Washington Nationals vs Chicago Cubs Picks and Prediction for Sunday, September 7, 2025
On Sunday, the Washington Nationals (56-84, 5th NL East) play the final game of a three-game series on the road at Wrigley Field against the Chicago Cubs (81-60, 2nd NL Central). Washington lost to Chicago 11-5 on Friday in the first game of their series, which snapped a three-game winning streak for the Nationals. Washington has lost nine of the last 12 and is well off the pace for playoff contention. Chicago has won five of the last seven, and the Cubs are within 5.5 games of first-place Milwaukee in the National League Central. Chicago currently holds the first of three NL wild-card spots. Washington will play without five pitchers as well as position players Keibert Ruiz and Drew Millas. Chicago will play without six pitchers and catcher Miguel Amaya. Make sure to read this in-depth Washington Nationals vs Chicago Cubs prediction. From first pitch to final inning—our MLB picks for Washington Nationals vs. Chicago Cubs prediction keep you covered.
This article was written before these two played on Saturday.
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Washington is playing poorly both at the plate and on the mound
The Washington Nationals are 20th in batting average at .243, 23rd in on-base percentage at .308, and 25th in both runs scored with 593 and slugging percentage at .386. James Wood leads Washington in home runs with 27 and in RBI with 87. CJ Abrams is second in home runs with 17, and Luis Garcia Jr is second in RBI with 60. Washington has four players with 45 or more RBI. The Nationals have hit 230 doubles, 24 triples, and 131 home runs for 385 extra base hits in 140 games.
On the mound, Washington is 20th in Quality Starts with 43 and 29th in each of the following: WHIP at 1.43, ERA at 5.33, and batting average against at .267. Jake Irvin leads in wins with 8, while MacKenzie Gore has a team-best 173 strikeouts and leads in ERA for starters with 4.15. On Sunday, the Nationals will hand the ball to Andrew Alvarez. This season, the left-hander is 1-0 with a 0.00 ERA, 0.60 WHIP, and 4 strikeouts.
Chicago is well above average at the plate and above average on the mound
The Chicago Cubs are 7th in both runs scored with 699 and slugging percentage at .429, while 10th in on-base percentage at .320, and 15th in batting average at .249. Pete Crow-Armstrong leads Chicago in home runs with 28, and Seiya Suzuki is a close second with 27. Suzuki leads the Cubs in RBI with 89, and Crow-Armstrong is second with 85. Chicago has five players with 70 or more RBI. The Cubs have hit 234 doubles, 25 triples, and 193 home runs for 452 extra base hits in 141 games
On the mound, Chicago is 2nd in WHIP with 1.20, 10th in Quality Starts with 54, 11th in ERA with 3.88, and 13th in batting average against at .242. Matthew Boyd leads Chicago in wins with 12, strikeouts with 142, and ERA for starters with 2.94. On Sunday, Chicago will hand the ball to Colin Rea. The right-hander is 10-6 with a 4.30 ERA, 1.34 WHIP, and 98 strikeouts.
Washington Nationals vs. Chicago Cubs Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Washington Nationals vs. Chicago Cubs
- Washington Nationals +1.5 (4 units)
Washington is only 67-73 against the runline, but Chicago is even lower at 64-77. Washington has received solid production at the plate from James Wood, CJ Abrams, and Luis Garcia Jr. Those three, among others, will produce enough against a struggling Chicago starting pitcher to keep the Nationals within one run to cover the runline. In just one appearance for Washington this season, Andrew Alvarez allowed one hit and no runs in five innings when Washington beat Miami 2-0 on September 1st. Chicago starter Colin Rea has been hit hard in both of his last two outings, allowing 13 hits and nine runs in 8.2 innings. Chicago has won 9 of its last 12 games overall and 11 of the last 13 games against Washington, but will have problems covering the runline on Sunday.
Over/Under Pick for Washington Nationals vs. Chicago Cubs
- Under ( units)
The total has finished under in five of the last seven games played head-to-head between Washington and Chicago. The total has finished under in five of Chicago's last seven games played in September. As mentioned previously, Washington starting pitcher Andrew Alvarez has a 0.00 ERA through one start. Washington is 25th and runs scored and slugging percentage.
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