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Minnesota Timberwolves vs San Antonio Spurs Picks, Prediction and Odds Game 2

By: Kyle Kargel Published 05/06/2026, 09:02 AM ET
Timberwolves vs Spurs prediction Game 2

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The Minnesota Timberwolves stole Game 1 in San Antonio thanks to a surprise return from their franchise star, and Wednesday night brings a Game 2 spot where the total has dropped meaningfully despite the matchup history pointing in the opposite direction. For more NBA picks and daily breakdowns, our coverage runs deep, but this Timberwolves vs Spurs Game 2 deserves a focused handicap given Anthony Edwards’ expected larger role, the wild shooting variance from Game 1 and a closing number that has the Under getting hammered hard in the public market.

Quick Picks and Prediction

  • Spread Pick: Spurs -9.5
  • Total Pick: Over 215.5
  • Projected Final Score: Spurs 115, Timberwolves 104

Odds and Line Movement

The market opened with San Antonio as a sizable home favorite at -8.5 and has since climbed to -9.5 across multiple refreshes. The total opened at 214.5 and has bounced between 214.5 and 215.5, with the Under drawing very heavy public ticket support throughout the night despite the offensive history between these two clubs.

Opening Odds

Date Time Minnesota San Antonio Total
05/05 12:17:22AM 8½-110 -8½-110 214½ (O-110 / U-110)

Current Odds

Date Time Minnesota San Antonio Total
05/05 05:58:20PM 9½-104 -9½-118 215½ (O-106 / U-114)

Line Movement - Spread

Date Time Minnesota San Antonio Public ($, #)
05/05 05:58:20PM 9½-104 -9½-118 SA 67%, SA 53%
05/05 12:48:06PM 9½-106 -9½-114 MIN 62%, MIN 75%
05/05 10:37:16AM 9½-108 -9½-112 MIN 62%, MIN 75%
05/05 12:51:59AM 9½-112 -9½-108 MIN 100%, MIN 100%
05/05 12:50:34AM 9½-110 -9½-110 MIN 100%, MIN 100%
05/05 12:32:15AM 8½-106 -8½-114 MIN 100%, MIN 100%
05/05 12:31:16AM 8½-108 -8½-112 MIN 100%, MIN 100%
05/05 12:30:49AM 8½-110 -8½-110 MIN 100%, MIN 100%
05/05 12:20:16AM 9½-114 -9½-106
05/05 12:18:46AM 9½-110 -9½-110
05/05 12:18:19AM 8½-106 -8½-114
05/05 12:17:22AM 8½-110 -8½-110

Line Movement - Total

Date Time Over Under Public ($, #)
05/05 06:27:43PM 215½-106 215½-114 UN 90%, UN 77%
05/05 06:27:22PM 215½-108 215½-112 UN 90%, UN 77%
05/05 06:00:13PM 215½-112 215½-108 UN 88%, UN 73%
05/05 12:38:40AM 215½-110 215½-110
05/05 12:18:19AM 214½-114 214½-106
05/05 12:17:22AM 214½-110 214½-110

Timberwolves vs Spurs Key Matchups and Handicap

Game 1 turned on a surprise that very few people saw coming. Anthony Edwards was originally targeting a Game 3 return when the series shifts to Minneapolis, but he made his way back early and played 25 minutes off the bench, scoring 18 points on 8-of-13 shooting. That kind of efficient return on limited minutes is the central swing factor heading into Game 2, because the Spurs are now preparing for a healthier, more comfortable Edwards on a likely larger workload after shaking the rust off in Game 1.

Despite the loss, San Antonio still showed why this matchup is dangerous defensively. Victor Wembanyama was a force at the rim with 12 blocks and 15 rebounds, even though he finished with only 11 points in 40 minutes after going 0-for-8 from three. The Timberwolves’ coaching staff almost certainly has to adjust the offensive approach in Game 2 after watching Wembanyama erase that many shots at the rim, which favors a different shot profile and likely more perimeter looks for Minnesota the second time through.

The shooting variance is the other key piece. Wembanyama, De’Aaron Fox and Dylan Harper combined to shoot just 1-for-16 from three in Game 1, which is the kind of number that almost never repeats. Even with Wembanyama anchoring the defense, regression toward the mean for that three-headed perimeter group should add real points to the San Antonio side of the ledger. Pair that with Edwards likely demanding more touches and the Timberwolves missing 9 of 21 free throws in Game 1, and the path to a higher-scoring game is clear. Minnesota also went a perfect 6-1 in the last seven meetings against San Antonio, but the recent regular-season series saw an average of 231.0 points per game, well above the current Game 2 number.

Minnesota walks into Game 2 with all the momentum after the Game 1 upset, and Edwards’ surprise return has only added to the storyline. The public reflected that early, with money and ticket counts at 100 percent on the Timberwolves spread when the line first opened, before settling back into a more split look as San Antonio drew sharper interest in the most recent windows. The Spurs now sit at 67 percent of the spread money in the most recent refresh, suggesting the home side is being backed by larger wagers as game time approaches.

San Antonio is in a classic Game 2 bounce-back spot at home after losing the opener despite Wembanyama’s historic defensive line. The total has drawn extreme public Under support, with money percentages reaching 90 percent and ticket counts in the 73 to 77 percent range. That is a tough public lean to ride against given the offensive history between these two teams and the variance baked into Game 1’s shooting numbers, which makes Over 215.5 the more interesting side of the total.

MIN and SA Key Injuries and Notes

Edwards is the central injury note coming out of Game 1, and his early return changes the calculus on both sides. He played 25 minutes off the bench and was efficient at 8-of-13, but he is presumably in line for a larger role in Game 2 after shaking off rust in his first game back. That alone should push Minnesota’s offensive ceiling higher than what the market has currently priced into the total.

San Antonio’s biggest issue is on the offensive end rather than the injury report, with Wembanyama, Fox and Harper combining for that 1-for-16 night from three. The Spurs’ defensive identity is intact with Wembanyama anchoring the rim, but they need at least a couple of those perimeter looks to fall to make Game 2 a true bounce-back spot. The combination of expected positive regression for the trio and a likely shift in Minnesota’s offensive approach away from challenging Wembanyama at the rim points to a higher-scoring night for both sides.

Timberwolves vs Spurs ATS and Total Picks

  • ATS Pick: Spurs -9.5
  • Total Pick: Over 215.5

The Spurs -9.5 pick is the bounce-back lean, leaning on a home Game 2 spot, expected positive shooting regression from Wembanyama, Fox and Harper, and a Timberwolves group that may be without the same surprise advantage that Edwards’ return provided in the opener. The Over 215.5 is the cleaner play of the two, given the 231.0 points-per-game average in the recent regular-season series, the 37 fast-break points combined in Game 1 and the variance baked into Game 1’s shooting that should push the scoring closer to the historical norm.

Final Score Prediction

  • Final Score: San Antonio 115, Minnesota 104

Wembanyama and Fox find their three-point stroke, the Spurs adjust their defensive coverages on Edwards now that Minnesota is showing him on the floor, and San Antonio takes control in the second half. Minnesota stays competitive thanks to Edwards’ scoring punch, but the home team’s offensive corrections push them past the spread. A 115-104 final clears Spurs -9.5 and lands the Over 215.5.

How to Bet Timberwolves vs Spurs

With the spread sitting at -9.5 and the juice swinging based on small line moves, locking in the best price on Spurs -9.5 is the priority, because every cent matters when you are laying double-digit-adjacent numbers. The total at 215.5 has bounced between -106 and -114 on the Over, so checking books before placing the bet can squeeze a little more value out of the play on Over 215.5.

If you are in a state without traditional online sportsbooks, social sportsbooks are a strong alternative for getting action down on this Timberwolves vs Spurs Game 2 using sweepstakes-style play. Fliff is one of the most popular options for NBA bettors, and you can boost your starting balance by using our fliff promo code before placing your action on Spurs -9.5 or Over 215.5 in San Antonio.

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