New York Yankees vs. Minnesota Twins, Picks and Prediction, Tuesday, September 16, 2025
Use Code WWWC New York (83-66) will be trying to pick up their second consecutive series win when they visit Target Field on Tuesday night to face Minnesota (65-84) in the second game of their three-game series at 7:40 PM. ET. Read on to find out which team picks up the win in this Yankees vs. Twins prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Cam Schlittler, 3-3, 3.05 ERA, will get the start for the Yankees. The Twins will counter with Zebby Matthews, 4-5, 5.06 ERA.
New York is 9-1 in its last 10 games against Minnesota.
**This preview was written before Monday’s game was played.**
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New York Trying To Keep AL East Title Hopes Alive
The Yankees bounced back from their series loss to Detroit with a series win over Boston. They are second in the AL East standings, four games behind Toronto, and will try to cut into the Blue Jays’ lead with a win on Tuesday.
New York averages 5.19 runs per game, which leads the league. Their .249 batting average is 12th in the league. Their .329 on base percentage is fifth, while their .454 slugging percentage leads the league.
Aaron Judge has been the most consistent batter for New York. He leads the team with a .326 batting average, 48 home runs, and 102 RBI.
New York is giving up 4.33 runs per game, which is 15th in the league. Opponents have a .232 batting average against the Yankees, which is fifth in the league. Their 4.00 ERA is 16th, while their 1.27 WHIP is 14th.
In his last start, Schlittler gave up five hits and one run in six innings, leading to a 9-3 win over the Tigers. He is 0-0 with a 1.80 ERA in one game against Minnesota.
Minnesota Trying To End Slump
The Twins have struggled in recent weeks, and they’ve lost 10 of their last 13 games. They have also lost six of their last eight home games. They will try to turn things around and pick up a rare win over New York when they play on Tuesday.
Minnesota averages 4.24 runs per game, which is 24th in the league. Their .239 batting average is 22nd in the league. Their .313 on base percentage is 21st, while their .399 slugging percentage is 16th.
Byron Buxton has been the big bat for Minnesota. He leads the team with a .270 batting average, 31 home runs, and 76 RBI.
Minnesota is giving up 4.84 runs per game, which is 24th in the league. Opponents have a .260 batting average against the Twins, which is 26th in the league. Their 4.61 ERA is 24th, while their 1.33 WHIP is 23rd.
In his last start, Matthews gave up seven hits and five runs in 4.2 innings, leading to a 12-2 loss to the Angels.
New York Yankees vs. Minnesota Twins Pick
Run Line Pick for Yankees vs. Twins
- New York Yankees -1.5 (4 Units)
The Yankees have won three of their last four road games, while the Twins have lost six of their last eight home games. New York has the edge here because they’ve had a lot of success against right-handers, and they’re going up against Matthews, who struggled on the mound in recent starts, giving up nine runs in his last three starts. With Minnesota’s bullpen also struggling, they will have a hard time slowing down the Yankees.
Minnesota won’t be as successful offensively because they’ve struggled against right-handers, and they’re going up against Schlittler, who gave up six runs in his last five starts. He gave up three runs in his last three road starts, and won’t have trouble keeping Minnesota’s offense in check. Take New York on the run line.
Over/Under Pick for Yankees vs. Twins
- Under (4 Units)
The Yankees played under the total in two of their last three games, while the Twins played under the total in their last two games. New York averages 5.14 runs per game and 4.33 runs per game in their last three games. They’re batting .246 against right-handers, and they’re facing a starter who gave up six runs in his last three home starts. The Twins average 4.24 runs per game and five runs per game in their last three games. They’re batting .239 against right-handers, and they’re facing a starter who gave up three runs in his last three road starts. Don't expect these teams to score enough runs to push the score over the total. The Twins and Yankees played under the total in two of their last three meetings.
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