Arizona Cardinals vs. Dallas Cowboys, Preview, Odds, Picks and Prediction for Monday, November 3rd, 2025
Use Code WWWC The Arizona Cardinals (2-5, 4-3 ATS, 4-3 O/U) take on the Dallas Cowboys (3-4-1, 4-4 ATS, 6-2 O/U) in an NFC meeting on Monday evening, and we have you covered with the prediction. The Cardinals were dealt a defeat by the Packers two weeks ago and had their bye last week. The Cowboys dropped a road meeting against the Broncos in their previous action. These squads last met in 2023 in a game Arizona won.
Can the Cardinals end their losing streak with a road win on Sunday? Check out the Cardinals vs. Cowboys prediction. Do you need a boost in your handicapping? Try our NFL Betting Picks!
Arizona Hopes to Get Kyle Murray Back on Monday
The Arizona Cardinals are eager to get back on the field. Arizona had its bye last week. The Cardinals were 2-0 to begin the season but have not won a game since, dropping five straight games. There have been several narrow losses in the slide, including a 23-20 defeat to the Seahawks and a 31-27 road defeat against the Colts. Arizona was charged with a 27-23 home loss by the Packers before their bye on October 19th. They were seven-point dogs in that one. The Cardinals have covered the spread in three of their past five games.
Kyler Murray has not played the last two games due to a foot injury. They had Jacoby Brissett under center in his absence. Murray has recovered, but Brissett will likely start. Brissett isn't as speedy as Murray, but the veteran has 275+ passing yards in his two starts and the offense has been less productive under Murray, averaging just 20.6 points per game and 288.4 yards per game in his five starts, compared to 25 points per game and 365 total yards per game in Brissett's two starts.
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Trey Benson leads all Arizona running backs with 160 rushing yards. The 23-year-old is injured and will not play. Bam Knight rushed for 57 yards against the Packers and has amassed 102 rushing yards. Trey McBride has been one of the best tight ends in the NFL. The 25-year-old has surpassed 60 receiving yards on five occasions and has 421 yards. Marvin Harrison Jr. is a threat, bringing in 396 receiving yards. The Arizona offense recorded 330 yards in its most recent action in the defeat against the Packers, and is averaging 310 yards per game.
The Cardinals' defense is keeping them in games. The unit has conceded 23 or fewer points in five of seven games. They held Green Bay to only 262 total yards and are conceding an average of 335 yards per game. Mack Wilson Sr. is having a superb season, making a combined 53 tackles and has deflected 6 six passes. The pass defense is marked 25th, while the rush defense is a strength, coming in at 12th.
Arizona is averaging 21.9 points on the season, ranking them 20th. The Cardinals are keeping opponents to an average of 22 points, placing them 15th.
Cowboys Defense Exposed in Another Defeat
The Dallas Cowboys are seeking the .500 mark in this one. Dallas has played in several close games, including an OT win against the Giants. They dropped a 30-27 decision against the Panthers earlier this month. Last week was not one of those close games. They were charged with a 44-24 road loss against the Broncos last week in a clash that had the Cowboys as four-point dogs. The Cowboys have covered the spread in two of their three home games.
Dak Prescott has been outstanding most of the season, but was contained by the Broncos last week, amassing 188 passing yards and tossing two picks. The star QB has posted 2069 passing yards and a 16:5 TD to INT ratio on the season.
Javonte Williams has been dangerous. The 25-year-old running back reached 50 rushing yards on six occasions this season and has managed 633 rushing yards on the season. The receiving core is stacked. George Pickens continues to be targeted more than anyone. The star WR has surpassed 100 yards in two of his past five games and has 685 receiving yards. TE Jake Ferguson has been outstanding with 51 catches and seven TDs. CeeDee Lamb has reported 406 receiving yards. The Dallas offense managed 339 total yards against a stingy defense last week. They are posting an average of 384 yards per game.
The Cowboys' defense continues to be a huge weakness. They rank near the bottom in most categories. The unit conceded 426 total yards against Denver and is squandering an average of 405 yards per game. Kenneth Murray Jr. has been one of the few positives on defense, posting 58 combined tackles. The pass defense is 31st, while the rush defense is marked 29th.
Dallas is scoring an average of 30.8 points, ranking them second. The Cowboys are squandering an average of 31.3 points, pegging them 31st in the NFL.
The Cowboys will miss safeties Donovan Wilson (elbow/shoulder) and Alijah Clark (ribs), along with CB Shavon Revel (knee).
Cardinals vs. Cowboys Pick
Spread Pick for Cardinals vs. Cowboys
- Arizona Cardinals +3.5 (5 units)
The Arizona Cardinals are staying with Brissett, who has been more productive as a passer, and he faces a banged-up Dallas secondary. Brissett has recorded 599 passing yards in two games. The Dallas Cowboys have a potent offense but no defense. They have only won two of their past six games.
Furthermore, Arizona is going to expose a putrid pass defense. Arizona opts for the pass in 60% of its plays. The Cowboys are squandering an average of 258 passing yards per game, ranking them 31st in the entire NFL. Arizona’s top strength has been the rushing offense, and the Cowboys' rush defense is a mammoth weakness, standing 29th. The Cardinals have the better defense in this matchup. Prescott will do his usual damage in the air, but the running game will have trouble against a stingy Cardinals rush defense ranked 12th.
Over/Under Pick for Cardinals vs. Cowboys
- Over 54 (5 units)
I expect a shootout. The under is never safe when Dallas is playing. They have given up 30 or more points in five of their past seven games and an average of 33 points at home. Arizona has scored 50 points in its past two games with Brissett at quarterback, and he's going to get the ball again.
In addition, the Dallas offense is potent. They are 2nd in the NFL in total yards and 1st in passing yards. I expect more success in the air against a subpar Cardinals pass defense that is pegged 25th in the NFL. Also, these squads have quick offenses. Arizona is 11th in plays per game, while Dallas is sixth. The over is a convincing 5-0 in the Cowboys' previous five games.
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