Los Angeles Rams at San Francisco 49ers Picks and Prediction, Sunday, November 9th, 2025
Use Code WWWC In this Rams at 49ers prediction, the Rams head to San Francisco, hoping to avenge an earlier loss to the 49ers this season. The Rams are 6-2 with three straight wins, while the Niners check in at 6-3 after a win over the Giants in New York last week. These teams met on Oct. 2, with the Niners winning 26-23 in overtime on a Thursday night in Los Angeles. Both teams combined to throw for over 700 yards in the air. The top of the NFC West Division is on the line in Santa Clara this week in this matchup of conference rivals. The opening kick is scheduled for 4:25 pm EST. If you need quality winners, this is the ultimate site for NFL Picks.
Rams Out for Revenge
The Los Angeles Rams picked up their third straight win last week, in a 34-10 victory over the Saints in LA. It marked the second straight week that the Rams’ offense scored over 30 points while holding the opposition to ten points or fewer. The Rams will now try to upend a 49ers team that upset them in LA, 26-23 in overtime, in week six.
"Here's what I like. I like the fact that we're getting better.” head coach Sean McVay said after the win. “I can feel us starting to play really good complementary ball, especially offensively and defensively off of one another. I think we're getting out to some early leads where you feel like you have a little bit of command. Relinquished a little bit of momentum at the end of the half when they cut it to a 10-point game, but you could feel our guys came out."
Quarterback Matthew Stafford had another big afternoon in what is becoming an MVP-level season for the veteran signal-caller. He finished the game 24-of-32 for 281 yards and four touchdowns. In the team’s last five games, Stafford has thrown 16 touchdowns without an interception. Wide receiver Davante Adams had two touchdown catches, and Puka Nacua returned to the lineup and had seven catches for 95 yards and a touchdown. Running back Kyren Williams rushed for 114 yards and a touchdown in the one-sided win. The Rams finished with 438 yards of total offense.
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The Rams’ defense continued to shine, allowing just 10 points one week after giving up seven points. They held the Saints to just 10 first downs in the game, and 2-of-11 in conversions. In all, the Saints had just 224 yards of total offense, including 57 yards on the ground. The Rams forced two turnovers in the game, including an interception from Emmanuel Forbes Jr. Kamren Kinchens and Nate Landman each led the team with five tackles.
The Rams come into this contest ranked 8th in the NFL in points per game. They are 20th in rushing and top the NFL in passing. The Rams are fifth in the NFL in red zone offense. They’ve done a good job of keeping Stafford upright, ranked sixth in sacks allowed this season. On the defensive end, the Rams are second in scoring defense. They rank eighth against the run and 13th against the pass. The Rams are tough in the red zone, ranked second in the league. They are third in sacks per game this season and second in fewest penalty yards per game. The Rams are seventh in the league in turnover margin.
Key Injuries: CB Darious Williams (shoulder) and WR Puka Nacua (chest) are questionable.
Niners Look to Leapfrog the Rams in the Standings
The San Francisco 49ers got back in the win column on Sunday, thanks to a 34-24 win over the Giants in New York. The win came at a cost; rookie defensive end Mykel Williams tore his ACL and will be lost for the season. The key to the game was the 49ers’ ground game. Ranked last in the league in rushing coming into the contest, the team rushed 39 times for 159 yards.
“Collectively as a team, we were able to stick with it,” Head coach Kyle Shanahan said. “It was a huge team deal getting those run calls.”
The running game was the story on Sunday against the Giants, led by Christian McCaffrey. The former All-Pro finished with 106 yards rushing on 28 carries and a touchdown. He added 67 yards receiving on five catches. Fellow running back Brian Robinson Jr. contributed 53 yards on just five carries, including an 18-yard touchdown. Quarterback Mac Jones was efficient, finishing 19-of-24 for 235 yards and two touchdowns. McCaffrey caught one of the touchdown passes, and Jauan Jennings had the other. The Niners finished with 380 yards of total offense.
Defensively, the 49ers allowed 296 yards of total offense to the Giants. They held the Giants to just 5-of-12 on third down conversions. Tatum Bethune had a huge day with 16 tackles to lead the Niners. The team finished with two sacks in the game and three tackles for loss. Sam Okuayinonu and Clelin Ferrell each had a sack in the game.
The Niners are just 23rd in the league in points per game. They rank last in the league in rushing and fifth in passing. The Niners are 14th in red zone offense and 11th in sacks allowed per game. Defensively, the Niners are 10th in points allowed per game. They rank 14th against the run and 20th against the pass. The team is eighth in red zone defense. They are last in the league in sacks per game. The Niners are 7th in fewest penalty yards per game and 29th in turnover margin.
Key Injuries: WR Brandon Aiyuk is out. LB Bethune (thigh), QB Brock Purdy (toe), WR Rickey Pearsall (knee), DE Bryce Huff (hamstring) and C Jake Brendel are questionable.
Rams vs. 49ers Pick
Point Spread Pick for Rams vs. 49ersÂ
- Rams -4.5 (4 units)
The Rams are putting together a dynamic season on both sides of the ball. They are superior to the Niners offensively, ranked 8th in scoring and first in passing. The Rams are also vastly superior defensively, ranked second in scoring defense and second in red zone defense. That will play big here, with the Rams forcing field goal opportunities instead of touchdowns. The Rams’ offense is fifth in the red zone, which should translate to touchdowns instead of field goals. They were flat in the first meeting against the Niners on a Thursday night. Don’t expect that kind of effort here against a Niners team that struggles to get to the passer and ranks just 20th against the pass; a recipe for disaster against the NFL’s top-ranked pass attack.
Take the Rams -4.5
Over/Under Pick for Rams at 49ersÂ
- Under 49.5 (4 units)
The first game between these two teams went under the number. The 49ers are just 23rd in the NFL in points per game this season, and the Rams are second in scoring defense. As noted above, the Rams have the second-best red zone defense in the NFL. That should translate into more field goal attempts for the Niners than touchdowns. I expect the Rams’ defense to rule the day against the Niners.
Take the under, 49.5
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