Rams vs. Cardinals, Picks and Prediction, Sunday, December 7, 2025
Los Angeles (9-3) will be trying to take sole possession of first place in the NFC West when they visit State Farm Stadium on Sunday afternoon to face Arizona (3-9) at 4:25 PM. ET. Read on to find out which team picks up the win in this Rams vs. Cardinals prediction. Don’t get penalized. Increase your bankroll with our NFL Picks!
The Rams are coming off a 31-28 loss to Carolina as 10-point favorites. The Cardinals are coming off a 20-17 loss to Tampa Bay as 4.5-point underdogs.
Los Angeles is 7-3 in its last 10 games against Arizona.
Rams Trying To Bounce Back From Loss
The Rams had their six-game winning streak snapped by Carolina in their last game. They will try to bounce back from the loss and take sole possession of first place in the NFC West when they play on Sunday.
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Los Angeles averages 27.8 points per game, which is sixth in the league. They throw for 246.6 yards and rush for 113.5 yards per game.
Matthew Stafford has completed 66 percent of his passes for 3,073 yards, 32 touchdowns, and four interceptions. Stafford is coming off a poor start, where he threw two picks. He had an NFL record 28 straight TD passes without an interception until facing the Panthers. Kyren Williams leads the team with 183 carries for 868 yards and seven touchdowns, while Puka Nacua has 86 catches for 1,019 yards and four touchdowns.
Los Angeles is giving up 17.5 points per game, which is second in the league. They’re giving up 207.3 passing yards and 107.8 rushing yards per game.
Key Injuries for Rams:
- CB-Darious Williams (Leg) is doubtful. Has 15 tackles and a pick.
- DT Poona Ford (calf) is questionable. Has 14 tackles and a sack.
Cardinals Trying To Snap Four-Game Losing Streak
The Cardinals followed up their win over Dallas with four straight losses. They will try to snap their losing streak and pick up their first division win of the season when they play on Sunday.
Arizona averages 22.1 points per game, which is 20th in the league. They throw for 236.7 yards and rush for 100.6 yards per game.
Jacoby Brissett has completed 68 percent of his passes for 2,188 yards, 13 touchdowns, and four interceptions. Bam Knight leads the team with 74 carries for 255 yards and four touchdowns, while tight end Trey McBride leads the team with 88 catches for 879 yards and eight touchdowns.
Arizona is giving up 25.3 points per game, which is 24th in the league. They’re giving up 219.6 passing yards and 112.6 rushing yards per game.
Key Injuries for Cardinals:
- WR-Marvin Harrison Jr. (Heel) is out. Number one wide out.
- QB Kyler Murray (foot) is out for the season. Former starting QB.
- CB Max Melton (heel) is out. Has 21 tackles.
Rams vs. Cardinals Picks
Point Spread Pick for Rams vs. Cardinals
- Los Angeles Rams -9 (4 Units)
The Rams have won six of their last seven games, while the Cardinals have lost nine of their last 10 games. Los Angeles has the edge here because they has one of the best offenses in the league, and can beat opponents through the air and on the ground. The Cardinals have struggled against the pass, and they haven’t been much better against the run, so expect them to have a hard time slowing down the Rams.
Arizona will have a hard time keeping up offensively because they’re one-dimensional. They have a good passing game, but their ground game is one of the worst in the league. With the Rams not having to worry about the Cardinals beating them on the ground, expect them to tee off on Brissett and force him to make costly mistakes. Go with Los Angeles to cover the spread.
Over/Under Pick for Rams vs. Cardinals
- Under 47.5 (4 Units)
The Rams average 27.8 points per game. They throw the ball 57 percent of the time with the fourth-ranked passing attack in the league, and they’re facing a team that is 14th against the pass and is giving up 25.3 points per game. The Cardinals average 22.1 points per game. They throw the ball 64 percent of the time with the eighth-ranked passing game in the league, and they’re facing a team that is giving up 17.5 points per game. Don’t expect these teams to score enough points to push the score over the total.
