Detroit Pistons at Milwaukee Bucks, Picks, Odds, Preview, and Prediction, Saturday, November 22, 2025
It’s an Eastern Conference battle in a strong matchup on Saturday, Nov. 22. Read our Detroit Pistons vs Milwaukee Bucks prediction along with our other NBA Picks. The Pistons are 13-2 and have the best record in the Eastern Conference by multiple games. Detroit is riding an 11-game win streak as they have dominated their opposition. The Bucks are 8-8, and they have lost five of their last seven games. Star player Giannis Antetokounmpo is out and the Bucks will look to other scoring options to step up. These two teams will meet with tip-off set for 8 P.M. EST.
Sign Up for Winners and Whiners News Alerts, Get Free Picks and Discounts
Subscribe Now
Detroit has fantastic start to new season, leads East
Detroit has been dominant through the first portion of the season. The Pistons are 13-2 and they lead the Eastern Conference by three games. Detroit is 5-1 when they have played on the road. After starting 2-2, the Pistons are riding an 11-game winning streak. This will be their first meeting of the season against the Bucks.
In their last game, the Pistons defeated Atlanta on the road 120-112 on Tuesday, Nov. 18. It was a fairly straightforward win for the Pistons, who never trailed in the game. They shot 54% from the field and 32% from behind the 3-point line. They forced 19 turnovers, which led to 30 points. Cade Cunningham led the team with 25 points while Jalen Duren added 24 points in the win.
Cunningham leads the team with 27.2 points and 9.9 assists per game. Jalen Duren is the top rebounder with 11.9 boards per game.
Detroit ranks 12th in offensive efficiency. They are the second-best defensive efficient team in the sport, too. The Pistons also rank eighth in rebounding
Detroit is averaging 118.9 points per game, which ranks 14th. They are the 10th-ranked shooting team, making 48.1% from the field. The Pistons are hitting 34.6% from behind the arc, which ranks 21st.
On defense, the Pistons are allowing 112.1 points per game, placing them third best. They are the fourth-ranked defensive team, allowing 43.9% from the field. Opponents are hitting 35.3% from behind the 3-point line, placing Detroit ninth defensively.
Detroit is 11-4 against the spread this season. The Pistons have covered in four straight games. They are 5-2 against the spread when they have played on the road. Detroit is 8-3 against the spread when they have been favored. They are 3-1 against the spread as an underdog. The over is 8-7 when the Pistons have played this season. The under is 4-3 when they have played on the road.
Key injuries for Pistons
- F Tobias Harris (ankle), questionable
- F Caris LeVert (ankle), questionable
Bucks struggles continue, especially in Antetokounmpo’s absence
Milwaukee is 8-8 overall this season. The Bucks are in 11th place in the East. They are one of five teams in the conference that are at .500 or worse. They are 5-4 when playing at home. Milwaukee has lost three straight games and they have also lost five of their last seven games. The Bucks have lost back-to-back games since Giannis Antetokounmpo went down injured in a game against the Cavaliers earlier this week.
In their last game, the Bucks lost 123-114 in overtime to the 76ers on Thursday, Nov. 20. Myles Turner hit a 3-pointer in the closing seconds to give the Bucks the lead, but Philadelphia’s Tyrese Maxey hit a pair of free throws to tie the game and send it to overtime, where the 76ers dominated. Milwaukee’s largest lead was just six points in the loss as they shot 49% from the field and 39% from behind the arc. Ryan Rollins led the team with 32 points on 13-for-26 shooting.
Without Antetokounmpo, the Bucks are led in scoring by Ryan Rollins with 18.3 points and a team-high 5.9 assists per game. Myles Turner is the team’s leading rebounder with 6.5 boards per game.
Milwaukee ranks 14th in offensive efficiency. They are the 19th-ranked defensively efficient team in the league, too. The Bucks are placed 24th in rebounding.
The Bucks are averaging 117.4 points per game, which ranks 18th. They are the fifth-ranked shooting team, making 49.5% from the field. Milwaukee is placed second in 3-point shooting as they are hitting 41.3% from behind the arc.
On defense, the Bucks are allowing 119 points per game, which ranks 20th. They are the 18th-ranked defensive team, giving up 47% from the field. The Bucks are the eighth-ranked 3-point defensive team, forcing opponents to shoot 34.7%.
The Bucks are 7-9 against the spread this season. They haven’t covered in three straight games. They have also failed to cover in nine of their last 11 games. Milwaukee is 5-4 against the spread at home this season. They are 4-4 against the spread as an underdog, failing to cover in four straight occurrences. The over is 9-7 when Milwaukee has played. The over is 7-2 when the Bucks have played at home.
Key injuries
- F Giannis Antetokounmpo (thigh), out
- F Taurean Prince (neck), out
- G Kevin Porter (knee), out
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +1,570.00 |
| 2 |  Dan Kaiser | +1,223.00 |
| 3 |  Ross Benjamin | +1,000.00 |
| 4 |  Earle Sports Bets | +916.00 |
| 5 |  David Hess | +706.00 |
Detroit Pistons vs Milwaukee Bucks Picks
Pistons vs Bucks Spread Pick and Prediction
- Take the Pistons to cover (5 units)
It’s been a fantastic start to the season for the Pistons. They have been peeling off win-after-win to begin this season and it is not slowing down, especially on Saturday against the Bucks. Detroit ranks second in defensive efficiency. The offense is also above average, ranking 12th in offense efficiency, headlined by Cade Cunningham and the rise of Jalen Duren. The team can move the ball quickly and the team’s balance is dominating the opposition. The Pistons have covered in four straight games. They are 5-2 against the spread when they have played on the road. Detroit is 8-3 against the spread when they have been favored. Without Antetokounmpo, the Bucks are always going to struggle. Against Detroit, they are going to play poorly once again. The Bucks have failed to cover in four straight games as an underdog. They have also failed to cover in nine of their last 11 games. The defense is an issue, while rebounding has been a problem as well. They rank in the bottom half of the NBA in both categories.
Take the Pistons to cover
Pistons vs Bucks Over/Under Pick
- Take the under (5 units)
The Pistons have prided themselves on defense through the first month of the season. Jalen Duren has been a serious lane stuffer and has been great at rebounding. The Pistons are the second-best defensive efficient team in the sport, only behind Oklahoma City. The Bucks are also the eighth-ranked 3-point defensive team in the sport. Milwaukee is also one of the slowest teams in the sport as they rank fourth slowest in pace. Detroit does rank 10th in pace, but their defensive prowess offsets the pace by a considerable margin. The under is 4-3 when the Pistons have played on the road.
Take the under on Saturday.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $150
