Denver Broncos vs. Los Angeles Chargers, Picks and Prediction, Sunday, September 21, 2025
Use Code WWWC Denver (1-1) will be trying to pick up their first road win of the season when they visit SoFi Stadium on Sunday afternoon to face Los Angeles (2-0) in an AFC West showdown at 4:05 PM. ET. Read on to find out which team picks up the win in this Broncos vs. Chargers prediction. Don’t get sacked this football season! Try our NFL Picks!
The Broncos are coming off a 29-28 loss to Indianapolis as one-point favorites. The Chargers are coming off a 20-9 win over Las Vegas as 3.5-point favorites.
Denver and Los Angeles split their last 10 meetings.
Denver Trying To Bounce Back From Loss
The Broncos followed up their season-opening win over Tennessee with a one-point loss to the Colts in their last game. They will try to bounce back from the loss and pick up their first road win of the season when they play on Sunday. A missed field goal at the end of the game seemed to give the Broncos the win, but Denver was called for a leverage penalty and Spencer Shrader nailed the kick to give the Colts the victory. Denver kicker Will Lutz also missed a 42-yard field goal with 3:19 left in the game to allow Indy a chance to nail the game-winning kick.
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Denver is averaging 24 points per game through two games. They are throwing for 186 yards and rushing for 134.5 yards per game.
Bo Nix has completed 67 percent of his passes for 382 yards, four touchdowns, and three interceptions. J.K. Dibbins leads the team with 30 carries for 139 yards and two touchdowns, while Troy Franklin leads the team with 12 catches for 133 yards and one touchdown.
Denver is giving up 20.5 points per game through two games. They are giving up 184 passing yards and 119 rushing yards per game. TE Evan Ingram (back), LB Dre Greenlaw (quad) and LB Justin Strnad (foot) missed practice on Wednesday and are questionable.
Los Angeles Going For Third Consecutive Win
The Chargers are off to a good start after picking up wins over the AFC West rivals, the Chiefs and Raiders, to start the season. They will try to keep the momentum going and pick up their third straight win when they play on Sunday. On Monday night, the Chargers were able to beat Las Vegas on the road. LB Daiayn Henley had a monster game with 10 tackles, a sack and one of their three interceptions against Geno Smith.
Los Angeles is averaging 23.5 points per game through two games. They are throwing for 270 yards and rushing for 85.5 yards per game.
Justin Herbert has completed 72 percent of his passes for 560 yards and five touchdowns. Omarion Hampton leads the team with 23 carries for 72 yards, while Quentin Johnston leads the team with eight catches for 150 yards and three touchdowns.
Los Angeles is giving up just 15 points per game through two games. They are giving up 199.5 passing yards and 83 rushing yards per game.
Injury Report: Khalil Mack, who left their last game with an elbow injury, was put on the IR and is expected to miss the next four games at a minimum.
Denver vs. Los Angeles Pick
Point Spread Pick for Denver vs. Los Angeles
- Los Angeles Chargers -3 (4 Units)
The Chargers have won two straight games, while the Broncos split their first two games. Los Angeles has the edge here because they’ve been able to throw the ball effectively despite playing two good defenses, and will be able to move the ball through the air against a Denver defense that gave up more than 300 passing yards to Daniel Jones and the Colts in their last game.
Denver won't be as successful offensively because it’s been one-dimensional so far, with the 10th-best ground game in the league and one of the worst passing games. The Chargers are great against the run, and they’re also holding opponents under 200 passing yards per game, so expect them to keep Denver’s offense in check. Nix has also been disappointing thus far and he's facing a very difficult defense on Sunday that just picked Geno Smith off three times. Take Los Angeles to cover the spread.
Over/Under Pick for Denver vs. Los Angeles
- Under 46 (4 Units)
The Broncos played under the total in three of their last four games. Denver averages 24 points per game. They throw the ball 56 percent of the time, and they have the 25th-best passing attack in the league. They are facing a defense that is giving up less than 200 passing yards per game and has held their first two opponents to 15 points per game. The Chargers average 23.5 points per game. They throw the ball 56 percent of the time, and they have the third-best passing attack in the league. They are facing a team that is ninth against the pass and is giving up 20.5 points per game. Don’t expect these teams to score enough points to push the score over the total.
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