Los Angeles Lakers vs. Minnesota Timberwolves Picks and Prediction for Wednesday, October 29, 2025
Use Code WWWC Los Angeles Lakers (2-2) vs. Minnesota Timberwolves (2-2)
The NBA betting action continues Wednesday, October 29, 2025, with the Los Angeles Lakers taking on the Minnesota Timberwolves in the Western Conference showdown at Target Center in Minneapolis, MN, so here’s our Lakers vs. Timberwolves prediction and the latest team stats and news.
The Lakers meet the Timberwolves for the second time this season. Last Friday, the Lakers cruised past the Timberwolves 128-110, playing as 1.5-point home underdogs. The game went over the 226-point line.
Will Minnesota get revenge in front of the home fans? Read more about this Lakers vs. Timberwolves prediction, and check out all our NBA picks for Wednesday night. The tip-off at Target Center is set at 9:30 PM ET.
The Lakers are struggling with injuries
The Los Angeles Lakers fell to 2-2 SU and ATS on the season following Monday’s 122-108 home loss against the Portland Trail Blazers. The Lakers committed a staggering 25 turnovers and made just seven of their 27 attempts from beyond the arc, so a double-digit loss was inevitable.
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Purple-and-Gold were quite shorthanded last time out. Luka Doncic (finger) missed his second straight game, Gabe Vincent hit the sidelines with an ankle injury, and Jaxson Hayes didn’t play due to a patellar tendon strain. Maxi Kleber is out with an abdominal strain, while LeBron James won’t make his season debut soon because of sciatica.
Marcus Smart (quadriceps) also missed the Trail Blazers game, and he’s questionable for Wednesday’s clash against the Timberwolves. Austin Reaves dropped 41 points on Portland, a day after scoring 51 in a 127-120 road victory over the Sacramento Kings. Against the Trail Blazers, Rui Hachimura, DeAndre Ayton, and Dalton Knecht scored 16 points each.
The Timberwolves miss their best player
The Minnesota Timberwolves dropped to 2-2 SU and 0-4 ATS on the young season following Monday’s 127-114 home defeat to the Denver Nuggets. The T-Wolves blew an eight-point lead from halftime, allowing a whopping 45 points in the third quarter. Denver outrebounded Minnesota 46-33, and the Timberwolves went just 10-for-32 from downtown.
Jaden McDaniels led the way for Minnesota last Monday, notching 25 points, three rebounds, and four blocks in 35 minutes on the floor. Julius Randle had 24 points and seven boards, and Naz Reid added 18 points and seven boards off the bench.
The Timberwolves cannot count on their best player, as Anthony Edwards suffered a hamstring injury in a 114-110 home victory over the Indiana Pacers this past Sunday. He will be sidelined for a couple of weeks, at least. Mike Conley replaced Edwards in the starting lineup last Monday and posted a line of 10 points, four assists, three rebounds, a block, and a steal.
Lakers vs. Timberwolves Pick
Spread Pick for Lakers vs. Timberwolves
- Minnesota Timberwolves (4 units)
I won’t overthink this matchup. The Timberwolves are without their best player, but the Lakers have been hit by the injury bug seriously.
Hereof, I expect the Timberwolves to get revenge for last week’s loss at Los Angeles. They have enough defensive weapons to slow Austin Reaves down. The Lakers just committed 25 turnovers against the Trail Blazers, and this is another challenging matchup for Purple-and-Gold. Also, the Timberwolves’ second unit could easily make a difference.
Last Friday, the Lakers beat the Timberwolves on the back of Luka Doncic’s 49-point display. Doncic earned 19 free throws and handed out eight assists, while Austin Reaves had 25 points and 11 dishes. The Lakers allowed 15 offensive rebounds, but they outscored Minnesota 60-47 in the second half.
Over/Under Pick for Lakers vs. Timberwolves
- Under (4 units)
The Timberwolves’ defense has been underperforming thus far. Minnesota ranks 26th in the NBA in adjusted defensive efficiency (119.4 points allowed per 100 possessions), while the Lakers rank 18th in this category (116.1). Both teams are in the middle of the pack when it comes to pace.
T-Wolves will start improving sooner rather than later, and the clash against the injury-depleted Lakers is a perfect opportunity for Minnesota’s defense to prove its worth. Give me the under.
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