Portland Trail Blazers vs. Memphis Grizzlies Picks and Prediction, Sunday, December 7th, 2025

By: Mark Ruelle Published 12/07/2025, 03:48 AM ET
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In this Blazers at Grizzlies prediction, the Blazers wrap up their four-game road trip with a trip to Memphis to take on the Grizzlies. The Blazers are 1-2 on the trip thus far and 9-14 overall. The Grizzlies are playing well, winners of four of their last five games to move to 10-13 overall. Read on for more in this Blazers/Grizzlies prediction and get our top NBA predictions to increase your bankroll!

Portland Wraps Up Road Trip

The Portland Trail Blazers will finish their longest road trip of the season thus far, hoping to finish with a .500 record on the four-game journey with a win over the Grizzlies on Sunday. The Blazers have battled hard this season as they juggle a lineup that is a mixture of veterans and young up-and-coming players. On Friday night, the Blazers hung with the Pistons for much of the night before falling 122-116. Three players dominated the scoring for the Blazers. Deni Avdjia led the way with 35 points, Jeremi Grant had 29, and Shaedon Sharpe finished with 28 points. The rest of the Blazers squad combined for just 24 points.

The Blazers will try to close out the four-game trip on a high note on Sunday night. They come into this game ranked 13th in the league in points per game. The Blazers are 19th in scoring margin. They are 16th in offensive efficiency and 28th in field goal shooting. The Blazers are 29th in the league in 3-point shooting. On the defensive end, the Blazers are ranked 25th in the NBA in points allowed per game. They are 20th in defensive efficiency and 23rd in field goal defense. The Blazers are 13th in 3-point defense. They are seventh in the league in rebounding and 28th in turnovers per game.

Key Injuries: G Jrue Holiday, G Scoot Henderson, and G Blake Wesley are out. C Donovan Clingan and G Matisse Thybulle are game-time decisions.

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Grizzlies Heating Up

The Memphis Grizzlies get set to host the Blazers, winners of four of their last five games. The streak has moved the Grizzlies up to the ninth spot in the Western Conference standings. The Grizzlies took down the Los Angeles Clippers at home on Friday night, 107-98. Down by four at the half, the Grizzlies won both the third and fourth quarters to pull away for the win. Cedric Coward led five Blazers in double-digit scoring with 23 points while adding 14 rebounds. Cam Spencer and Jaylen Wells had 17 points each. Jaren Jackson Jr. had 13 points, and center Zach Edey had 10 points and eight rebounds.

The Grizzlies are just a few years removed from earning the top seed in the Western Conference. Since then, the team has had trouble keeping key players healthy and has struggled with off-the-court issues. Thus far in 2025-26, things have been solid. The Grizzlies are 23rd in points per game in the league. They are 20th in scoring margin. The Grizzlies are 24th in offensive efficiency and 27th in field goal shooting. The team is also just 27th in 3-point shooting. The Grizzlies are 17th in the NBA in points allowed per game. They are 17th in defensive efficiency and 20th in field goal shooting. They are just 25th in the league in 3-point defense. The Grizzlies are 19th in the league in rebounding and 10th in fewest turnovers per game.

Key Injuries: F Brandon Clarke, G Ty Jerome, and G Scotty Pippen Jr. are out. G Ja Morant is a game-time decisions.

Trail Blazers vs. Grizzlies Pick

Point Spread Pick for Trail Blazers vs. Grizzlies 

  • Grizzlies -1 (4 units)

The Blazers are wrapping up their longest road trip of the season thus far. They have lost two of the first three contests, all against Eastern Conference foes. They face a Grizzlies team that has now won six of its last eight games. The availability of Morant will certainly impact the game. If he’s ready to go, that improves the Grizzlies' offense. Even if he is unable to go, the Grizzlies have enough firepower to handle the weary Blazers. Defensively, the Grizzlies are superior to the Blazers and have a huge rim protector in Edey waiting at the rim. This is critical against a Blazers team that is 13th in the NBA in points in the paint. The Grizzlies with make it seven wins in their last nine games.

Take the Grizzlies minus the points.

Over/Under Pick for Blazers at Grizzlies 

  • Over 235

The Blazers have scored at least 120 points in two of their last three games. The opposition has scored at least 120 points against them in three of the last four games. Don’t expect spry legs on the last leg of the road trip for Portland. The Grizzlies could be more electric with the possible return of Morant. They’ll take full advantage of the sloppy play of the Blazers, ranked 28th in turnovers per game. This one will sneak over the number.

Take the over.

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