Arizona Cardinals vs Seattle Seahawks Picks and Predictions for Sunday, November 8, 2026

Arizona heads to Seattle on Sunday for a 4:25 pm ET kickoff at Lumen Field. FOX has the broadcast. The Cardinals (3-5, 4th NFC West) arrive after beating Dallas 33-30 in overtime, while the Seahawks (4-4, tied for 2nd NFC West) lost 34-17 to Chicago on Monday night. Neither team has strung together consecutive wins recently. Arizona has won three road games, though. Seattle is 3-2 at home, and this division matchup gives both teams a chance to gain ground. Cash a winner with our free NFL picks.

Arizona Cardinals Coming Off an Overtime Win

Arizona needed extra time in Dallas. The Cardinals pulled out a 33-30 victory last Sunday, bouncing back from a 30-16 loss to Denver. That's two wins in three games, but don't mistake the improvement for a complete turnaround. Arizona still gives up nearly 30 points per game. The defense has surrendered 238 through eight outings, including 45 against Detroit in October. Those numbers put plenty of pressure on the offense.

Gardner Minshew II has 188 passing yards and 3 touchdowns. His completion rate sits at 73.9%. Trey McBride has been the busiest target, catching 66 passes for 544 yards and five touchdowns, while Michael Wilson has added 486 receiving yards. Tyler Allgeier leads the ground game with 323 yards. The Cardinals have some bite defensively, too. Budda Baker has 3.5 sacks, and Jack Gibbens leads the team with 60 tackles.

Injuries: Kendrick Bourne is out. Walter Nolen III, Jon Gaines II, Bam Knight and Jeremiyah Love are questionable.

Seattle Seahawks Looking to Shake Off Monday's Loss

Chicago went into Lumen Field on Monday and beat Seattle 34-17. Ugly timing for the Seahawks. They had held Kansas City to three points the previous week, then watched the Bears put up 34. Seattle has now dropped three of its last four, with narrow losses to Denver and San Francisco preceding that win over the Chiefs. The Seahawks are scoring 23.1 points per game while allowing 19.9. Monday's defensive performance was well below that standard.

Jaxon Smith-Njigba has been tearing through secondaries. He's caught 64 passes for 985 yards and nine touchdowns, easily Seattle's top receiving numbers. Sam Darnold has thrown for 1,478 yards with 10 touchdowns, but nine interceptions have hurt his season. Emanuel Wilson leads the rushing attack with 403 yards and three scores. Then there's Ernest Jones IV. His 81 tackles lead Seattle, while Leonard Williams has three sacks and carries a questionable designation.

Injuries: Rashid Shaheed, Velus Jones Jr., Charles Cross, Leonard Williams and Brandon Pili are questionable.

Key To The Game

Can Arizona slow Smith-Njigba down? That's the first problem. He's averaging 123.1 receiving yards per game, and the Cardinals have already allowed 238 points. Seattle's own concern is Darnold's nine interceptions. Minshew II does not have any picks in limited action. A turnover or two could swing this one quickly.

Arizona Cardinals vs Seattle Seahawks Game Pick

• Arizona Cardinals +10.5

Arizona hasn't won consecutive games yet, but the Cardinals have covered plenty of ground away from home, winning three of five road trips. Seattle is favored by 10.5 despite dropping three of its last four. That's a lot to lay with a quarterback who has nine interceptions. Minshew II can move the ball through McBride, and Arizona just scored 33 in Dallas. The Cardinals' defense is a concern, especially against Smith-Njigba, but Seattle's recent results don't justify expecting an easy afternoon. I'll take Arizona and the points, even if the Seahawks win outright.

Arizona Cardinals vs Seattle Seahawks Over/Under Pick

• Over 42.5

Arizona's defense has allowed 238 points in eight games. That works out to nearly 30 every Sunday, and Smith-Njigba is having the kind of season that can punish loose coverage. Seattle just surrendered 34 to Chicago, too. Minshew II has McBride underneath and Wilson downfield, so the Cardinals should find room to answer. Darnold's interceptions could interrupt drives, but both clubs have shown enough scoring ability to clear a modest total. The last Arizona game finished 33-30, while Seattle's latest ended 34-17. I'll play over 42.5, with both offenses contributing to the scoring.