Philadelphia 76ers vs. Detroit Pistons Picks and Prediction for Friday, November 14, 2025

By: Chris King Published 11/14/2025, 10:23 AM ET
76ers vs. Pistons Prediction
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It’s a matchup of Eastern Conference teams on the parquet floor in the Motor City as the Philadelphia 76ers clash with the Detroit Pistons Friday night and we have things covered with our 76ers vs. Pistons prediction. Philadelphia slipped past Boston 102-100 at home Tuesday night in their previous game, winning outright as a 1.5-point underdog. Detroit dropped the Bulls 124-113 at home in their previous game Wednesday night, winning outright as a 2.5-point underdog. In the all-time regular season series between the teams, the 76ers own a 234-161 advantage but the Pistons have won two straight meetings, including a 111-108 road win in the first meeting this season November 9. Read more about this 76ers vs. Pistons prediction! No air balls hereβ€”only slam dunks with our NBA Picks!

Philadelphia Looking to Pick Up Road Win

Philadelphia had dropped three of their previous four games before edging Boston at home Tuesday night in their previous contest. The 76ers entered Thursday 7-4 on the year and stood tied with the Knicks for the top spot in the Atlantic Division. Against Boston, Philadelphia led by one after the opening quarter and took a 10-point advantage at the half only to get outscored 36-20 in the third quarter to trail by six. The 76ers trailed 92-84 with 6:15 to play but rallied to outscore Boston 18-8 the rest of the way, capped by Kelly Oubre’s offensive putback with 8.7 seconds to play, gave them the win. Philadelphia shot 42.9% from the floor, including 14 of 36 from three-point range, and overcame a 53-44 beating on the boards in the game. Justin Edwards led the 76ers with 22 points off the bench in the win.

On the year, the 76ers are 8th in the league in scoring offense with 120.5 points per game. The 76ers are 17th in rebounding as they collect 43.9 rebounds per contest, while they are 16th in assists by dishing out an average of 26.3 dimes a night. Philadelphia is 16th in the league in scoring defense, as they allow an average of 116.8 points a contest. Tyrese Maxey leads the 76ers with 32.1 points and 8.3 assists per game this season. VJ Edgecombe (15.4 points, 5.5 rebounds, 4.3 assists), Kelly Oubre Jr. (18 points, 5.5 rebounds), Quentin Grimes (17.3 points, 4.3 rebounds) and Joel Embiid (19.7 points, 5.5 rebounds) are solid secondary scoring options. Dominick Barlow, Jabari Walker, Andre Drummond, Justin Edwards, Adem Bona, Eric Gordon, Trendon Watford and Hunter Sallis are looked at to contribute in the rotation. Philadelphia is 16th in the league in field goal percentage as they shoot 46.9% from the floor as a team this season. The 76ers are 11th in threes per game as they drain 13.8 triples a contest, while they are 6th in three-point shooting by connecting on 38.6% of their attempts from beyond the arc. Philadelphia stands 12th in the league in free-throw shooting as they convert 79.7% of their attempts this season.

Key Injury Report for Philadelphia

  • F Paul George (knee) is out
  • C Embiid (knee) is out
  • G Edgecombe (back) is questionable

Pistons Shooting for Ninth Straight Win

Detroit ran their win streak to eight games as they took down the Bulls at home Wednesday night, avenging their season-opening loss to Chicago. The Pistons ran their record to 10-2 on the year and held a two-game lead over the Cavaliers for the top spot in the Central Division. Against Chicago, Detroit led wire-to-wire as they rolled to the victory. The Pistons were up 12 after the opening quarter, by 16 at the half and by as many as 23 en route to the win. Detroit shot 55.6% from the floor, including 13 of 30 from three-point range, and forced 21 Chicago turnovers in the contest. Paul Reed led the Pistons with 28 points, 13 rebounds, six assists and four steals in the win.

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On the year, the Pistons are 13th in the league in scoring offense as they average 118.5 points a game. Detroit is 3rd in rebounding with an average of 47.9 boards per contest and 18th in assists by dishing out 26.2 dimes a night. The Pistons are 6th in the league in scoring defense as they give up an average of 112.8 points per contest. Cade Cunningham leads the way offensively for the Pistons with 27.5 points plus 5.4 rebounds and 9.9 assists per game. Ronald Holland II (9.3 points, 3.8 rebounds), Ausar Thompson (13.9 points, 6.6 rebounds, 3.4 assists) and Isaiah Stewart (10.7 points, 6.7 rebounds) are good secondary scoring options. Jalen Duren (19.4 points, 12 rebounds), Tobias Harris (13.5 points, six rebounds), Tolu Smith, Duncan Robinson (12.3 points), Caris LeVert, Paul Reed, Daniss Jenkins, Javonte Green and Chaz Lanier are expected to be contributors for coach J.B. Bickerstaff. Detroit is 13th in the league in field goal percentage as they shoot 47.4% from the floor as a team. The Pistons are 27th in the league in threes per game as they hit 10.9 triples per contest while they are 20th in three-point percentage as they connect on 34.9% of their attempts from beyond the arc. Detroit is below average at the charity stripe, ranking 29th by shooting 73.2% at the line as a team.\

Key Injury Report for Detroit

  • G Jaden Ivey (knee) is expected to be out until mid-November.
  • F Harris (ankle) is out
  • G Ausar Thompson (ankle) is out.
  • Cunningham (hip) is questionable
  • Duren (ankle) is questionable
  • Stewart (ankle) is questionable

76ers vs. Pistons Pick

76ers vs. Pistons Spread Pick

  • Pistons -5.5 (4 units)

These teams met on Sunday with the Pistons taking a three-point win in the City of Brotherly Love. There are pieces to monitor ahead of this game as the status of Cunningham, Duren and Stewart for Detroit and Edgecombe for the 76ers are up in the air. Philadelphia won’t have Embiid and George in this contest, leaving Maxey to try to shoulder the load himself. The Pistons are clicking right now and they took down the Bulls even with Cunningham in street clothes. Detroit is a sparkling 5-1 at home on the season and with momentum on their side, you have to give them the upper hand in this contest.

76ers vs. Pistons Over/Under Pick

  • Under 233.5 (4 units)

Philadelphia entered Thursday night having seen the over post a 7-4 mark in their 11 games on the season. The 76ers are eighth in the league in scoring offense, sixth in offensive efficiency and 17th in tempo with an average of 100.2 possessions per game. Detroit stands 13h in offensive efficiency, 17th in scoring offense and 13th in tempo with 101.1 possessions per game. The Pistons have stayed under the number in six of their 12 games this season entering this one. We saw only 219 points in the first meeting between the teams this season and with injuries running rampant, look for this game to wind up short of the total as well.

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