Detroit Lions vs. Kansas City Chiefs Picks and Prediction for Sunday, October 12, 2025
Use Code WWWC Detroit Lions (4-1) vs. Kansas City Chiefs (2-3)
Week 6 of the 2025 NFL season brings Sunday Night Football from GEHA Field at Arrowhead Stadium in Kansas City, MO, so we have prepared the Lions vs. Chiefs prediction and the latest team stats and news to get you covered.
Detroit and Kansas City lock horns for the first time since September 7, 2023, when the Lions edged out the Chiefs 21-20 as 4-point road underdogs. The Lions are 2.5-point road dogs for the upcoming clash, while the total sits at 52.5 points.
Let’s take a closer look at this Lions vs. Chiefs prediction, one of our NFL picks for Week 6. Sunday Night Football kicks off at 8:20 PM ET.
The Lions aim for their fifth straight victory
The Detroit Lions (4-1; 4-1 ATS; 3-2 O/U) started their 2025 campaign with a 27-13 road loss against the Green Bay Packers. Since then, the Lions have been unstoppable, tallying four consecutive wins over the Chicago Bears 52-21, the Baltimore Ravens 38-30, the Cleveland Browns 34-10, and the Cincinnati Bengals 37-24.
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Last week, the Lions cruised past the Bengals, covering a 10-point spread at Paycor Stadium in Cincinnati. Detroit picked off Jake Browning three times and outgained Cincinnati 365-322 in total yards. Jared Goff threw for 258 yards and three touchdowns, while Amon-Ra St. Brown had eight catches for 100 yards.
David Montgomery had a TD pass in Week 5, too. Interestingly, Montgomery played quarterback at Cincinnati Mt. Healthy High School. He finished the game with 18 carries for 65 yards and a touchdown.
“We wanted to get Montgomery going because I knew this was going to be special for him,” Detroit head coach Dan Campbell said. “He started to break it open in the second half and started wearing down on the defense.”
The Lions lead the NFL in scoring offense with 34.8 points per game. Goff has thrown for 1,187 yards, 12 touchdowns, and two interceptions so far this season, while Montgomery and Jahmyr Gibbs have combined for 788 yards from scrimmage and nine touchdowns.
St. Brown leads the receiving corps with 35 catches for 407 yards and six touchdowns. He missed Wednesday’s practice due to a wrist injury and is questionable for Week 6. Safety Kerby Joseph (knee), wideout Kalif Raymond (neck), cornerback Terrion Arnold (shoulder), and left tackle Taylor Decker (shoulder) are all questionable, too.
The Chiefs are in trouble
The Kansas City Chiefs (2-3; 2-3 ATS; 3-2 O/U) started the season with consecutive defeats against the Los Angeles Chargers 27-21 and the Philadelphia Eagles 20-17. After that, the Chiefs strung together a couple of wins over the New York Giants 22-9 and the Baltimore Ravens 37-20.
Last Monday, the Chiefs returned to the losing track. They suffered a 31-28 defeat at the Jacksonville Jaguars, blowing a 14-point lead. The Chiefs outgained Jacksonville 476-319 in total yards, but they committed a whopping 13 penalties for 109 yards.
Kareem Hunt led the way for the Chiefs in Week 5, posting seven carries for 49 yards and two touchdowns. Patrick Mahomes carried the pigskin six times for 60 yards while throwing for 318 yards, a touchdown, and an interception, and his turnover led to Devin Lloyd’s 99-yard pick-six.
“We had 13 penalties, to their 4. Whether I agree with them or don’t agree with them, it doesn’t matter. They called them. So, you have that many penalties, you give up field position, you can outstat them to death, but that doesn’t matter. It’s the score that matters,” Kansas City head coach Andy Reid said.
The Chiefs score 25.0 points per game (tied for 12th in the NFL). Mahomes has tossed for 1,257 yards, eight touchdowns, and two interceptions, while Tyquan Thornton has amassed 272 receiving yards and three touchdowns.
Kansas City desperately needs more from its backfield. Mahomes leads the team in rushing yards with 190. Hunt has accounted for 164 yards and three touchdowns on 43 carries, while Isiah Pacheco has recorded 39 totes for 163 yards.
Lions vs. Chiefs Pick
Spread Pick for Lions vs. Chiefs
- Detroit Lions +2.5 (5 units)
The Chiefs might miss cornerback Kristian Fulton (ankle), wideout Xavier Worthy (ankle/shoulder), and defensive tackle Omarr Norman-Lott (shoulder), so the Lions certainly have more injury worries than Kansas City. Anyway, the Lions have enough weapons to contain the Chiefs on both sides of the ball and keep it close down the stretch.
Amon-Ra St. Brown has only missed two games throughout his four-plus years in the NFL, so I expect him to suit up. Should Taylor Decker take the field, the Lions will be poised for another strong offensive performance.
Detroit is arguably one of the toughest teams at the line of scrimmage. The Lions’ defense is not an elite one, but their offense is good enough to hurt the Chiefs and help the team cover the spread. Detroit eyes its fifth SU and ATS victory in a row.
Over/Under Pick for Lions vs. Chiefs
- Over 52.5 (5 units)
The Chiefs hope that Xavier Worthy will be able to play. His presence is essential for the Chiefs’ offense, as Worthy is a proper deep threat. Of course, the Chiefs will have to get things going on the ground if they want to satisfy the odds in this matchup. The Lions allow 92.2 rushing yards per game (7th in the NFL) and 4.0 yards per carry (tied for 9th).
Kansas City has struggled against the rush, yielding 123.4 yards per game (21st) and 4.8 yards per carry (tied for 26th). I expect the Lions to extend their strong run of form on the offensive side of the ball, so give me the over on the total. These two defensive units have struggled in the red zone thus far, and the Lions’ third-down defense is far from ideal.
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