Cleveland Cavaliers vs Philadelphia 76ers Picks, Prediction, Odds, and Line Movement for Friday, January 16, 2026
Use Code WWWC It’s another key Eastern Conference matchup on Friday, Jan. 16. Read our Cleveland Cavaliers vs Philadelphia 76ers prediction along with along with our other NBA Picks. The Cavaliers are 23-19 and they are in seventh place in the East. The 76ers are 22-17 and they sit in fifth place in the league. Both teams are finding their footing in the middle of the East playoff race and wins like this are big when the season comes to a close. These two teams will meet with tip-off set for 7 P.M. EST.
Cleveland notch road win over Philadelphia on Wednesday
Cleveland is 23-19 overall this season. The Cavaliers are in seventh place in the East as they are seven games back of Detroit for the top spot. Cleveland is one game back of Orlando to jump out of the play-in round. The Cavaliers are 9-9 when they have played on the road. Cleveland has won six of their last nine games coming into this matchup.
In their last game, the Cavaliers defeated Philadelphia 133-107 away from home on Wednesday, Jan. 14. It was a pretty dominate win for Cleveland, who grabbed the lead in the first quarter and never looked back. The Cavaliers shot 53% from the field and 43% from behind the arc. Donovan Mitchell led the team with 35 points on 11-for-22 shooting. But, guard Darius Garland did leave the game early due to a foot injury and his status is in question for Friday’s game.
Donovan Mitchell leads the team with 29.7 points per game. Evan Mobley is grabbing 8.7 rebounds, while Darius Garland is passing for 6.9 assists per game.
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Cleveland is the eighth ranked offensive efficient team and the 15th ranked defensive efficient team. The Cavaliers are also ranked 15th in rebounding.
The Cavaliers are averaging 120.1 points per game, which ranks fourth-best. They are shooting 47.2% from the field, which ranks 12th overall. Cleveland is hitting 35.7% from behind the 3-point line, placing them 14th overall.
On defense, the Cavaliers are allowing 117.5 points per game, which ranks 21st. They are allowing 46.6% from the field, placing them 12th overall. Cleveland is the worst 3-point defensive team, allowing 38.3% from behind the arc.
Cleveland is 14-28 against the spread this season, which is the worst record in the league. The Cavaliers are 8-20 against the spread when playing versus Eastern Conference teams. The Cavaliers are 7-15 against the spread after a win. The under is 22-20 when the Cavaliers have played. The under is 18-11 when Cleveland has had one-day of rest. The under is 13-9 after a Cleveland win.
Key injuries
- Sam Merrill (hand), questionable
- Darius Garland (foot), questionable
- Dean Wade (knee), questionable
- Max Strus (foot), out
76ers struggle in loss to Cleveland
Philadelphia is 22-17 overall this season. The 76ers are in fifth place in the East. They are one game ahead of the play-in round, while they sit 6.5 games back of No. 1 Detroit. The 76ers are 10-10 when they have played at home. The 76ers have also won six of their last nine games.
In their last game, the 76ers lost 133-107 to Cleveland at home on Wednesday, Jan. 14. The 76ers barely competed in the game, as Cleveland led by as much as 30 points. Philadelphia shot 40% from the field and 28% from behind the arc. Joel Embiid led the team with 20 points on 7-for-14 shooting.
Tyrese Maxey leads the team with 30.5 points and 6.6 assists per game. Andre Drummond is the top rebounder with 8.8 boards per game.
Philadelphia is the 16th ranked offensive and ninth ranked defensive efficient team in the league. The 76ers are also the 18th ranked rebounding roster.
Philadelphia is averaging 116.9 points per game, which ranks 13th. They are the fifth-worst shooting team, making 45.4% from the field. The 76ers are making 35.6% from behind the 3-point line, which ranks 15th.
Philadelphia’s defense is allowing 115.6 points per game, which ranks 14th. They are the 11th ranked defensive team allowing 46.4% from the field. The 76ers are the third-best 3-point defensive team surrendering 33.9% from behind the arc.
The 76ers are 21-18 against the spread this season. Philadelphia is 12-8 against the spread when they have had one day of rest. The 76ers are 17-14 against the spread versus the East. The over is 21-18 when Philadelphia has played. The total is 8-8 after a loss. The under is 5-2 when Philadelphia has been a home underdog.
Key injuries
- Dominick Barlow (back), questionable
- Cleveland Cavaliers vs Philadelphia 76ers Picks
Cavaliers vs 76ers Spread Pick
- Philadelphia 76ers -2 (5 units)
The Cavaliers may be without Darius Garland in this game, after he left in the middle of Wednesday’s game. Cleveland dominated Philadelphia two days ago and without Garland’s scoring presence, the Cavaliers become one dimensional with Donovan Mitchell as the team’s leading guard. Philadelphia should find a way to defend home court and win a big game. The 76ers did not have Tyrese Maxey at his best against Cleveland on Wednesday. Expect a big comeback from him leading the team to a home win. The 76ers are 12-8 against the spread with one day of rest. The Cavaliers are 7-15 against the spread after a win.
Take Philadelphia to cover. Cavaliers vs 76ers Over/Under Pick
- Under 234.5 (5 units)
The 76ers will try to keep the game at a crawl on Friday night. They are ranked 18th in pace, and with the two team’s familiarity from playing on Wednesday, I expect the defensive intensity to raise. The absence of key players will also stunt any sort of high scoring game. The under is 13-9 after a Cleveland win.
Take the under on Friday.
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