Jaguars vs. Cardinals, Odds, Preview, Picks and Prediction, Sunday, November 23, 2025
The Jacksonville Jaguars will face the Arizona Cardinals on Sunday at State Farm Stadium in Week 12 NFL action, pitting a Jags team that's won two of its last three against a Cards squad that's 1-4 at home. We have you ready to go with our Jaguars vs. Cardinals prediction, preview, and picks.
Kickoff from Phoenix is at 4:05 p.m. ET. The Jaguars are three-point spread favorites, and the game total is 47.5 points scored.
This is the first time Jacksonville and Arizona have played since 2021, when the Cardinals beat the Jaguars 31-19 in Florida. Arizona has won the last four matchups straight-up and covered the spread in each game. The over was 3-1. If you want the Jaguars vs. Cardinals prediction, read on and check out our NFL Picks to beat the sportsbooks!
Sign Up for Winners and Whiners News Alerts, Get Free Picks and Discounts
Subscribe Now
Jaguars made a statement last weekend
Jacksonville (6-4 SU, 5-4-1 ATS, and 5-5 O/U) beat the LA Chargers 35-6 last Sunday, covering the spread as three-point underdogs.
The Jaguars bounced back from their loss to Houston with a dominant performance, scoring a touchdown in each quarter and converting five of their six red zone trips. Los Angeles never found the end zone and didn't score after halftime, managing just 135 total yards. Jacksonville dominated the time of possession by over 15 minutes, as Los Angeles was a combined 4-for-15 on third and fourth down.
“We were (ticked) off at the finish last week," coach Liam Coen said. "We play better (ticked) off. We’ve talked about edge for a long time now. When we have an edge and we play as a team, and it’s about the team all the time, good things happen typically for us. I am proud of the response, for sure.”
QB Trevor Lawrence has completed 59.8 percent of his passes for 2,151 yards with 11 touchdowns and eight interceptions. He averages 6.4 yards per pass and 215.1 yards per game. The Clemson product's top receiving target is WR Brian Thomas Jr. (30 receptions for 420 yards and one TD), and RB Travis Etienne Jr. (154 carries for 729 yards and five TDs) leads the Jags' run game.
Jacksonville scores 24.0 points per game (14th) and averages 326.9 total yards (19th), including 199.4 passing yards (21st) and 127.5 rushing yards (8th). The Jaguars' defense allows 22.6 points (12th) and 323.6 total yards (14th) per game, including 236.9 passing yards (26th) and 86.7 rushing yards (2nd).
Jacksonville Jaguars Football Injury Report:
- WR Brian Thomas Jr., DE Travon Walker, RT Anton Harrison, and TE Hunter Long are out.
- Starting RB Travis Etienne Jr. and his backup, Bhayshul Tuten, are both expected to play. Both were limited in practice earlier this week, but neither had injury designations on Friday. TE Brenton Strange, who has missed the last five games, could also make his return on Sunday.
- Starting CB Jourdan Lewis and backup CB Jarrian Jones are questionable. Both were limited in practice this week.
Cardinals must put up a fight earlier in games
Arizona (3-7 SU, 5-5 ATS, and 6-4 O/U) lost 41-22 to San Francisco last weekend, failing to cover the spread as 3.5-point dogs. The Cardinals have dropped seven of their last eight games.
Seattle and SF have beaten down Arizona the last two weeks, as the Redbirds allowed 40-plus points to both divisional rivals. Interestingly, the Cards outgained the 49ers by over 200 total yards, but the home team coughed up the football three times and was undisciplined (17 penalties for 130 yards). San Francisco scored 25 first-half points and never looked back, as Arizona allowed two touchdowns in the first six minutes in consecutive games, becoming the first NFL team to do so since at least 2000.
“I am a defensive head coach, and it's not acceptable,” Cardinals coach Jonathan Gannon said. “You can't win when you give up that many points, and it really doesn't matter how you get there. You've got to stand up, play better, and keep points off the board.”
QB Jacoby Brissett has started five games in relief of Kyler Murray, who is on the IR with a foot sprain. Brissett has completed 66.7 percent of his passes for 1,570 yards with 10 touchdowns and three interceptions. He averages 7.4 yards per pass and 224.4 yards per game. His top receiving target is TE Trey McBride (71 receptions for 718 yards and seven TDs), and RB Emari Demercado (31 carries for 241 yards) leads the Cards' run game.
Arizona scores 22.4 points per game (19th) and averages 333.5 total yards (14th), including 227.8 passing yards (12th) and 105.7 rushing yards (24th). The Cardinals' defense allows 25.6 points (25th) and 333.6 total yards (21st) per game, including 221.4 passing yards (20th) and 112.2 rushing yards (16th).
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Arizona Cardinals Football Injury Report:
- Leading rusher Emari Demercado, WR Marvin Harrison Jr. (second-leading receiver), safety Dadrion Taylor-Demerson (36 tackles and two INTs), and LB Baron Browning (two sacks) are out.
- OT Kelvin Beachum, OG Will Hernandez, CB Will Johnson, DE Darius Robinson, and CB Garrett Williams are questionable to play against the Jaguars.
Jaguars vs. Cardinals Pick and Preview
Spread Pick for Jaguars vs. Cardinals
- Jacksonville -3 (4 Units)
I lean towards the Jags' side, but this game could be close. They are 2-0-1 ATS as favorites this season. Arizona will move the football through the air, but it lacks a complementary run game and has been turnover-prone recently (five turnovers in the last two games). Brissett has played well overall, but there's a little too much pressure on him for my liking, especially against a Jacksonville defense that's coming off a dominant performance. The Jags have done an excellent job at capitalizing on opponent miscues this season, as well. I anticipate a run-heavy game plan by the visitors, as Arizona has been too soft against the run, as Christian McCaffrey averaged over six yards per carry last week, and Seattle rushed for 198 yards the previous game.
Jacksonville has momentum and is still fighting for a playoff spot. It will play that way on Sunday, covering the small spread.
Over/Under Pick for Jags vs. Cardinals
- Over 47.5 (5 Units)
Betting Trends: The over is 5-1 in Arizona’s last six, and it’s 4-0 in Jacksonville’s road games this season.
I like Jacksonville ATS, but I lean towards the over as my preferred pick in this matchup.
The Jaguars will run the football effectively with Etienne and Tuten expected to play, which will open up the play-action pass for Lawrence. He won't have Thomas Jr. again, but Jakobi Meyers was a reliable outlet for him last week (five catches on six targets for 64 yards), and Strange (20 receptions for 204 yards) could return from a five-game absence. The visitors will have their opportunities at the end zone against a Cardinals defense that allows 3.7 red zone scoring attempts per game, fourth-most in the NFL.
I'm also confident the home team will let Brissett air it out against a porous Jaguars secondary. Only two teams are throwing more than the Cardinals, and their run game has been so inefficient that they won't likely give it much thought. Jacksonville's weak pass defense will allow Arizona to consistently pick up third downs (Cards rank 5th in third down conversion rate) and put points on the scoreboard (Jags rank 28th in opponent TD scoring percentage in the red zone).
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $150
