Atlanta Falcons at Arizona Cardinals Prediction, Picks, and Odds Movement for December 21 2025
Use Code WWWC Falcons vs Cardinals picks highlight a matchup that comes at an interesting point for both teams, and this breakdown ties directly into my broader approach to NFL predictions as we head deeper into the schedule.
Quick Picks and Prediction
- Spread: Cardinals +2.5
- Total: Over 47
- Projected Score: Falcons 28, Cardinals 27
Odds and Line Movement
| Team | Opening Spread |
|---|---|
| Atlanta | -2.5 |
| Arizona | +2.5 |
| Team | Current Spread |
|---|---|
| Atlanta | -2.5 (-115) |
| Arizona | +2.5 (-105) |
Line Movement - Spread
| Date | Atlanta | Arizona |
|---|---|---|
| 12/16 | -2.5 (-115) | +2.5 (-105) |
| 12/15 | -1.5 (-115) | +1.5 (-105) |
Line Movement - Total
| Date | Over | Under |
|---|---|---|
| 12/15 | 47 (-115) | 47 (-105) |
| 12/14 | 45 (-110) | 45 (-110) |
Key Matchups and Handicap
This is the first meeting between these teams since Arizona earned a 25-23 home win in November 2023. Atlanta comes in with extra preparation time after a road win at Tampa Bay last Thursday, but that extra rest has not translated into betting success when the Falcons are favored. Atlanta is 1-5 against the spread as a favorite this season, losing all five of those games outright.
Arizona has dropped six straight games and sits at 1-5 against the number during that stretch, but last week’s loss in Houston was more competitive than the final score suggests. The Cardinals continue to push the pace offensively, especially through the air. With injuries at running back forcing Arizona into a pass-heavy approach, they are throwing on 65.4 percent of offensive snaps, the second-highest rate in the league.
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That passing volume matters in this matchup because both defenses rank in the bottom 10 in passing success rate allowed. Atlanta has seen six of its last seven games go over the total, while eight of Arizona’s last ten games have also cleared the number. If the Falcons get Drake London back, that only adds fuel to a game script that already points toward scoring.
Betting Trends for ATL and ARI
- Falcons are 1-5 ATS as a favorite this season.
- Six of Atlanta’s last seven games have gone over the total.
- Cardinals are 1-5 ATS over their last six games.
- Eight of Arizona’s last ten games have gone over the total.
Key Injuries and Notes for ATL and ARI
- Atlanta is hopeful to have Drake London back in the lineup.
- Arizona continues to deal with injuries at running back, pushing the offense toward a pass-heavy identity.
ATS and Total Picks
- ATS Pick: Cardinals +2.5
- Total Pick: Over 47
Final Score Prediction
Falcons 28, Cardinals 27
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