Philadelphia 76ers at Cleveland Cavaliers Picks, Odds, Preview, and Prediction, Wednesday, November 5, 2025
Use Code WWWC It’s an Eastern Conference battle on Wednesday, Nov. 5. Read our Philadelphia 76ers vs Cleveland Cavaliers prediction along with our other NBA Picks. The 76ers have had one of the best starts to the new season as they are coming off of a game on Tuesday night. The Cavaliers are 4-3 and are starting slow out of the gates as injuries have slowed their early progress. These two teams will meet with tip-off set for 7 P.M. EST.
76ers playing on heels of back-to-back
Philadelphia is 5-2 overall this season. They are 3-1 when they have played on the road. The 76ers started the season with four straight wins. They have followed it by losing two of their last three games.
In their last game, the 76ers lost 113-111 to the Bulls on the road on Tuesday, Nov. 4. Philadelphia led for a majority of the game before they collapsed in the final seconds. The Bulls went on a 9-0 run in the final 4:23 left in the game to steal the win. Chicago’s Nikola Vucevic hit a 3-pointer in the final seconds to win the game. The 76ers blew a 24-point lead as they shot 42.6% from the field and 36.7% from behind the arc. Tyrese Maxey led the team with 39 points on 14-for-26 shooting.
Maxey leads the team with 33.7 points and nine assists per game. Andre Drummond is grabbing a team-leading 6.7 rebounds per game, too.
Get Free $30 Credit for Premium Picks + Exclusive Discounts
Subscribe Now
Philadelphia is averaging 125.8 points per game, which is the most in the league. They are shooting 47.9% from the field, placing them 14th. The 76ers are the fourth-best 3-point shooting team, making 40.6% from behind the arc.
On defense, the 76ers are allowing 118.3 points per game, ranking 20th. They are the 17th-ranked defensive team, allowing 47% from the field. Philadelphia is also the best 3-point defensive team, giving up 30.9% from the field.
Philadelphia is the third-ranked offense-efficient team in the league. They also rank 14th in defensive efficiency while being the 25th-best rebounding squad.
The 76ers are 5-1-1 against the spread this season. They are 3-0-1 against the spread this year on the road. They are 3-0-1 against the spread when they have been underdogs. The over is 5-2 when the 76ers have played. The over is 3-1 when they have played away from home.
Paul George and Dominick Barlow both missed Tuesday’s game against the Bulls.
Slow start to the season for Cleveland
The Cavaliers are 4-3 overall this season. They are 2-1 when they have played at home. Cleveland won three of their first four games with a defeat to New York starting the campaign. The Cavaliers have lost two of their last three games with defeats to Boston and Toronto.
In their last game, the Cavaliers defeated Atlanta 117-109 at home on Sunday, Nov. 2. The Cavaliers controlled the lead for the majority of the game, with Atlanta’s largest lead being just four points. Cleveland shot 41.2% from the field and 35.1% from behind the arc. The Cavaliers did force 23 turnovers, which led to 33 points. Donovan Mitchell led the team with 37 points on 12-for-21 shooting.
Mitchell leads the team with 29.5 points per game. Evan Mobley has a team-high 8.9 rebounds per game, while Lonzo Ball is passing for a team-leading 5.3 assists per game.
Wednesday’s game against the 76ers could mark the season debut for point guard Darius Garland. The All-Star hasn’t played this year due to a toe injury, but could return against Philadelphia.
Cleveland is averaging 114.1 points per game, which ranks eighth-worst. They are shooting 44.5% from the field, ranking sixth-worst. They are the 16th-best 3-point shooting team.
On defense, the Cavaliers are allowing 114 points per gam,e placing them ninth. They rank 11th in opposing field goal percentage, allowing 46.5% from the field. Opponents are making 37% from behind the ar,c placing Cleveland seventh worst.
The Cavaliers rank fifth-worst in offensive efficiency. They are the seventh most defensively efficient team, too. Cleveland is also the fourth-worst rebounding team.
Cleveland is 2-5 against the spread this season. They are 1-2 against the spread when playing at home. They have been favored in every game this year. The under is 5-2 when the Cavaliers have played, too. The under is 3-0 when Cleveland has played at home.
Darius Garland, Jarrett Allen, Sam Merrill, and Max Strus are all questionable for Wednesday’s game.
Philadelphia 76ers vs Cleveland Cavaliers Picks
76ers vs Cavaliers Spread Pick
- Philadelphia 76ers +10.5 (5 units)
The 76ers have been the surprise team through the first few weeks. They have been excellent, securing five early wins with each of their losses coming by single digits. The Cavaliers have been the opposite as they have suffered losses that have not been expected, but injuries have decimated the team. Darius Garland is expected to make his season debut this game, but the 76ers' consistency on the offensive and defensive end will be hard to slow down in this game. Momentum is rolling with the road team, and they are double-digit underdogs, which is easy to side with.
Take the 76ers to cover.
76ers vs Cavaliers Over/Under Pick
- Over 233.5 (5 units)
Philadelphia and Cleveland are two of the fastest teams in the league. The 76ers are ranked ninth in pace while the Cavaliers are the fourth fastest teams. The 76ers rank third best in offensive efficiency, while Cleveland has some key pieces returning to the lineup with Darius Garland’s possible return.
Take the over on Wednesday.
Never Tried Winners and Whiners? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code DOLLAR
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
- Check out more NBA predictions
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
