Carolina Panthers vs. San Francisco 49ers, Odds, Preview, Picks and Prediction for Monday, November 24, 2025
Week 12 of the 2025 NFL season comes to a close with an NFC matchup when the Carolina Panthers battle the San Francisco 49ers on Monday Night Football in the Golden State, and we have you covered with our Panthers vs. 49ers prediction. Carolina comes in off a 30-27 overtime road win over Atlanta last Sunday in their previous contest, winning outright as a 3.5-point underdog. San Francisco rolled to a 41-22 win over Arizona on the road in their previous contest last Sunday, covering the line as a 3.5-point favorite. In the all-time regular season series between the teams, the Panthers own a 13-10 advantage but the 49ers have won the last two meetings, including a 37-15 road win in the most recent matchup on October 9, 2022. Read more about this 49ers vs. Panthers prediction! Don’t get sacked this football season! Try our NFL Picks!
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Panthers Trying to Hang in Playoff Picture
Carolina won for the fifth time in seven games as they swept Atlanta on the road with an overtime win last week. The Panthers improved to 6-5 overall and stood second in the NFC South, half a game behind the Buccaneers for the top spot. They stood one game behind the 49ers for the final wild card spot in the NFC. Against Atlanta, Carolina led 7-0 early before giving up 21 unanswered points to trail 21-7. The Panthers trimmed the margin to 21-10 at the half, 21-19 after three quarters and led 27-24 with just over a minute to play only to allow the Falcons to tie the score in the closing seconds of regulation. In overtime, Carolina forced a three-and-out before driving 60 yards to set up Ryan Fitzgerald’s game-winning 28-yard field goal. The Panthers owned a 486-348 edge in total offense, owned a 37:07 to 27:43 margin in time of possession and forced the game’s lone turnover to offset giving up 23 first downs while recording 22.
For the season, the Panthers enter week 12 27th in the league in passing offense with an average of 187.2 yards per game through the air and 9th in rushing offense by grinding out 127.1 yards per contest. Carolina is 28th in the league in scoring offense as they average 18.8 points per game, while they are 13th in the league in scoring defense by allowing 22.6 points per contest. Bryce Young is 197 of 314 for 1,962 yards with 14 touchdowns and seven interceptions while contributing 83 yards and a score on the ground. Andy Dalton has completed 25 of 37 passes for 293 yards with one touchdown and one interception. Rico Dowdle leads the ground game with 168 carries for 833 yards and five scores. Chuba Hubbard (91 carries, 334 yards, TD) is next in line in that department. Rookie Tetairoa McMillan leads the team with 54 receptions for 748 yards and four scores. Xavier Legette (24 receptions, 264 yards, three TD), Dowdle (23 catches, 197 yards, TD), along with tight ends Tommy Tremble (19 grabs, 184 yards, TD) and Ja’Tavion Sanders (24 catches, 170 yards) have been valuable options as well. Ryan Fitzgerald is 16 of 19 on extra point attempts and 17 of 20 on field goal tries with a long of 57 this season.
Injury Report for Panthers:
- C Cade Mays (ankle) is out
- LB Trevin Wallace (shoulder) is out. Has 33 tackles and two sacks.
- LB Christian Rozeboom (hamstring) is out. Has 43 tackles.
San Francisco in Thick of NFC West Race
San Francisco has alternated wins and losses in their last eight games after downing Arizona in their previous contest on the road last Sunday. The 49ers improved to 7-4 on the year and are third in the NFC West, 1.5 games behind the Rams for the top spot. They own the final wild card spot in the NFC playoff picture. Against Arizona, San Francisco jumped in front 13-0 just over five minutes into the game and never let the Cardinals get even the rest of the way. The 49ers led 25-10 at the half and 35-10 after three quarters en route to the win. San Francisco was outgained 488-281, lost time of possession by a 34:15 to 25:45 margin and saw each team pick up 24 first downs in the game. The 49ers forced three turnovers while committing none and had a kick return on the opening kickoff that set them up at the Arizona one-yard line. News broke on Friday that the team and injured receiver Brandon Aiyuk could be nearing a breakup after the team voided his guaranteed money for 2026.
On the year, the 49ers are 2nd in the league in passing as they average 254.5 yards per game through the air. San Francisco is 27th in the league in rushing offense as they pile up 94.8 yards per game on the ground this season. The 49ers are 15th in the league in scoring offense as they put up an average of 23.7 points per game. San Francisco is 14th in the league in scoring defense by allowing an average of 22.9 points per contest. Brock Purdy is 67 of 99 passing for 786 yards with seven touchdowns and four interceptions while getting sacked three times. He adds 23 yards on the ground. Mac Jones (201 of 289, 2,151 yards, 13 TD, six INT, 61 rush yards) has stepped up with Purdy missing time. Christian McCaffrey leads the ground game with 193 carries for 707 yards and six scores. Brian Robinson Jr. (57 carries, 262 yards, two TD) is the second back in the system. McCaffrey leads the team with 74 receptions for 762 yards and five scores this season. Jauan Jennings (32 catches, 378 yards, three TD), tight end Jake Tonges (26 grabs, 226 yards, three TD), George Kittle (27 catches, 251 yards, five TD), Kendrick Bourne (31 catches, 482 yards) and Ricky Pearsall (21 receptions, 327 yards) are all over 200 receiving yards on the season. Jake Moody was two of two on extra point attempts and one of three on field goal attempts with a long of 32 this season before being cut after the opener. Eddy Piniero is 18 of 22 on extra points and 22 of 22 on field goals with a long of 59 on the year.
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Injury Report for 49ers
- LB Tatum Bethune (ankle) is out. Has 26 tackles.
- PK Eddy Pineiro (hamstring) is out.
Panthers vs. 49ers Pick
Spread Pick for Panthers vs. 49ers
- 49ers -7 (4 units)
Carolina has won five of seven and is nipping at the heels of the Buccaneers in the NFC South race. The Panthers are 3-3 on the road this season and have won three straight away from Charlotte, though only the win over the Packers moved the needle much. San Francisco is at home here, where they are 2-2 on the year compared to 5-2 on the road, so they have plenty of home cooking down the stretch. The 49ers got Purdy back last week and he didn’t miss a beat as they piled up 41 points in the win over Arizona. McCaffrey is an explosive dual threat out of the backfield and the 49ers are capable of doing damage offensively. Look for San Francisco to come up with the victory in this contest as they take care of business at home.
Over/Under Pick for Panthers vs. 49ers
- Over 49.5 (4 units)
Carolina enters this game having gone over the mark in six of their 11 games on the season entering this game. The Panthers have split their six games in relation to the total on the road this season. Carolina is coming off an over in their overtime win over Atlanta on the road last week. San Francisco has seen the over post a 7-3-1 mark on the year entering this game. The 49ers have split their four games in relation to the total at home and has seen the over post a 6-1-1 mark in their last eight games, including three straight overs entering this game. Three of the last four meetings, including the last two, have gone over the total. Look for plenty of points here as the game winds up over the total.
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