Cleveland Cavaliers vs New York Knicks Picks and Prediction for Wednesday November 11, 2026

The Cleveland Cavaliers will be on the road Wednesday night for an Eastern Conference matchup against the New York Knicks inside Madison Square Garden in New York. The game is scheduled to begin at 7 PM ET with coverage on ESPN. The Cleveland Cavaliers come into Wednesday night one game below .500 through 11 games played, having dropped four of the last five, including two in a row, after a 12-point road loss to Charlotte. The New York Knicks are 5-4 coming into this game but have won four of the last five, including three in a row, after a 12-point victory against this Cleveland team last time out.The New York Knicks come into Wednesday night as a 3.5 home favorite and a -177 on the money line. Cleveland is a +148, and the total is 220.5. Stay in the action with our NBA Picks.

Cleveland tries to end their skid

The Cleveland Cavaliers are averaging 117 points on 46% shooting from the floor this season. Defensively, Cleveland has had its issues, giving up 115 points per game this year, and they've allowed an average of 118.5 points per game across their last four losses. Donovan Mitchell is leading the Cleveland offense this season, averaging 24 points per game. Evan Mobley is second on the roster, averaging 18.4 points along with a team-leading 8.1 rebounds. James Harden is averaging 15.7 points, and he leads the team, dishing out 5.8 assists. Jarrett Allen is averaging 13.3 points, and Meleek Thomas is averaging 12.3 points per game. Peyton Watson is the sixth player on the Cavaliers roster in double digits, averaging 11.3 points per game.

Offensively, Cleveland scored the ball well in its last outing, pouring in 112 points on 51% shooting and 40% from beyond the arc. Defensively, Cleveland was terrible, giving up 124 points, including 69 in the first half, as Charlotte shot 47% from the floor and 50% from the outside. Cleveland lost the rebounding battle by 17 and turned the ball over 14 times in the game. Meleek Thomas led Cleveland with 18 points on 12 shots.

Key Injury Report for Cleveland:

• Sam Merrill (GTD) - Elbow
• Jaylon Tyson (GTD) - Ankle

New York goes for 4 in a row

The New York Knicks offense is averaging 109.9 points on 43% shooting. Defensively, New York is allowing 104.2 points per game this year, and they've given up an average of 97.3 points per game during their current three-game winning streak. Jalen Brunson is leading New York this season, averaging 26.2 points and 5.6 assists per game. Karl-Anthony Towns is second on the roster, averaging 20.9 points, and he leads the team, pulling in 13.6 rebounds per game. OG Anunoby is the third player on the roster in double digits, averaging 16.4 points in 33 minutes per game.

Offensively, New York exploded Tuesday night, pouring in 117 points on 45% shooting and 39% beyond the arc. Defensively, New York was dominant, giving up 85 points on 38% shooting. The Knicks won the rebounding battle by 27 and forced 14 turnovers in the win. Jalen Brunson led New York with 23 points on 18 shots.

Key Injury Report for New York :

• Josh Hart (GTD) - Ankle

Cleveland Cavaliers vs New York Knicks Picks and Prediction

Pick: New York Knicks -3.5

New York has already shown it can handle Cleveland this season and should have the advantage again Wednesday night. Jalen Brunson gives the Knicks a reliable offensive weapon capable of controlling the game, while Karl-Anthony Towns provides another scoring option who can challenge Cleveland inside and along the perimeter. The Cavaliers have enough talent to make adjustments after their recent loss, but New York's physicality and ability to control the glass could make things difficult. New York has a chance to control the glass after outrebounding its last opponent by 27, while Cleveland was outrebounded by 17 against Charlotte. That could give the Knicks extra possessions and help them cover the 3.5-point spread. Take New York to pick up another victory against the Cavaliers.

Secondary: Under 220.5

Cleveland struggled to generate consistent offense in the previous meeting, and New York should look to establish a similar defensive approach Wednesday night. The Knicks have enough size to challenge shots around the basket and force Cleveland into difficult possessions. Donovan Mitchell will get his opportunities offensively, but the Cavaliers could have trouble finding production from their supporting cast if New York controls the tempo. Cleveland should also come into this matchup with a stronger defensive effort after losing at home. Expect both teams to make adjustments and play a physical game that finishes below the total.

Final Picks: New York Knicks -3.5 and Under 220.5