Arizona Cardinals vs Tampa Bay Buccaneers Prediction and Picks - November 30, 2025
NFL action on Sunday afternoon, and we have an Arizona Cardinals vs Tampa Bay Buccaneers Prediction ready to rock and roll. Arizona is off a 27-24 home loss to the Jaguars to fall to 3-8 on the year. The Buccaneers have gone 6-5 on the year and they are off a 34-7 loss to the Rams on the road. These teams last met back in 2-22 and Tampa Bay won that game on the road by a score of 19-16 in OT. Read on to see our Cardinals vs Buccaneers prediction.
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Cards Take Tough Loss To Jags In OT
Arizona’s most recent game was a 27-24 overtime loss to Jacksonville on November 23, a gut punch at home where Jacoby Brissett threw for 317 yards and a touchdown but couldn’t finish off a late drive in OT. Michael Wilson was the bright spot with 10 catches for 118 yards, while Greg Dortch hauled in a 39-yard score in the fourth quarter. The Cardinals tied it at the end of regulation with a Chad Ryland field goal, but Trevor Lawrence and the Jaguars escaped with a 52-yard kick in overtime.
The Cardinals’ offense has been middle of the pack, averaging 332.8 yards per game and 22.5 points per contest. Brissett has been steady but unspectacular, throwing for nearly 1,900 yards with 11 touchdowns and just three interceptions. Trey McBride has been the go-to target, leading the team with 797 receiving yards and seven scores, while rookie Marvin Harrison Jr. has missed time but remains a key piece when healthy. The ground game has been thin, averaging only 101.1 rushing yards per game, with Emari Demercado sidelined and Michael Carter filling in.
Defensively, Arizona has struggled to close games, giving up 25.7 points per game (25th in the league) despite ranking 19th in total yards allowed. Budda Baker continues to lead the secondary with 78 tackles, and rookie Walter Nolen III provided a spark with a fumble return touchdown against Jacksonville. The Cardinals have forced just nine takeaways all season, a number that has kept them from flipping momentum in tight contests. Against Tampa Bay, they’ll need to generate turnovers and protect Brissett to avoid another close loss.
Bucs Get Trounced By The Rams
Tampa Bay’s last outing was a 34-7 loss to the Rams on November 23, a primetime game where Matthew Stafford threw three touchdowns and Davante Adams scored twice. Baker Mayfield struggled before leaving with a shoulder injury, throwing two interceptions and just 60 total yards. Teddy Bridgewater took over in the second half but couldn’t spark the offense, as the Buccaneers managed only 193 total yards and were shut out in three quarters.
The Buccaneers’ offense has been inconsistent, averaging 319.5 yards per game and 23.5 points per contest. Mayfield has thrown for 2,406 yards with 18 touchdowns and five interceptions, but his health is now a concern heading into Week 13. Rachaad White has been steady in the backfield with 414 rushing yards and four scores, while Emeka Egbuka has emerged as a reliable target with 749 receiving yards and six touchdowns. Tampa Bay has protected the ball well, committing only nine turnovers, but their inability to sustain drives has hurt them in recent weeks.
Defensively, Tampa Bay has been vulnerable, allowing 25.8 points per game (26th in the league) and ranking 27th against the pass at 243.5 yards per game. The run defense has been stout, giving up just 97.6 rushing yards per contest, but the secondary has been picked apart repeatedly. Safety Tre’von Smith leads the team with 85 tackles, while Yaya Diaby has chipped in five sacks. The Buccaneers have forced only 10 takeaways, and their inability to flip field position has compounded offensive struggles. Against Arizona, they’ll look to lean on their run defense and hope Mayfield or Bridgewater can stabilize the offense.
Arizona Cardinals vs Tampa Bay Buccaneers Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Cardinals vs Buccaneers Spread Pick
- Arizona +3.5 (5 Units)
Arizona +3.5 has appeal because the Cardinals have quietly been competitive in tight games, even against stronger opponents. Jacoby Brissett has managed the offense well, throwing for over 1,800 yards with just three interceptions, and Trey McBride has emerged as a reliable weapon with nearly 800 receiving yards. While the rushing attack has been thin, Michael Wilson and Greg Dortch have stepped up to keep drives alive. Defensively, Arizona has held opponents to 337 yards per game, and Budda Baker continues to anchor a unit that can bend without completely breaking. Against a Tampa Bay team that has struggled to find rhythm offensively, the Cardinals have the balance to keep this within a field goal.
On the other side, Tampa Bay’s offense has been inconsistent, especially with Baker Mayfield battling injury. Even though they average 23.5 points per game, the Buccaneers have been prone to stalled drives and rank just 20th in total offense. Their defense has been vulnerable against the pass, giving up 243.5 yards per game (27th in the league), which plays into Arizona’s strength through the air. With the Cardinals’ defense capable of forcing mistakes and their offense efficient enough to exploit Tampa Bay’s secondary, taking the points with Arizona +3.5 feels like the sharper side in a matchup that profiles as close throughout.
Cardinals vs Buccaneers Over/Under Pick
- Under 45 (4 Units)
The Under 45 makes sense here because both Arizona and Tampa Bay have been inconsistent offensively and rely more on defenses that bend but don’t completely break. The Cardinals average just 22.5 points per game with a limited rushing attack, while Tampa Bay sits at 23.5 points per contest but has struggled to sustain drives, especially with Baker Mayfield’s health in question. Arizona’s defense allows 25.7 points per game, and Tampa Bay gives up 25.8, yet both units have shown the ability to tighten in the red zone. With neither team built for explosive scoring and both prone to long, grinding possessions, this matchup profiles as a slower-paced game that stays below the total.
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