Published 03/28/2026, 06:15 AM ET
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The Tampa Bay Rays will be on the road Saturday afternoon for Game 2 of the MLB season with the game inside Busch Stadium in St. Louis, MO, against the Saint Louis Cardinals, and we have you ready to roll with our Tampa Bay vs St. Louis prediction. Tampa Bay comes into game two of the year winless after one game. The Saint Louis Cardinals remained at home Saturday, undefeated after one game, extending a long winning streak back into spring training. Read more about this Milwaukee vs Orlando prediction! Struggling with handicapping? Try our MLB Predictions!

Rays look for their first win of the year

Nick Fortes is leading the Tampa Bay offense after one game with a .750 batting average. Yandy Diaz has a .600 batting average after compiling three hits in five at-bats in game one. Jonathan Aranda and Johnny DeLuca both added two hits and four at-bats in game one. Jonathan Rhonda also led Tampa Bay in game one of the season with one home run and two RBIs in the game.

Drew Rasmussen got the start for Tampa Bay in game one of the season, giving up one run on four hits across 5 innings of work. Ian Seymour came out of the Tampa Bay bullpen as the first reliever, giving up five runs on five hits after recording no outs in the game. Garrett Cleavinger took the loss for Tampa Bay after giving up two runs on two hits in just 1 third of an inning. The final two pitchers of the game for Tampa Bay combined to give up one run on three hits over the final eight outs of the game.

Key Injury Report for Tampa Bay:

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  • Ricardo Genoves (60-Day IL)
  • John Rooney (Day-To-Day)
  • Logan Driscoll (Day-To-Day)
  • Nick Martinez (Day-To-Day)
  • Ryan Peiot (15-Day IL)

Cardinals try to stay perfect

Alec Burleson is leading the Saint Louis offense after one game this season with a .750 batting average after being one of two players with three hits in four at-bats in game one of the year. Nathan Church also chipped in heavily in game one of the season with three hits and four at-bats. JJ Weatherholt and Alec Burleson led Saint Louis in game one of the year with one home run apiece. Nathan Church, JJ Wetherholt, Alec Burleson, and Nolan Gorman carried the Saint Louis offense in game one of the year, driving in two runs apiece.

Matthew Liberatore got the start for the Saint Louis Cardinals in game one of the year, giving up one run on seven hits across 5 innings of work. Matt Svanson came on in relief to give up three runs on three hits after recording only one out. Justin Bruihl gave up two runs on one hit. Chris Roycroft allowed one run on three hits in the game. The final three pitchers of the game gave up no runs on three hits over the final three innings of action.

Key Injury Report for St. Louis:

  • Ixan Henderson (Day-To-Day)
  • Hunter Dobbins (15-Day IL)
  • Lars Nootbar (60-Day IL)
  • Victor Santos (60-Day IL)
  • Zack Thompson (60-Day IL)

Tampa Bay vs St. Louis Pick

  • Tampa Bay vs St. Louis Spread Pick

Both teams end up with below-average pitchers for this matchup, as each had an ERA above 4 last season. Look for Saint Louis, however, to do the work as they were the better team in game one of the year. Expect Saint Louis to thrive on the offensive side again in Game 2 in front of their home fans on Saturday. Take the Cardinals to do enough scoring to get their second victory of the season Saturday against Tampa Bay.

  • Tampa Bay vs St. Louis Over/Under Pick

Both offenses exploded in game one of the season, and they will again on Saturday. Each team sends out a pitcher who had a huge ERA a year ago, and the offenses will continue to thrive. Look for runs to come in bunches on Saturday as each team again runs it up in this mashup. Take the over on Saturday as the Tampa Bay Rays again visit the Saint Louis Cardinals.

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