Cleveland Cavaliers vs Indiana Pacers Picks, Prediction, Odds, and Line Movement for Tuesday January 6 2026
This Eastern Conference matchup carries plenty of betting intrigue, and Cavaliers vs Pacers picks deserve a close look as Cleveland and Indiana meet again with both lineups dealing with key absences. With recent head-to-head results and injury news shaping the market, this game stands out for bettors digging into tonight’s college basketball picks-style handicap in a pro setting.
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Quick Picks and Prediction
- Spread Pick: Cleveland Cavaliers -5.5
- Total Pick: Under 236.5
- Projected Final Score: Cavaliers 116, Pacers 108
Odds and Line Movement
Opening Odds
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Tony Karpinski | +2,976.00 |
| 2 |  Joe Duffy | +2,595.00 |
| 3 |  The Insiders Room | +2,320.00 |
| 4 |  Mark Ruelle | +1,627.00 |
| 5 |  Jackie Mack | +1,451.00 |
| Market | Cleveland | Indiana |
|---|---|---|
| Spread | -7 (-110) | +7 (-110) |
| Total | Over 235.5 (-110) | Under 235.5 (-110) |
Current Odds
| Market | Cleveland | Indiana |
|---|---|---|
| Spread | -5.5 (-110) | +5.5 (-110) |
| Total | Over 236.5 (-112) | Under 236.5 (-108) |
Line Movement - Spread
| Date | Time | Cleveland | Indiana |
|---|---|---|---|
| 01/05 | 08:38:38 PM | -7 (-110) | +7 (-110) |
| 01/05 | 08:45:57 PM | -6 (-110) | +6 (-110) |
| 01/05 | 08:49:45 PM | -6 (-108) | +6 (-112) |
| 01/05 | 09:15:14 PM | -5 (-110) | +5 (-110) |
| 01/05 | 09:23:53 PM | -5.5 (-108) | +5.5 (-112) |
| 01/05 | 10:35:52 PM | -5.5 (-106) | +5.5 (-114) |
| 01/06 | 11:38:42 PM | -5.5 (-110) | +5.5 (-110) |
Line Movement - Total
| Date | Time | Over | Under |
|---|---|---|---|
| 01/05 | 08:38:39 PM | 235.5 (-110) | 235.5 (-110) |
| 01/05 | 09:58:09 PM | 234.5 (-110) | 234.5 (-110) |
| 01/05 | 10:37:19 PM | 234.5 (-110) | 234.5 (-110) |
| 01/05 | 10:40:50 PM | 234.5 (-112) | 234.5 (-108) |
| 01/06 | 05:48:51 AM | 235.5 (-112) | 235.5 (-108) |
| 01/06 | 06:56:05 AM | 236.5 (-112) | 236.5 (-108) |
Key Matchups and Handicap
Cleveland has quietly taken control of this season series, winning both previous meetings by double digits, including a 135-119 road win in Indiana. That result matters because it shows Cleveland’s ability to score efficiently in this building, even before factoring in the Pacers’ recent slide.
Indiana enters this matchup in brutal form, sitting 0-12 straight-up over its last 12 games and failing to cover the spread in nine of those contests. While five of the Pacers’ last six games have gone over the total, those results came with a healthier rotation than what they will bring into this game.
The injury report dramatically reshapes the handicap. Cleveland will be without Donovan Mitchell and Larry Nance Jr., two major pieces of its scoring and rotation stability. Indiana is also shorthanded, with Bennedict Mathurin and Isaiah Jackson expected to miss this game, removing nearly 18 points per game from an offense already near the bottom of the league.
With both teams missing key scorers, efficiency becomes harder to find. Cleveland has far less experience playing without Mitchell, while Indiana simply lacks the offensive depth to replace Mathurin’s production.
Betting Trends - CLE vs IND
- Cleveland has won the first two meetings this season by double digits.
- Indiana is 0-12 straight-up over its last 12 games.
- Five of the Pacers’ last six games have gone over the total.
Key Injuries and Notes - CLE vs IND
- Cavaliers: Donovan Mitchell and Larry Nance Jr. are out.
- Cavaliers: Dean Wade and Jarrett Allen are questionable.
- Pacers: Bennedict Mathurin and Isaiah Jackson are expected to be out.
ATS and Total Picks
- ATS Pick: Cleveland Cavaliers -5.5
- Total Pick: Under 236.5
Final Score Prediction
- Cavaliers 116, Pacers 108
How to Bet on Cleveland vs Indiana
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