Bengals vs. Bills. Picks and Prediction for Sunday, December 7, 2025
Use Code WWWC The Cincinnati Bengals (3-9, 4th in the AFC North) are on the road Sunday, visiting Highmark Stadium in Orchard Park, New York, to play the Buffalo Bills (8-4, 2nd in the AFC East). Cincinnati defeated the Baltimore Ravens 32-14 last Thursday night, snapping a four-game losing streak. Buffalo defeated the Pittsburgh Steelers 26-7 last Sunday and has won four of its last six. Buffalo is second in the AFC East and currently 7th in the AFC playoff picture, one game ahead of the Houston Texans, with only the top seven making the postseason. Make sure to read this in-depth Bengals vs Bills prediction. Ready for action? Check out our free NFL picks for the Cincinnati Bengals at Buffalo Bills prediction and score big!
Cincinnati wins with Burrow back
The Cincinnati Bengals are 16th in scoring, averaging 23.3 points per game, while 32nd or last in points allowed at 31.2 points per game. Cincinnati averages 313.3 yards (22nd) of total offense per game, while the Bengals are 11th in passing yards and 30th in rushing yards per game. Cincinnati's defense allows an average of 410.0 yards (32nd) per game. The Bengals are 31st or next to last in rushing yards allowed and 32nd or last in passing yards allowed.
Cincinnati starting quarterback Joe Burrow has returned from a toe injury, and the Bengals still have a long shot at winning the AFC North, at two games behind the Steelers and Ravens. But they will likely need to win out just to get to eight wins. Burrow has 450 yards passing with four touchdown passes and no interceptions. Chase Brown leads all rushers for Cincinnati with 740 yards and two touchdowns. Ja’Mar Chase is the leading receiver with 971 yards and five touchdown receptions. Tee Higgins (questionable) is second in receiving at 575 yards and has 7 touchdown receptions. Safety Jordan Battle is the leading tackler with 92. Cincinnati's defense has made 17 sacks and intercepted 10 passes.
Key Injuries for Bengals:
- DE Trey Hendrickson is doubtful
- WR Tee Higgins is questionable. Second-leading receiver.
Buffalo has played well on both sides of the line of scrimmage
The Buffalo Bills are fifth in scoring, averaging 28.1 points per game, and 13th in points allowed, at 21.6 points per game. Buffalo is second in total offense, averaging 381.0 yards per game. The Bills are first in rushing and 10th in passing yards per game. Buffalo is 8th in total defense, allowing an average of 304.5 yards per game. The Bills are first in passing yards allowed but 30th in rushing yards allowed.
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Buffalo quarterback Josh Allen has 2,832 yards passing with 19 touchdowns and 10 interceptions. James Cook III is the leading rusher with 1,228 yards and 8 touchdowns, while Allen has rushed for 409 yards and 11 touchdowns. The leading receiver is Khalil Shakir with 569 yards and three touchdown receptions. Dalton Kincaid (questionable) is second with 448 yards and four touchdown receptions. Safety Cole Bishop is the leading tackler with 65. Buffalo’s defense has made 27 sacks and intercepted eight passes.
Key Injuries for Bills:
- DE A.J. Espensa (foot) has 2.5 sacks. Is questionable.
- TE Dalton Kincaid (hamstring/knee) is questionable.
- LB Terrel Bernard (elbow) is out. Has 40 tackles and one INT.
- DE Joey Bosa (hamstring) is out. Has 5 sacks.
- WR Joshua Palmer (knee/ankle) missed Thursday's practice. Is listed as doubtful.
Betting Trends for Bengals vs. Bills:
Bengals are:
- 5-1 ATS last 6 vs. Bills.
Bills are:
- 4-2 ATS last 6 games.
- 4-1 Under last 5 games.
- 5-0 Under last 5 vs. Bengals.
Cincinnati Bengals at Buffalo Bills Pick
Spread Pick for Bengals vs. Bills
- Cincinnati Bengals +5.5 (4 units)
The Buffalo Bills are likely to win at home on Sunday, but Buffalo's defense is not the best, and Cincinnati will play well enough with Joe Burrow back under center to cover the spread on the road. Temperatures are expected to be very cold on Sunday in Buffalo, with a low of 18° forecasted, which could make the offenses more conservative and also create the possibility of turnovers. Snow may come into play with a 40% chance of snow in the forecast, which would help to level the playing field, while also ending drives due to turnovers. Buffalo is one of the weakest against the run, at 30th, and Cincinnati will use Chase Brown to establish a running game in an attempt to keep pressure off Burrow when he drops back to pass. Cincinnati has covered the spread in five of its last six games against Buffalo. The Bills will take advantage of a weak Cincinnati defense against the run, but that will eat up time on the clock, creating fewer possessions, fewer chances to score, and keeping the game closer.
Over/Under Pick for Bengals vs. Bills
- Under 53.5 (4 units)
Frigid cold weather will help keep both offenses from passing the ball as often as usual, which will create more running by both, which will take plenty of time off the clock. The total has finished under in six of Cincinnati's last nine games against a team from the AFC. Buffalo has had the total finish under in four of its last five games and in all of the last five versus Cincinnati.
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