Buffalo Bills at Cleveland Browns, Preview, Odds, Picks and Prediction, Sunday, December 21, 2025
Use Code WWWC It’s an AFC battle between a playoff bound team and a top draft pick franchise on Sunday, Dec. 21. Read our Buffalo Bills vs Cleveland Browns prediction along with our other NFL Picks! The Bills are 10-4 and they are one game behind the Patriots for the top spot in the AFC East. Buffalo has won six of their last eight games coming into this matchup. The Browns have had a disaster of a season with a 3-11 record, but Cleveland is looking to have Myles Garrett break the NFL record for sacks in a season in this game. These two teams will meet with kick-off set for 1 P.M. EST.
Buffalo still contending for AFC East title
Buffalo is 10-4 overall this season. The Bills are in second place in the AFC East as they trail the Patriots, who are 11-3. The Bills are 4-3 when playing on the road this year. They are currently the No. 6 seed in the AFC as they look to reach the playoffs once again. The Bills have won three straight games while they have also won six of their last eight outings.
In their last game, the Bills defeated New England 35-31 in a key divisional matchup on Sunday, Dec. 14. The Patriots jumped ahead 21-0 midway through the second quarter, before taking a 24-7 lead at halftime. The Bills took the lead as they scored 21 straight points along with a James Cook rushing touchdown late in the fourth quarter to seal the win. Josh Allen threw for 193 yards on 19-for-28 passing and three touchdowns. Cook added 107 rushing yards and two scores.
Allen leads the offense with 3,276 passing yards and 535 rushing yards. He has tossed 25 touchdowns and rushed for a team-high 12 scorers, but he has thrown 10 interceptions. Cook is rushing for a team-high 1,415 yards while Khalil Skahkir has a team-high 650 receiving yards.
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The Bills are averaging 29.4 points per game, which ranks fourth-best in the league. They have the best rushing offense, averaging 158.5 rushing yards per game. Buffalo is also averaging 222.7 passing yards per game, which ranks 13th.
On defense, Buffalo is allowing 23.1 points per game, which ranks 17th in the league. They are the second-best pass defense giving up 169.5 pass yards per game. The Bills are the third-worst rush defense giving up 143.1 yards per game.
Buffalo is 7-7 against the spread this season. The Bills are 4-3 against the spread when playing on the road. They are 0-4 against the spread when favored by 8 points or more. The total is 7-7 when the Bills have played this season. The under is 5-2 when they have played on the road. The over is 5-3 when Buffalo has been favored by 6 points or more.
Injury report
- DT Jordan Phillips (Ankle), out
- K Matt Prater (Quad), out
- OT Chase Lundt (Knee), out
- WR Mecole Hardman (Calf), questionable
- DB Cam Lewis (Hamstring), questionable
Myles Garrett looks to break NFL sack record
Cleveland is 3-11 overall this season. The Browns are in last place in the AFC North. The Browns have the second-worst record in the NFL as Las Vegas, Tennessee and the Giants all have just two wins. The Browns have lost three straight games. They have also six of their last seven games.
In their last game, the Browns lost to the Bears 31-3 on the road on Sunday, Dec. 14. The Browns struggled as they accumulated just 192 total yards. They turned the ball over three times in the defeat. Shedeur Sanders threw for 177 yards on 18-for-35 passing and three picks. The offense simply couldn’t do anything against a playoff bound Chicago team.
Sanders has thrown for 946 yards this year and has completed 52.2% of his throws. He has thrown five touchdowns and six interceptions on the year. Quinshon Judkins leads the team with 805 yards and seven touchdowns. Tight end Harold Fannin has hauled-in a team-high 667 yards.
On defense, Myles Garrett has been dominant this season. He has 21.5 sacks on the season, which is one sack away from tying the all-time record. If Garrett were able to secure more than one sack, he will own the NFL record.
Cleveland is averaging 16.1 points per game, which ranks third-worst. They are throwing for 171.9 passing yards per game, which ranks third-worst. The Browns are also the fourth-worst rush offense, averaging 92.4 yards per game.
On defense, Cleveland is allowing 23.7 points per game, which ranks 20th. They are the best pass defense in the NFL allowing 169 yards per game. The Browns are surrendering 110.1 rush yards per game, placing them 14th.
Cleveland is 5-9 against the spread this season. The Browns are 4-3 against the spread when they have played at home. Cleveland is 0-2 against the spread when they have been underdogs by 8 points or more. The Browns are 1-3 against the spread since Sanders has started at quarterback. The total is 7-7 when the Browns have played this year. The over is 4-3 when they have played at home. The under is 3-2 when the Browns have been underdogs by 7 points or more.
Injury report
- OT Jack Conklin (Concussion), out
- CB Denzel Ward (Calf), out
- QB Deshaun Watson (Achilles), out
- LB Sam Kamara (Elbow), questionable
Buffalo Bills vs Cleveland Browns Picks
Bills vs Browns Spread Pick
- Buffalo Bills -10 (5 units)
The Browns have played their best at home this season, but they have truly struggled recently against playoff opponents. Last week was a disaster for them as they were dominated by the Bears. Buffalo’s defense needs to get off to a quick start and the Browns will be done and dusted. The rookie heavy offense for Cleveland cannot move the ball in chunk plays and they can’t score the ball on a consistent basis. Buffalo’s offense has been trending in the right direction as it looked really good in the second-half of last week’s win over New England. If the Bills can move the ball well, Buffalo will only need at least 17 points to come away with an easy win. But, Cleveland has turned the ball over multiple times in the past few weeks, wchih will give Buffalo great field position and consistent scoring opportunities.
Take the Bills to cover.
Bills vs Browns Over/Under Pick
- Under 41 (5 units)
The Browns defense will give it their all to keep the team in the game. The Bills haven’t been their best on the road while the Browns defense has been on fire inside their home building. This has the makings of a low scoring game as Cleveland’s offense has struggled for big points against any team in any location. The under is 3-2 when the Browns have been underdogs by 7 points or more. The under is 5-2 when Buffalo has played on the road.
Take the under on Sunday.
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