San Antonio Spurs vs Los Angeles Lakers Picks, Odds, Preview, and Prediction, Wednesday, November 5, 2025
Use Code WWWC It’s a Western Conference duel between two top teams early in the season on Wednesday, Nov. 5. Read our San Antonio Spurs vs Los Angeles Lakers prediction along with our other NBA Picks. The Spurs are 5-1 and are coming off their first loss of the season as they fell victim to the Suns. The Lakers are currently on a four-game winning streak with their 6-2 record. Los Angeles earned a win over Portland without key players Luka Doncic, Austin Reeves and LeBron James. These two teams will meet with tip-off set for 10 P.M. EST.
Spurs lose first game of the season
San Antonio is 5-1 overall this season. The Spurs are one of four teams with one loss or better this season. The Spurs are 2-1 when they have played on the road. They started the year with five straight wins and are coming off their first defeat of the year.
In their last game, the Spurs lost 130-118 to the Suns on the road on Sunday, Nov. 2. San Antonio was neutralized from the beginning as they never led from midway through the first quarter to the finish. Spurs shot just 46% from the field while they allowed the Suns to hit 58% from the field and 57% from behind the arc. Victor Wembanyama was not allowed to get going as he finished with just nine points on 4-for-14 shooting. Stephon Castle led the team with 26 points on 10-for-16 shooting.
Wembanyama leads the team with 26.7 points and 13.7 rebounds per game. Castle is the top assist man with 5.3 per game.
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San Antonio is averaging 118.3 points per game, which ranks 13th. They are the eighth-best shooting team, making 49.8% from the field. The Spurs are hitting 35.2% from behind the arc, placing them 15th.
On defense, the Spurs are allowing 108.3 points per game, which is the best mark in the league. They are allowing 44.5% from the field, placing them fourth. The Spurs rank third-worst in 3-point shooting, allowing 39.3% from deep.
San Antonio ranks seventh in offensive efficiency. They are also the second-best defensive efficient team, while they also rank fifth-best in rebounding.
San Antonio is 4-1-1 against the spread this season. They are 3-1-1 against the spread when they have been favored. The Spurs are 1-1-1 against the spread when they have played on the road. The under is 4-2 when the Spurs have played. The over is 2-1 when they have played on the road.
Luke Kornet, De’Aaron Fox, and Dylan Harper are all out of Wednesday’s game. Jermey Sochan, Lindy Waters III, and Kelly Olynyk missed the team’s last game and are questionable for this one.
Lakers riding 4-game winning streak
The Lakers are 6-2 overall this season. They started the year 2-2 with wins over Minnesota and Sacramento, but they suffered losses to Golden State and Portland. The Lakers have won four straight games coming into Wednesday’s game.
In their last game, the Lakers defeated Portland 123-115 on Monday, Nov. 3. The Lakers won the game without top players Austin Reeves, Luka Doncic, and LeBron James. Los Angeles outscored Portland by nine points in the second half to secure the win. They shot 58.8% from the field and 39.1% from behind the arc. The Lakers' defense was key as they forced Portland to shoot just 9-for-40 from 3-point land. DeAndre Ayton led the team with 29 points on 14-for-19 in his return to his former team.
The Lakers are averaging 119.8 points per game, which ranks 10th in the league. They are the best shooting team in the sport, making 52.9% from the field. Los Angeles is also hitting 33.1% from behind the 3-point line, which ranks 22nd.
On defense, the Lakers are allowing 116.8 points per game, which ranks 15th. They are the 19th-ranked defense, allowing 47.3% from the field. Los Angeles is also the 12th-ranked 3-point defensive team, giving up 34.9% from behind the arc.
The Lakers are the eighth-ranked offensive efficiency team. They rank 19th in defensive efficiency, while they are also the 10th-ranked rebounding team.
The Lakers are 6-2 against the spread this season. They are 2-2 against the spread when they have played at home. The Lakers are 4-2 against the spread as an underdog and 2-0 as a favorite. The over is 7-1 when Los Angeles has played this season. The over is 4-0 when they have played at home.
Lebron James and Gabe Vincent are out for Wednesday’s game. Luka Doncic, Austin Reaves and Maxi Kleber are missed Monday’s game and are questionable for Wednesday’s game.
San Antonio Spurs vs Los Angeles Lakers Picks
Spurs vs Lakers Spread Pick
- San Antonio Spurs +2.5 (5 Units)
The Spurs are coming off their first loss of the season to the Suns. It was a poor game as the defense did not live up to the standards. Victor Wembanyama was unable to get going either, and I think both of those things will turn around in this game. The Lakers are ranked 19th in defensive efficiency, and they will struggle at defending the lane and around the rim, an area where Wembanyama feasts. The defense for San Antonio has been great this year, and they have the pieces to slow down Luka Doncic and Austin Reeves. The Spurs rank second-best in defensive efficiency, and they are the best defensive scoring team. The combination of a strong defense and interior scoring will lead San Antonio to a big win on the road.
Take the Spurs to cover.
Spurs vs Lakers Over/Under Pick
- Under 229.5 (5 units)
The Lakers are the ninth slowest team in the league, and the over is 7-1 this season, but this game will be a low-scoring one. The Lakers, with their slow pace, along with the Spurs being the best defensive team, will be a game that will struggle for long runs and sustained scoring. The under is 4-2 when San Antonio has played this year.
Take the under on Wednesday.
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