Arizona Cardinals vs. Seattle Seahawks, Odds, Preview, Picks and Prediction, Sunday, November 9, 2025

Arizona (3-5) will be trying to pick up their second consecutive road win when they visit Lumen Field on Sunday afternoon to face Seattle (6-2) at 4:05 PM. ET. Read on to find out which team picks up the win in this Cardinals vs. Seahawks prediction. Looking to win big this football season? We have the best NFL Picks to help you out!

The Cardinals are coming off a 27-17 win over Dallas as 3.5-point underdogs. The Seahawks are coming off a 38-14 win over Washington as 2.5-point favorites.

Seattle is 9-1 in its last 10 games against Arizona. The Seahawks won the first meeting of the season, 23-20 in Week 14 as Jason Myers kicked a 52-yard field goal for the game-winner as time expired.

Cardinals vs. Seahawks Matchup

Cardinals Going For Series Split

The Cardinals snapped their five-game losing streak with a win over the Cowboys on Monday night. They lost a three-point game the last time they faced the Seahawks, and will try to earn a series split when they play on Sunday.

Arizona averages 22.5 points per game, which is 19th in the league. They throw for 202.5 yards and rush for 111.5 yards per game.

Kyler Murray has completed 68 percent of his passes for 962 yards, six touchdowns, and three interceptions. He was placed on the IR this week and is expected to miss at least four games.

Jacoby Brissett has played well while filling in for Murray and was named the starter for the rest of the season. He has completed 65 percent of his passes for 860 yards, six touchdowns, and one interception. Emari Denercado has 22 carries for 169 yards, while Marvin Harrison Jr. has 31 catches for 492 yards and three touchdowns.

Arizona is giving up 21.4 points per game, which is 11th in the league. They’re giving up 231.8 passing yards and 103.6 rushing yards per game. They'll miss three defensive starters as CB Max Melton (concussion), LB Mack Wilson (ribs) and CB Will Johnson (back/hip) are out.

Seahawks Going For Fourth Consecutive Win

The Seahawks bounced back from their loss to Tampa Bay with wins over Jacksonville, Houston, and Washington. They will try to keep the momentum going and pick up their fourth straight win when they play on Sunday.

Seattle averages 28.9 points per game, which is fifth in the league. They throw for 255.1 yards and rush for 103.9 yards per game.

Sam Darnold has completed 70 percent of his passes for 2,084 yards, 16 touchdowns, and five interceptions. Kenneth Walker III leads the team with 106 carries for 472 yards and three touchdowns, while Jaxon Smith-Njigba leads the team with 58 catches for 948 yards and four touchdowns. They also added wide receiver Rasheed Shaheed from the Saints in a draft deadline trade on Tuesday. Shaheed is expected to suit up for the Seahawks on Sunday. Shaheed has 44 catches for 499 yards and two TDs with the Saints and was added for fourth and fifth-round picks in the 2026 draft.

Seattle is giving up 18.8 points per game, which is fifth in the league. They’re giving up 218 passing yards and 85.9 rushing yards per game.

Cardinals vs. Seahawks Picks

Point Spread Pick for Cardinals vs. Seahawks

• Seattle Seahawks -6.5 (4 Units)

The Seahawks have won six of their last seven games, while the Cardinals have lost five of their last six games. Seattle has the edge here because they’re very good offensively, with one of the best passing games in the league. The Cardinals have played well defensively, but they’ve been unable to slow down the pass, giving up more than 230 yards per game, so expect them to have a hard time slowing down the Seahawks.

Arizona will have a hard time keeping up with Seattle because they’re not as good offensively. They don’t run the ball well and rely heavily on their passing game. With the Seahawks not having to worry about the Cardinals beating them on the ground, expect them to keep pressure on Brissett and force him to make costly mistakes. Go with Seattle to cover the spread..

Over/Under Pick for Cardinals vs. Seahawks

• Under 45.5 (4 Units)

The Cardinals average 22.5 points per game. They throw the ball 59 percent of the time with the 20th-ranked passing attack in the league, and they’re facing a team that is 19th against the pass and is giving up 18.8 points per game. The Seahawks average 28.9 points per game. They throw the ball 50 percent of the time with the fourth-ranked passing attack in the league, and they’re facing a team that is 23rd against the pass and is giving up 21.4 points per game. Don’t expect these teams to score enough points to push the score over the total. The Cardinals and Seahawks played under the total in four of their last five meetings.