Indianapolis Colts vs Los Angeles Rams Picks and Prediction for Sunday, September 28, 2025
Use Code WWWC On Sunday, the Indianapolis Colts (3-0, 1st AFC South) pay a visit to Inglewood, California, and SoFi Stadium to play the Los Angeles Rams (2-1, T-2nd NFC West). Indianapolis defeated the Tennessee Titans 41-20 last Sunday after defeating Miami to open the season, followed by a victory over Denver. The Colts lead the AFC South. Los Angeles lost to the Philadelphia Eagles 33-26 last Sunday, snapping a two-game winning streak after opening the season with victories over Houston and Tennessee. Indianapolis has several players out and several questionable. The most notable is WR Alec Pierce, who is expected to be put into concussion protocol and likely not to play against the Rams. Los Angeles does not have any notable players who are expected to miss. In all, LA has just two players out and two players questionable. Make sure to read this in-depth Indianapolis Colts vs Los Angeles Rams prediction. Dominate Sunday with our NFL picks for the Indianapolis Colts at the Los Angeles Rams prediction—your winning playbook starts here.
Indianapolis is performing well on both sides of the line of scrimmage
The Indianapolis Colts are second in scoring, averaging 34.3 points per game, third in rushing, averaging 153.3 points per game, and fourth in passing, averaging 265.3 points per game. The Colts allow an average of 18.7 points per game, which is 9th. Indianapolis gives up 272.3 yards per game, which is 7th, while allowing an average of 94.0 yards rushing and 178.3 yards per game passing.
Indianapolis quarterback Daniel Jones has 816 yards passing with three touchdowns. Jones has been sacked just twice in three games. Running back Jonathan Taylor leads Indianapolis and the NFL in rushing with 338 yards, averaging 5.6 yards per carry. Taylor has scored three touchdowns on the ground and one through the air. TE Tyler Warren leads the Colts in receiving with 193 yards, averaging 13.8 yards per reception. Michael Pittman Jr has two touchdown receptions. Safety Nick Cross leads in tackles with 20, and end Tyquan Lewis is the leader in sacks with 2.0. Indianapolis has made seven sacks and intercepted four passes
Los Angeles is getting it done on both sides of the ball
The Los Angeles Rams score an average of 24.3 points per game, which is 11th. The Rams average 127.0 yards rushing, which is 9th, and 236.7 yards passing per game, which is 10th. The Rams average 363.7 yards of total offense per game, which is fifth. The Los Angeles defense allows an average of 20.3 points per game, which is 10th. The Rams give up 103.0 yards rushing and 165.3 yards passing for 268.3 yards per game, which is fifth.
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Los Angeles quarterback Matthew Stafford has 739 yards passing with five touchdowns and two interceptions. Stafford has been sacked five times. Kyren Williams leads all rushers for Los Angeles with 226 yards and one touchdown, averaging 4.1 yards per carry. He had a season-best 94 yards against the Eagles on Sunday, as the Rams rushed for 160 yards in that contest. WR Puka Nacua has caught 29 passes for 333 yards, averaging 11.5 yards per reception, but has not yet caught a touchdown pass. Safety Kam Curl leads Los Angeles with 26 tackles. Linebacker Byron Young is the leader in quarterback sacks with 4.0. As a team, Los Angeles has made 12 quarterback sacks and intercepted one pass.
Indianapolis Colts vs. Los Angeles Rams Pick
Spread Pick for Colts vs. Rams
- Los Angeles Rams -3.5 (5 units)
Indianapolis and Los Angeles are both playing well to start the season, but with Los Angeles playing at home and the experience of quarterback Matthew Stafford, the advantage goes to the Rams. Los Angeles is holding opponents to just 268.3 yards of offense per game, has 12 quarterback sacks, and allows 103.0 yards per game on the ground, which will contain the strong running attack of Indianapolis, led by Jonathan Taylor. On offense, the Rams are scoring an average of 24.3 points per game and are fifth in total offense at 363.7 yards per game. Despite losing to Philadelphia last week, Los Angeles was in control for much of the game, leading by as many as 19 points in the third quarter. The Colts will try to establish a running game with Taylor, but look for the Rams to quash that and force Daniel Jones to beat them through the air, which will not happen.
Over/Under Pick for Colts vs. Rams
- Over 50.0 (4 units)
The total has been over in each of Indy’s last two games and each of LA’s last two games. The Colts are third in scoring, and LA is 11th. The offenses will score enough, while the defenses will create a few turnovers and make shorter fields for their respective offenses, which will make for more scoring opportunities. Daniel Jones has found a way as a passer and runner to lift the Colts early on. However, injuries are starting to catch up in the secondary for the Colts and Stafford should take advantage of Kenny Moore II being out.
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