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Current NFL Outlook — Week 4
NFL Week 4 begins Thursday, October 1 with Pittsburgh visiting Cleveland for an AFC North matchup and continues with a 15-game Sunday and Monday slate. Sunday starts early with Indianapolis and Washington meeting in London before a full afternoon schedule, Sunday Night Football between Detroit and Carolina, and Atlanta visiting New Orleans on Monday night.
Quarterback availability is one of the biggest factors shaping this week's NFL predictions. Tampa Bay will turn to rookie Jalon Daniels against Green Bay with Baker Mayfield sidelined by a dislocated thumb. Washington will again be without Jayden Daniels against Indianapolis, while Chicago remains without Caleb Williams as the Bears prepare to host the Jets. Those changes have already affected several point spreads and totals, making current injury information especially important before placing a wager.
Other Week 4 matchups include Jacksonville visiting Cincinnati, New England traveling to Buffalo, the Rams facing Philadelphia, Kansas City meeting division rival Las Vegas, the Chargers visiting Seattle, and Denver taking on San Francisco. With several spreads sitting around key NFL numbers such as 3 and 7, bettors should pay close attention to late-week line movement rather than assuming an early number will still be available on game day.
Our NFL predictions are updated throughout the week as injury reports, quarterback news, weather forecasts and betting lines develop. Check the matchup previews above for our latest NFL picks, predictions, odds, line movement and best bets for every Week 4 game.