Los Angeles Chargers vs. Las Vegas Raiders Picks and Prediction for Monday, September 15th, 2025
Use Code WWWC The Los Angeles Chargers (1-0, 1-0 ATS, 1-0 O/U) meet with the Las Vegas Raiders (1-0, 1-0 ATS, 0-1 O/U) in a divisional clash on Monday night, and we have the prediction. The Chargers posted a big win against the Chiefs to begin their season. The Raiders come away with a dominating road win against the Patriots. The Chargers went 2-0 against the Raiders last season.
Can Herbert and the Chargers take this one by more than a field goal on Monday? Check out the Chargers vs. Raiders prediction. Do you need a boost in your handicapping? Try our NFL Betting Picks!
Chargers Defeat Chiefs in Opener
The Los Angeles Chargers are seeking a second straight win to begin the season. Los Angeles is a true contender in the tough AFC. The Chargers have a similar roster to last season on a team that registered an 11-6 mark. The Chargers opened the season in Brazil against the Chiefs and earned an exciting 27-21 win in a matchup that had the Chargers marked as the three-point dogs. A win in this one would be huge, considering they have yet to play a home game.
Justin Herbert had a magnificent 2024 season, posting nearly 3900 passing yards and a sparkling 23:3 TD to INT ratio. The 27-year-old QB threw for 318 yards in the opener. The offense is expecting a productive rookie season out of Omarion Hampton. The 22-year-old was their first-round pick out of North Carolina. Hampton had plenty of action to begin his career last week, posting 48 rushing yards. They also have a veteran running Najee Harris to help guide Hampton.
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The receiving core is strong. Ladd McConkey was key in the win last week, bringing in 74 receiving yards. Quentin Johnson recorded 711 receiving yards last year and was superb in the opener, recording 79 yards. The Los Angeles offense averaged 320 yards last season. They registered 319 passing yards and 90 rushing yards in the opener.
The Chargers' defense is a strength. The group was subpar against a potent offense last week, conceding 347 yards to the K.C. offense. This is a proven defense with big names and stars, including Derwin James Jr. and Khalil Mack. They kept opponents to an average of 330 yards per game last year and gave up 347 yards against a potent offense in the opener.
Los Angeles averaged 23 points per game last year, ranking them 13th. The Chargers kept opponents to only 18.5 points, good for second.
Raiders Post Minor Upset Road Win
The Las Vegas Raiders are seeking their second win. There is optimism this season, but also quite a few question marks after posting a poor 4-13 record last year. Las Vegas has made a variety of new signings to revamp the offense, but it remains unproven, while the defense could be a weakness. The Raiders earned a minor 20-10 upset road win against the Patriots to begin the season in a clash that had them as 2.5-point dogs.
Geno Smith is the new #1 QB. The veteran QB has been the starter in Seattle for several seasons. Smith posted huge numbers last year, netting 4320 passing yards accompanied by a 20:15 TD to INT ratio. He was dominant in the opener, exposing the Patriots' defense for 362 yards.
The rushing offense could be interesting. Ashton Jeanty was the best running back in the NCAA last year with Boise State. He struggled a bit in his debut last week, rushing 19 times for 38 yards. The receiving core is below average. Brock Bowers is a potent tight end. He sustained a knee injury last week and is questionable for this game. Jakobi Meyers is the #1 WR. The 28-year-old enjoyed a great 2024 season, racking up 1016 receiving yards. Las Vegas averaged 333 yards per game last season and posted 386 yards against the Patriots.
The Raiders' defense could be a weakness. The unit does have a true star in defensive end Maxx Crosby, who made one sack in the win last week. Their other defensive end, Malcolm Koonce, also posted a sack. The Raiders lost key pieces in the secondary in the offseason, including CB Jackson Jones. The defense conceded an average of 333 yards per game last season and was strong in the win last week, keeping New England to 336 total yards.
Las Vegas posted an average of 18.2 points last year, placing them 29th. The Raiders squandered an average of 25 points, placing them 25th.
Chargers vs. Raiders Pick
Spread Pick for Chargers vs. Raiders
- Los Angeles Chargers -3.5 (5 units)
The Los Angeles Chargers are again considered Super Bowl contenders. The Chargers are confident after a huge win against the Chiefs in the opener. The Las Vegas also won their opener, but it was against a subpar Patriots team that only went 4-13 last season.
Furthermore, Las Vegas won last week due to the play of Geno Smith under center. The veteran QB has a completely different challenge this week against a proven Chargers defense. The Chargers kept opponents to an average of only 209 passing yards per game last year, marking them seventh. Also, the Chargers had no issues against the Raiders last season, winning each meeting by double digits. Also, I expect Justin Herbert to expose the Raiders. They have a weak secondary, which is considered one of the worst in the NFL. Herbert posted 346 passing yards in his previous meeting against this defense.
Over/Under Pick for Chargers vs. Raiders
- Under (5 units)
I expect this one to go under. The Chargers held Las Vegas to a total of only 30 points in the two meetings last season. Last week, the defense kept Mahomes and his team to 21 points. Geno Smith is known for throwing interceptions in the red zone and can't be trusted against this potent group. Raiders' RB Ashton Jeanty struggled in his NFL debut for L.V., averaging 2.0 yards per rush.
In addition, the Raiders' defense was strong in the win last week, keeping New England to a 29% efficiency on third downs. Also, Los Angeles had a slow offense last year, ranking 29th in offensive plays per game. Dating back to last season, the Raiders have conceded 15 or fewer points in four of their past five games. The under is a convincing 5-1 in the Raiders' previous six games.
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