Denver Broncos vs Indianapolis Colts Picks and Prediction for Sunday, September 14, 2025
Use Code WWWC On Sunday, the Denver Broncos (1-0) will visit Indianapolis, Indiana, and Lucas Oil Stadium to play the Indianapolis Colts (1-0). Denver opened its regular season with a 20-12 victory over the Tennessee Titans at home. Indianapolis opened its regular season with a resounding 33-8 victory over the Miami Dolphins. Denver will play without DT Malcolm Roach as well as four others, while five are questionable. Indianapolis will play without eight players, including LB Jaylon Carlies. Four others are questionable, including cornerbacks Charvarius Ward and backup Jaylon Jones, which could leave the Colts suspect in the secondary. Make sure to read this in-depth Denver Broncos vs Indianapolis Colts prediction. Dominate Sunday with our NFL picks for the Denver Broncos vs. Indianapolis Colts prediction—your winning playbook starts here.
Denver is just average on offense, but one of the best on defense
The Denver Broncos scored 20 points in their opening game and allowed 12 points. Denver's offense was led by its running game with 151 yards while its passing attack generated 166 yards, which were 7th and 21st, respectively. The defense gave up next to nothing, allowing 71 yards rushing, which was the 8th best, and 62 yards passing, which was the fewest allowed in Week 1.
Denver quarterback Bo Nix has 176 yards passing with one touchdown and a pair of interceptions. Nix was sacked just once. RJ Harvey is Denver's leading rusher with 70 yards, and J.K. Dobbins is second with 63 yards and has scored one touchdown. Courtland Sutton leads all Denver receivers with six receptions for 61 yards and one touchdown.
Denver's defense is led in tackles by S Talanoa Hufanga with 10. Denver made 6.0 quarterback sacks but did not intercept a pass in the opening game of the season. Patrick Surtain II, last year's AP Defensive Player of the Year, leads one of the best pass defenses in the NFL, which held rookie Cam Ward and the Titans to just 133 total yards with seven first downs. Linebacker Dre Greenlaw (quad) and DL Malcolm Ranch (calf) are out for this game.
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Indianapolis is playing well on both sides of the line scrimmage
The Indianapolis Colts scored 33 points in their season opener in their win over the Dolphins. Indianapolis used a strong running game with 156 yards while passing for 262, which were six and eight, respectively. The Indianapolis defense allowed 78 rushing yards and the 4th fewest yards through the air with 133.
Former New York Giants quarterback Daniel Jones is the signal caller for Indianapolis, and in the opening game of the season had 272 yards passing with one touchdown. Jonathan Taylor has 71 yards on 18 carries for an average of 3.9 yards per carry, while Michael Pittman Jr. caught six passes for 80 yards and one touchdown reception. The Indianapolis defense was led in tackles by cornerback Charvarius Ward with six. Ward is not expected to play in this game due to a concussion and the Colts will also be without backup corner Jaylon Jones. The Indianapolis defense recorded three quarterback sacks in the opening game and intercepted two passes.
Denver Broncos vs. Indianapolis Colts Pick
Spread Pick for Denver Broncos vs. Indianapolis Colts
- Denver Broncos -2.5 (4 units)
Denver’s defense looked strong in the opening game of the season, allowing just 12 points, while giving up just 71 yards rushing and 62 yards passing. Denver did not force any turnovers, yet was able to win by eight points. Denver, behind quarterback Bo Nix, will take advantage of a banged-up Indianapolis secondary, which currently lists its starting and backup cornerbacks as questionable. Charvarius Ward, who leads Indianapolis in tackles with six, is one of the starting cornerbacks and is in concussion protocol, while backup Jaylon Jones did not take part in practice on Wednesday. Nix should bounce back from a rocky start and take advantage of backups at cornerback. Denver's solid pass rush, which produced six quarterback sacks in Week 1, will pressure Colts’ QB Daniel Jones from the start.
Over/Under Pick for Denver Broncos vs. Indianapolis Colts
- Under (5 units)
Denver's opening game of the season had a combined 32 points scored, which easily finished under the closing line of 42.5 points. Indianapolis’ opening game had a combined 41 points scored and finished under the closing line of 47 points. Both Denver and Indianapolis appear to have strong defenses, which will dictate the play and flow of the game on Sunday.
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