Washington Nationals vs Chicago White Sox Picks and Predictions for Saturday April 25 2026
Use Code WWWC The Washington Nationals will be back on the road Saturday for a game inside right field at 4:10 PM in Chicago, IL, against the Chicago White Sox, and we have you ready to roll with our Washington vs Chicago prediction. The Washington Nationals are struggling this season with 11 wins and 15 losses overall, having dropped 3 of the last 4, including 2 in a row following their loss to the Atlanta Braves. The Chicago White Sox are one of the worst teams in baseball, coming into this matchup with 10 wins and 15 losses, despite winning 3 of the last 4 overall. Read more about this Washington vs Chicago prediction! Struggling with handicapping? Try our MLB Predictions!
Nationals hunt a needed win
The Washington Nationals offense has been solid this season, as they have a .252 batting average and have scored 144 runs on 229 hits. Washington has a .331 OBP and a .410 team slugging percentage. Washington's pitching has been the team's biggest issue, with a 5.71 ERA this year. Cade Cavalli got the start for Washington in their last outing, giving up 2 runs on 7 hits across 5 innings of work, resulting in a no-decision. Cionel Perez came on in relief to give up 3 runs on 1 hit after recording just 1 out, resulting in the loss. James Wood and CJ Abrams led the way for the Washington offense in their last outing, driving in 1 run each.
Daylen Lile leads the Washington offense this season with a .295 batting average. Brady House has a .239 batting average, and CJ Abrams has chipped in heavily with a .292 batting average, along with a team-leading .413 OBP. James Wood has a .255 batting average and leads Washington with 10 home runs and 21 RBI's.
Key Injury Report for Washington:
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- Joan Adaon (Out)
- Cole Henry (15-Day IL)
- Josiah Gray (60-Day IL)
- Ken Waldichuk (60-Day IL)
- Trevor Williams (60-Day IL)
White Sox look to keep it going
Offensively, Chicago has been a bottom-feeder in the league with a .224 batting average. The White Sox have scored 104 runs on 186 hits. Chicago has a .316 OBP and a .386 team slugging percentage. Chicago's pitching has been just as bad, with a 4.96 team ERA, but it has allowed just 10 runs over its last 3 wins. Davis Martin got the start for Chicago in their last outing, giving up 1 run on 6 hits across 6.1 innings of work. Grant Taylor came on to record 5 outs, giving up no runs on 2 hits, leading to the victory. Andrew Benintendi led the way for the Chicago offense in their last outing with 2 hits in 5 at-bats to drive in 3 runs.
Chase Meidroth leads the Chicago offense this season with a .264 batting average. Miguel Vargas has struggled this season with a .194 batting average, and Andrew Benintendi has a .216 batting average. Munetaka Murakami has compiled a .253 batting average and leads Chicago with 10 home runs and nineteen RBI's.
Key Injury Report for Chicago:
- Austin Hays (10-Day IL)
- Chris Murphy (15-Day IL)
- Jonathan Cannon (15-Day IL)
- Kyle Teel (10-Day IL)
- Prelander Berroa (60-Day IL)
Washington vs Chicago Pick
- Washington vs Chicago Spread Pick
Neither team has been phenomenal this season, as each is well below .500. Despite the struggles coming into this matchup, Chicago will have the edge. The White Sox will be in front of their home fans for this matchup and will have the better pitcher on the mound. Look for Chicago to back their pitcher on Saturday as they continue to play well. Chicago will do the job on both sides of the dish to get a victory Saturday afternoon in Game 2 of this 3-game set.
- Washington vs Chicago Over/Under Pick
Both teams have mediocre offenses coming into this game, but each has seen high totals over the last few outings. Look for that to continue as both pitchers have had some troubles this season. Look for runs to come in bunches as both teams find their offenses early on Saturday. Take the over on Saturday afternoon in Chicago as the Washington Nationals visit the Chicago White Sox.
This prediction was written before the completion of game play on Friday.
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