Atlanta Falcons vs. Indianapolis Colts Picks and Prediction for Sunday, November 9th, 2025

A non-conference matchup on Sunday could be a scintillating one in this Falcons vs. Colts prediction. The Atlanta Falcons (3-5, 4-4 ATS, 2-5-1 O/U) meet with the Indianapolis Colts (7-2, 6-3 ATS, 5-4 O/U) in the NFL Berlin Series on Sunday afternoon, and we have you covered with the prediction. The Falcons netted a road win against the Patriots in their previous action. The Colts were dealt a loss by the Steelers last week. These squads last met in 2023 in a game the Falcons won.

Can the Colts rebound after their second defeat with a big win on Sunday? Keep reading for the Falcons vs. Colts prediction. When it comes to college football selections, our NFL Predictions are stellar.

Falcons vs. Colts Matchup

Falcons Dealt Third Straight Defeat

The Atlanta Falcons are a desperate team. They have expectations to be a playoff team and need wins now, as they are well out of a playoff spot. The Falcons have dropped three consecutive games due to the sputtering offense. They dropped meetings against the 49ers and Dolphins to conclude October. Next, Atlanta was dealt a narrow 24-23 road loss against the Patriots last week in a game where the Falcons were 5.5-point dogs. The Falcons have covered the spread in three of their past five games.

Michael Penix Jr. is attempting a ton of passes, about 35-40 per game. The 25-year-old QB has posted 220 or more yards in all but two games and has delivered 1630 passing yards and an 8:3 TD to INT ratio on the season. Bijan Robinson has surpassed 100 yards in two games this season. The 23-year-old running back registered 46 yards last week and has netted 595 rushing yards on the year.

The Falcons have three receivers with more than 350 yards on the season. Drake London is targeted the most and has been a beast, amassing at least 110 yards in three of his past four games. London has 587 receiving yards on the year. Bijan Robinson has been used as a threat out of the backfield with screen passes and stands second in the team with 463 receiving yards.  The Atlanta offense only managed 288 total yards against the Patriots' defense. They are averaging 335 yards per game.

The Falcons' defense has been inconsistent. The numbers look good on paper, but they have given up 24 or more points in five of their past six games. They conceded 331 total yards against New England and are keeping opponents to an average of 282 yards per game. Dee Alford has been sharp in the secondary, deflecting six passes. The pass defense is dominant, ranking 1st, while the rush defense is below average, coming in at 23rd.

Atlanta is averaging 17.9 points on the season, ranking them 28th. The Falcons are conceding an average of 22.3 points, placing them 15th in the NFL.

Colts Streak Ends in Loss vs. Steelers

The Indianapolis Colts are standing in first place in the AFC South, 1.5 games ahead of the Jaguars. The Colts are having an outstanding season. They have only dropped two games. The first defeat was against the Rams. Indianapolis defeated the Cardinals and Chargers in the recent winning streak, but the streak was snapped in a 27-20 road defeat by the Steelers last week. The Colts were marked as three-point favorites in that one. The Colts have covered the spread in three of their past five games.

Daniel Jones is having the best season of his career. The 28-year-old stumbled in the past few seasons with the Giants but has been a different QB with Indianapolis. Jones has posted 260 or more yards on six occasions and has recorded 2404 passing yards and a 14:6 TD to INT ratio on the season. The Indy offense will run more than pass. Jonathan Taylor is having a monster season. The 26-year-old running back has amassed at least 66 yards in all but one game and has piled on 895 rushing yards.

The Indianapolis receiving group is proving to be one of the best. Michael Pittman Jr. has been dominant, bringing in 210 yards in his past two games, and now has 561 receiving yards on the season. Pittman is dealing with a leg injury, but did practice on Thursday and is expected to suit up. Tyler Warren has been one of the best tight ends. He has reported 518 yards. The Indianapolis offense generated 368 total yards in the defeat against the Steelers. They are delivering 383 yards per game.

The Colts' defense was not the issue in the defeat last week. While the defense gave up 27 points against Pittsburgh, it was only on 225 total yards. They are keeping opponents to 331 yards per game. Zaire Franklin has made 50 combined tackles. Safety Cam Bynum leads the team with five deflected passes. The Colts' management made a huge trade earlier this week by acquiring star CB Sauce Gardner to improve the shaky secondary. The pass defense is rated 26th, while the rush defense is among the best, standing fourth. Unfortunately, the defense took a shot with the loss of DT DeForrest Buckner, who as 26 tackles and four sacks.

Indianapolis is averaging 32.2 points on the year, leading the entire NFL. The Colts are holding opponents to an average of only 20.1 points, marking them sixth in the NFL.

Key Injuries and Analysis for Falcons vs. Colts

Falcons

• Starting OG Chris Lindstrom (foot) is questionable.
• Starting CB Mike Hughes (neck) is questionable.
• Starting DE Leonard Floyd (1.5 sacks) is out due to a hamstring injury.

Colts

• Star DT DeForest Buckner (neck) was placed on the IR on Friday. Big loss for the Colts defense, which is top five against the run.

Falcons vs. Colts Pick

Spread Pick for Falcons vs. Colts

• Indianapolis Colts -6.5 (5 units)

The Atlanta Falcons have been shaky. They have dropped three straight games and were not competitive in two of them. This includes a defeat against the Dolphins. The Indianapolis Colts are standing atop the AFC and have won four of their past five games. While the Colts sustained a loss last week, they kept the Pittsburgh offense to 225 total yards.

Furthermore, the Falcons' defense is struggling this month, conceding 24 or more points in three of their past five games. I expect Indianapolis to do big damage on the ground via Jonathan Taylor. He is having a monster season and has led the Colts to a rushing offense that stands seventh. The success should continue against a shaky Falcons’ rush defense that is ranked 23rd in the NFL. Also, the Colts acquired top cornerback Sauce Gardner in a massive trade this week, which enhances the Colts' weak pass defense.

Over/Under Pick for Falcons vs. Colts

• Over 49 (5 units)

I expect plenty of scoring. Atlanta scored 23 points against a good Patriots defense last week and has scored 23 or more points in three of their past five games. The Colts' defense can be solved. They rank at the league average in yards conceded and have squandered 24 or more points in three of their past four games.

In addition, the Falcons' defense has been inconsistent and is up against an Indianapolis offense that has been stellar. They rank 2nd in total yards and lead the entire NFL in points per game. Indianapolis is posting big numbers in just about every game. They have scored 29 or more points in all five of their home games this season. This includes meetings against the Cardinals and a stingy Chargers defense.