Philadelphia 76ers vs Chicago Bulls Prediction and Picks - November 4, 2025

By: Dean Whitaker Published 11/04/2025, 06:32 AM ET
Nikola Vucevic looks to lead the Bulls over the Sixers
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NBA action on Tuesday evening, and we have a Philadelphia 76ers vs Chicago Bulls prediction locked and loaded for you. Philadelphia comes in off a strong 129-105 road win over Brooklyn to improve to 5-1 on the young season. The Bulls are off a 128-116 loss to the Knicks on the road and are now 5-1 on the year. These teams split the 4 meetings last year. Read on to see our 76ers vs Bulls prediction.

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A Strong Start For The Sixers

The Sixers come into Chicago riding high after a dominant 129-105 win over the Brooklyn Nets on Sunday, a game where Kelly Oubre Jr. erupted for 29 points and Tyrese Maxey added 26. Even without Joel Embiid, who sat out for knee management, Philadelphia looked sharp and in control from the opening tip. They shot over 52 percent from the field, moved the ball with purpose, and forced 19 turnovers, showing the kind of balance that has them sitting at 5-1 on the season. For a team that stumbled badly last year, this group looks energized and confident, with Maxey clearly stepping into the role of offensive leader.

What stands out about this Sixers team is their pace and spacing. Maxey has been relentless pushing the ball, and rookie VJ Edgecombe has given them another dynamic scorer who can create his own shot. Quentin Grimes has also been a valuable spark off the bench, dropping 22 points against Brooklyn while dishing out 13 assists. That kind of depth scoring is something Philadelphia has lacked in recent years, and it’s made them much harder to defend. Even when Embiid isn’t on the floor, they’ve shown they can spread defenses out and attack from multiple angles.

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Defensively, there’s still work to be done. The Sixers are giving up over 118 points per game, and while they’ve been able to outscore opponents so far, that’s not always sustainable against elite competition. Nick Nurse has emphasized ball pressure and forcing turnovers, and that strategy worked against the Nets, but Chicago presents a different challenge with their size and ball movement. If Philadelphia can keep the Bulls from getting comfortable in the half court and limit second-chance opportunities, they’ll give themselves a real shot to extend their road winning streak.

Bulls Suffer First Loss Of The Year

Chicago enters this matchup at 5-1 as well, though they’re coming off their first loss of the season, a 128-116 setback to the Knicks at Madison Square Garden. In that game, the Bulls simply couldn’t slow down New York’s perimeter shooting, giving up 20 made threes at nearly 48 percent. Josh Giddey did everything he could, recording a triple-double with 23 points, 12 assists, and 12 rebounds, while Nikola Vucevic added 17 points and 14 boards. But the defensive lapses were too much to overcome, and it snapped what had been a strong start to the year.

The Bulls’ offense has been humming, averaging over 121 points per game while shooting 50 percent from the field. Giddey has been the engine, nearly averaging a triple-double through six games, and his chemistry with Vucevic has been a big reason for their early success. Rookie Matas Buzelis has also provided a spark, showing confidence as a scorer and giving Chicago another weapon on the wing. When they’re moving the ball and knocking down shots, the Bulls can hang with anyone, and they’ve been especially tough at home, where they’re unbeaten so far this season.

Defensively, though, Chicago has shown cracks. They’ve been solid against the three-point line overall, but when teams get hot, as the Knicks did, they’ve struggled to adjust. The Bulls also have a tendency to foul too much, putting opponents on the line at a high rate. Against a Sixers team that thrives on pace and perimeter shooting, that could be a problem if they don’t tighten up. Still, with the United Center crowd behind them and Giddey orchestrating the offense, Chicago has every reason to believe they can bounce back quickly and prove that their strong start wasn’t a fluke.

Philadelphia 76ers vs Chicago Bulls Pick

76ers vs Bulls Spread Pick

  • Chicago -1.5 (2 Units)

Backing Chicago -1.5 feels like the right side because the Bulls have been excellent at home and are built to exploit Philadelphia’s defensive lapses. Josh Giddey has been orchestrating the offense at a high level, nearly averaging a triple-double, and his chemistry with Nikola Vucevic gives Chicago a reliable inside-out game that can punish the Sixers if they overcommit on the perimeter. Add in the emergence of rookie Matas Buzelis as a confident scoring option, and the Bulls have multiple ways to attack a Philly defense that has been giving up points in bunches despite its recent wins.

The other edge for Chicago is their ability to control tempo in front of the United Center crowd. The Sixers have leaned heavily on Tyrese Maxey’s pace and Kelly Oubre’s hot shooting, but if those two cool off even slightly, Philadelphia doesn’t have the same depth of scoring options. Chicago, meanwhile, has been efficient from the field and has shown they can get to the free-throw line consistently, which should help them close out a tight game. With both teams sitting at 5-1, this matchup has the feel of an early-season measuring stick, and the Bulls’ balance and home-court advantage make them the stronger play to cover the short number.

76ers vs Bulls Over/Under Pick

  • Under 239.5 (1 Unit)

The under 239.5 feels like the sharper side because while both the Sixers and Bulls have been scoring at a high clip, this matchup sets up for more half-court possessions and defensive adjustments. Chicago has the size with Vucevic to slow things down inside, and Philadelphia has leaned on Tyrese Maxey and Kelly Oubre for offense but doesn’t always get consistent production beyond them. With both teams capable of tightening up defensively in a statement-type game, the pace should be more controlled than the number suggests, keeping the total under.

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