San Antonio Spurs vs. Portland Trail Blazers Picks and Prediction for Wednesday, November 26, 2025
San Antonio Spurs (11-5) vs. Portland Trail Blazers (8-10)
The San Antonio Spurs head to Moda Center in Portland, OR, on Wednesday night to square off against the Portland Trail Blazers in the NBA Cup showdown, and we’ve got you covered with our Spurs vs. Trail Blazers prediction.
The Trail Blazers are 2-1 in the NBA Cup and tied with the Denver Nuggets for the top spot in West Group C, while the Spurs sit at 1-1. San Antonio meets Portland for the first time this season. In 2024-25, the Spurs went 3-1 SU and 2-2 ATS against the Trail Blazers, and three of those four tilts went over the total.
Let’s take a closer look at this Spurs vs. Trail Blazers prediction, one of our NBA picks for Wednesday’s nine-game slate. The tip-off at Moda Center is set at 10:00 PM ET, and the Trail Blazers open as 2.5-point favorites with a total of 238.5 points.
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The Spurs have injury problems
The San Antonio Spurs (11-5; 8-8 ATS; 8-8 O/U) put an end to their three-game winning streak last Sunday. After beating the Sacramento Kings 123-110, the Memphis Grizzlies 111-101, and the Atlanta Hawks 135-126, the Spurs suffered a 111-102 defeat at the Phoenix Suns.
The Spurs blew an 11-point lead in Phoenix. They committed 13 more turnovers than the Suns (19-6) and made just 10 of their 34 shots from deep. De’Aaron Fox led the way with 26 points and five rebounds, while Julian Champagnie double-doubled with 10 points and 12 boards.
Victor Wembanyama (26.2 PPG, 12.9 RPG) missed his fourth straight game with a calf injury. He’s expected to miss multiple weeks, while Stephon Castle (17.3 PPG, 7.5 APG) will miss a couple of weeks with a hip injury. Dylan Harper (14.0 PPG) is on the shelf, too.
With those three guys on the sidelines, the Spurs heavily lean on Fox, who’s scored at least 26 points in four straight outings. The Spurs tally 118.4 points per 100 possessions (7th in the NBA) and allow 112.3 points in return (5th).
Key Injuries for Spurs:
- G Dylan Harper (calf) is questionable.
- G Stephon Castle (hip) is out 1-2 weeks.
- F Victor Wembanyama (calf) is out for multiple weeks.
The Trail Blazers hope to stay on the winning path
The Portland Trail Blazers (8-10; 9-8-1 ATS; 12-6 O/U) just finished their three-game road trip with a 2-1 SU and ATS record. They sandwiched a heavy 122-95 defeat at the mighty Oklahoma City Thunder with a pair of wins over the Golden State Warriors, 127-123, and the Milwaukee Bucks, 115-103.
Last Monday, the Trail Blazers took full advantage of Giannis Antetokounmpo’s absence and cruised past the Bucks. Portland outrebounded Milwaukee 48-39 while going 18-for-43 from deep, and Jerami Grant led the way with 35 points.
The Trail Blazers have injury worries, too. Jrue Holiday (16.7 PPG, 8.3 APG) missed six straight games and will be sidelined for at least a couple of weeks. Scoot Henderson (hamstring) has yet to make his season debut, while Shaedon Sharpe (22.6 PPG) missed four straight games with a calf injury.
Sharpe is questionable for Wednesday’s clash against San Antonio. Should he remain on the shelf, the Blazers will continue to rely on Grant (19.5 PPG) and Deni Avdija (24.9 PPG). Portland scores 116.2 points per 100 possessions (tied for 17th in the NBA) and allows 118.2 points in return (21st).
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Key Injury Report for Trail Blazers:
- G Shaedon Sharpe (calf) is questionable.
- G Scoot Henderson (hamstring) is out 3-4 weeks.
- G Jrue Holiday (calf) is out 1-2 weeks.
Spurs vs. Trail Blazers Pick
Spread Pick for Spurs vs. Trail Blazers
- San Antonio Spurs +2.5 (5 units)
Both teams are without some very important players. Interestingly, the Spurs have done a great job on the glass in Victor Wembanyama’s absence, so I’m backing San Antonio in this game.
Portland is second in the NBA in offensive rebound percentage (33.0%), and the Spurs have to keep the Blazers off the glass. San Antonio is third in defensive rebound percentage (77.0%).
The Spurs look like a better defensive unit than the Blazers, who have allowed 122 or more points in six of their previous seven outings. I think San Antonio has enough weapons to upset Portland at Moda Center.
Over/Under Pick for Spurs vs. Trail Blazers
- Under 238.5 (5 units)
The Trail Blazers play fast, but they are not a great shooting team by any stretch of the imagination. Portland is fifth in the NBA in pace (102.1 possessions per 48 minutes) and 27th in 3-point percentage (32.7%).
The Spurs have struggled to defend the 3-point line thus far (39.2%, 28th). Yet, they register 99.2 possessions per 48 minutes (22nd) and are in the middle of the pack in both 3-point rate (.423) and 3-point percentage (36.1%). I expect the Spurs to slow things down as much as possible, so give me the under.
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