Minnesota Timberwolves vs. Los Angeles Lakers Picks and Prediction, Friday, October 24, 2025

By: David Delano Published 10/24/2025, 10:20 AM ET
Timberwolves vs. Lakers prediction
Use Code WWWC

The Los Angeles Lakers (0-1) and Minnesota Timberwolves (1-0) meet tonight in a playoff rematch.

The Timberwolves, who bounced the Lakers in five games in the first round last season, opened the year with a 118–114 win over Portland.  The Lakers, meanwhile, dropped their opener 119–109 to Golden State despite Luka Doncic putting on a show with 43 points.

Minnesota opened up a winner

Minnesota enters this season with strong championship hopes, holding +1800 odds on ESPNBet, ranking as the 8th most likely NBA team to win it all. Their season opened with a hard-fought 118-114 victory over Portland, highlighted by Anthony Edwards scoring 41 points and grabbing seven rebounds. He went 14 of 28 from the floor and had five three-pointers.

Despite the win, the Timberwolves displayed some early-season rust, committing 19 turnovers, though Edwards took over in crucial moments to secure the win. One of Minnesota’s biggest advantages this season is chemistry, as they retained seven of their top eight rotation players, including key contributors Julius Randle, Jaden McDaniels, and Rudy Gobert.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Their shooting impressed, going 15-for-30 from three-point range in the opener. While there are still growing pains to work through, Minnesota’s solid core and cohesion give them a strong foundation to build on this year.

No key injuries.

Lakers waste Luka's 43 points

The Lakers have the 5th-best championship odds on ESPN Bet at +1500. Opening night didn’t go as planned for the Lakers, but there were flashes of what this team could become once LeBron James returns. Luka Doncic was sensational, dropping 43 points with 12 rebounds and nine assists in a losing effort to the Warriors. He looked completely in control and in better shape, but he could not lead the team to victory.

Alongside Doncic, Austin Reaves was solid with 26 points and nine assists, and DeAndre Ayton showed some life with 10 points and six rebounds, but the rest of the supporting cast was quiet, as the Lakers shot just 25 percent from deep.

LeBron James (back) is out for several weeks. F Maxi Kleber (oblique) is also out.

Minnesota Timberwolves vs. Los Angeles Lakers Predictions

Spread Pick for Timberwolves vs. Lakers

  • Minnesota -2.5 (5 units)

Minnesota’s got the chemistry, confidence, and depth edge here. The Wolves have also covered in six of the last eight against L.A., and their physicality is a real problem for a Lakers team missing LeBron. Without Bron's playmaking and leadership, the Lakers lean heavily on Doncic to create every shot, and that’s a tough ask against a defense like Minnesota's. Minnesota shot the ball much better from three in their opener, and I expect them to control the pace and pull away in the fourth quarter for another solid win and cover.

Total Pick vs. T-Wolves vs. Lakers

  • Under 225.5 (5 units)

This one sets up as more grind than track meet. The under has hit in seven of the last nine head-to-head meetings, and both teams are still fine-tuning their offense. Minnesota’s defense is built to slow games down, and the Lakers’ lack of spacing without LeBron.

Expect a lot of half-court sets, and long possessions.

I love the under.

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more NBA predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.