Washington Nationals vs. Chicago Cubs Picks and Prediction, Saturday, September 6, 2025
Washington (56-83) will be trying to pick up their second consecutive series win when they visit Wrigley Field to face Chicago (80-60) in the second game of their three-game weekend series at 2:20 PM. ET. Read on to find out which team picks up the win in this Nationals vs. Cubs prediction and get more quality MLB Betting Picks.
Brad Lord, 4-8, 4.34 ERA, will get the start for the Nationals. The Cubs will counter with Matthew Boyd, 12-7, 2.94 ERA.
Chicago is 8-2 in its last 10 games against Washington.
**This preview was written before Friday’s game was played.**
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Washington Trying To End Road Slump
The Nationals followed up their eight-game losing streak with three straight wins. They have lost five of their last six road games and will try to turn things around with a win over the Cubs.
Washington averages 4.23 runs per game, which is 22nd in the league. Their .243 batting average is 20th in the league. Their .308 on base percentage is 23rd, while their .386 slugging percentage is 25th.
CJ Adrams leads Washington with a .265 batting average, while James Wood leads the team with 27 home runs and 86 RBI.
Washington is giving up 5.45 runs per game, which is 29th in the league. Opponents have a .267 batting average against the Nationals, which is 29th in the league. Their 5.28 ERA is also 29th, as is their 1.43 WHIP.
In his last start, Lord gave up five hits and seven runs in three innings, leading to a 7-4 loss to Tampa Bay.
Chicago Going For Third Consecutive Series Win
The Cubs bounced back from their series loss to San Francisco with series wins over Colorado and Atlanta. They are on top of the NL wildcard standings, with a one-game lead over San Diego, and will try to increase their lead with a win on Saturday.
Chicago averages 4.91 runs per game, which is sixth in the league. Their .249 batting average is 15th in the league. Their .319 on base percentage is 12th, while their .427 slugging percentage is seventh.
Nico Hoerner leads the Cubs with a .288 batting average. Pete Crow-Armstrong leads the team with 28 home runs, while Seiya Suzuki leads the team with 89 RBI.
Chicago is giving up 4.09 runs per game, which is seventh in the league. Opponents have a .243 batting average against the Cubs, which is 13th in the league. Their 3.88 ERA is 10th, while their 1.21 WHIP is third.
In his last start, Boyd gave up six hits and four runs in six innings, leading to a 6-5 loss to Colorado. He gave up four hits and two runs in 7.1 innings when he faced them in July.
Nationals vs. Cubs Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Nats vs. Cubs
- Chicago Cubs -1.5 (4 Units)
The Cubs have won five of their last seven home games, while the Nationals have lost five of their last six road games. Chicago has the edge here because they’ve had a lot of success batting against right-handers, and they’re going up against Lord, who has struggled on the mound, giving up 18 runs in his last three starts. He gave up nine runs in his last three road starts and will have a hard time slowing down the Cubs.
Washington won’t be as successful offensively because they’ve struggled against left-handers, and they’re going up against Boyd, who has been dominant at home and is 10-0 in 12 home starts. He didn't give up a run in three of his last four home starts, so expect him to keep Washington’s offense in check. Take Chicago on the run line.
Over/Under Pick for Nats vs. Cubs
- Under (4 Units)
The Nationals played under the total in two of their last three games, while the Cubs played under the total in their last two games. Washington averages 4.23 runs per game and 4.49 runs per game on the road. They’re batting .228 against left-handers, and they’re facing a starter who gave up four runs in his last four home starts. The Cubs average 4.91 runs per game and 4.70 runs per game at home. They’re batting .250 against right-handers, and they’re facing a starter who gave up nine runs in his last three road starts. Don’t expect these teams to score enough runs to push the score over the total. The Cubs and Nationals played under the total in five of their last six meetings.
The Chicago Cubs will be going for their second consecutive win over the Washington Nationals when they play the second game of their three-game series on Saturday afternoon. Which one of these teams will get the win? Continue reading this Nationals vs. Cubs prediction to find out.
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