Memphis Grizzlies vs. Phoenix Suns Picks and Prediction for Wednesday, October 29, 2025

By: Victor King Published 10/29/2025, 10:38 AM ET
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Memphis Grizzlies (2-2) vs. Phoenix Suns (1-3) 

The 2025-26 NBA season goes on Wednesday, October 29, with the Memphis Grizzlies squaring off against the Phoenix Suns in the Western Conference clash at Mortgage Matchup Center in Phoenix, AZ, so we’ve prepared the Grizzlies vs. Suns prediction to get you covered.

Memphis and Phoenix open their three-game regular-season series. They locked horns four times in 2024-25, and the Grizzlies swept the Suns while going 2-2 against the number. Memphis aims for its sixth straight victory over Phoenix.

Now, let’s take a closer look at this Grizzlies vs. Suns prediction, one of our NBA picks for Wednesday night. The tip-off at Mortgage Matchup Center is set at 10:00 PM ET.

The Grizzlies have been inconsistent thus far                                                   

The Memphis Grizzlies (2-2; 2-2 ATS; 3-1 O/U) have alternated wins and losses so far this season. They started with a three-game homestand, sandwiching a heavy 146-114 defeat to the Miami Heat with a couple of wins over the New Orleans Pelicans, 128-122, and the Indiana Pacers, 128-103.

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Last Monday, the Grizzlies opened a two-game road trip with a 131-118 loss at the Golden State Warriors. It was a lousy defensive performance by the Grizzlies, who allowed 19 3-pointers and 36 assists. Memphis shot 45.5% from the field (12-for-39 from deep), and Ja Morant led the way with 23 points and nine assists.

The Grizzlies entered the season with slight injury problems and cannot count on Brandon Clarke, Zach Edey, Scotty Pippen Jr., and Ty Jerome. Memphis’ 3-point defense has been a serious issue thus far, as the Grizzlies allow 14.7 triples per 100 possessions (25th in the NBA) on a 41.3 percentage clip (29th).

The Suns hope to stop a three-game slide                                                

The Phoenix Suns (1-3; 1-3 ATS; 4-0 O/U) beat the Sacramento Kings 120-116 at home in their season opener. Since then, the Suns have dropped three consecutive road games against the LA Clippers 129-102, the Denver Nuggets 133-111, and the Utah Jazz 138-134 in overtime.

The Suns are coming off Monday’s tough loss against Utah. Phoenix erased an 11-point deficit in the final three minutes of the fourth quarter but couldn’t find a way to come out on top in overtime. The Suns gave up 28 offensive rebounds, which is shocking. They shot 42.5% from the field (20-for-55 from deep), and Devin Booker led the way with 34 points and 10 assists.

Booker is averaging 26.7 points and 5.7 assists, but he’s not getting a lot of help from his teammates. The Suns’ frontcourt is pretty thin, while Jalen Green (hamstring) is still waiting for his Suns debut. Dillon Brooks (19.3 PPG, 3.3 RPG) missed the Jazz game with a groin injury and is questionable for Wednesday’s clash versus Memphis.

Grizzlies vs. Suns Pick 

Spread Pick for Grizzlies vs. Suns    

  • Memphis Grizzlies (4 units) 

The Suns’ defense was awful last season, and the woes continue in 2025-26. Phoenix allows a whopping 125.3 points per 100 possessions (29th in the NBA) on 56.3% shooting from inside the arc (19th) and 37.6% from beyond the 3-point line (25th).

Hereof, I expect the Grizzlies to extend their dominance over the Suns. The Grizzlies miss a couple of important players in their frontcourt, but as I said, the Suns’ frontcourt is pretty thin. The Suns are dead last in the league in defensive rebound percentage (65.7%).

Memphis plays fast while taking good care of the ball (4th in the NBA in turnover percentage, 11.8%), and the Suns will struggle to contain the Grizzlies.

Over/Under Pick for Grizzlies vs. Suns     

  • Over (4 units) 

Given the defensive issues on both sides, I can only look at the over when it comes to the total in this game. Both teams struggle to defend the 3-point line while leaning on 3-pointers. The Grizzlies are eighth in the NBA in 3-point rate (.444), and the Suns rank fourth in this category (.491).

Moreover, the Grizzlies love to push the ball in transition. They tally 105.7 possessions per 48 minutes (4th in the league). The Suns are 18th in pace with 100.3 possessions per 48 minutes, and each of their first four games this season has gone over the total.

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