Washington Nationals vs. New York Mets Picks and Prediction for Sunday, September 21, 2025

By: David Delano Published 09/21/2025, 12:27 AM ET
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The New York Mets (80-75) and Washington Nationals (63-92) meet Sunday afternoon at Citi Field to wrap up their three-game set. Washington surprised the Mets with a 5-3 extra-inning victory on Saturday, following New York's 12-6 victory on Friday.

With just over a week left in the regular season, the Mets enter this matchup clinging to a one-game lead over Cincinnati in the Wild Card race, making this game extremely important for them.

Nationals snapped their losing streak

The Washington Nationals have been stuck near the bottom of the National League standings all season, but Saturday’s win ensured they will not reach the dreaded 100-loss mark. They enter this matchup at 63-92, still trying to salvage something positive in the final stretch.

Washington’s offensive production has been a problem recently, averaging just 2.9 runs over its last 10 games while hitting .203 as a team. If the Nationals want to compete on Sunday, the bats will need to step up, as on the will be Jake Irvin, who has experienced an up-and-down year. Irvin sits at 8-13 with a 5.76 ERA and 1.43 WHIP across 29 starts, and Washington has dropped his last six outings.

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Mets holding on to wild card spot

The Mets are fighting for their postseason lives, entering Sunday’s finale with an 80-75 record and sitting one game clear of the Reds for the final Wild Card spot. Citi Field has been their haven this year, where they’ve gone 49-31. The offense has sparked their recent surge, scoring five or more runs in four of their last six contests, led by Francisco Lindor, Pete Alonso, and Brandon Nimmo. That trio continues to set the tone for an offense averaging 5.1 runs and 1.6 homers per game over the last 10 outings.

Sean Manaea gets the call for New York. While his overall numbers (2-3, 5.40 ERA, 1.20 WHIP) leave plenty to be desired, he has been more reliable at Citi Field. At home, Manaea owns a 2-0 record with a 4.30 ERA. Against Washington earlier this season, however, Manaea struggled, allowing four runs in just 4.2 innings. Washington Nationals vs New York Mets prediction

Nationals vs. Mets Pick

Runline pick for Nationals vs. Mets

  • Mets -1.5 (4 units)

With so much more to play for, the Mets are the clear side against the runline Washington is closing out another lost season while the Mets are locked into a tight playoff chase. Irvin’s recent struggles, which include six straight losses in his starts and a 5.76 ERA overall, make the Nationals unplayable, even at this price.

The Mets’ offense is producing over five runs per game recently, while the Nationals’ lineup is hitting under .210 with minimal power.

New York has covered the run line in each of their last four victories, and with the edge in urgency, they are the play.

Total pick for Nationals vs. Mets

  • Over 8.5 (4 units)

Jake Irvin has allowed at least four runs in three of his last five outings, while Sean Manaea has been inconsistent and struggled against Washington earlier this season. The Mets’ bats have scored five or more runs in four of their last six games, and even though the Nationals have been quiet lately, they showed Friday that they’re capable of erupting against mediocre pitching. With both bullpens seeing plenty of action this weekend, expect enough offensive production on both sides to push this game over.

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