New York Giants vs New Orleans Saints Prediction and Picks - October 5th, 2025

Sunday afternoon on the NFL gridiron, and we have a New York Giants vs New Orleans Saints Prediction locked and loaded for you. The Giants enter this game at 1-3 on the year and off a 21-18 home win over the Chargers. The Saints are having a tough go of it as they come in off a 31-19 loss at Buffalo to fall to 0-4 on the year. These teams met last year, and the Saints won that game 14-11. Which team will grab a much-needed win today? Read on to see our Giants vs Saints prediction.

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Giants Break Through With A Win

The Giants finally broke through last week with a 21–18 win over the previously undefeated Chargers, and the story was all about rookie quarterback Jaxson Dart. Making his first NFL start, Dart showed poise and toughness, throwing for a touchdown, running for another, and shaking off a brief injury scare to lead New York to its first win of the season. He finished 13-of-20 for 111 yards and added 54 rushing yards on 10 carries, including a 15-yard score to cap a 90-yard opening drive. The offense leaned heavily on Cam Skattebo, who carried the ball 25 times for 79 yards, while Theo Johnson caught Dart’s lone touchdown pass. The defense stepped up late, with Brian Burns sacking Justin Herbert and Cor’Dale Flott making a game-saving tackle to seal the win.

With Dart now firmly in command, the Giants’ offense has a different rhythm — more movement, more bootlegs, and a greater emphasis on misdirection. Skattebo’s workload suggests a commitment to ball control, and the offensive line held up well against a fierce Chargers front. Defensively, New York forced two turnovers and held Los Angeles scoreless in the fourth quarter, showing improved discipline and tackling. Burns and Kayvon Thibodeaux combined for two sacks, while Jason Pinnock and DeMarvion Overshown were active in coverage. The secondary remains a work in progress, but the unit is trending upward after a shaky start to the season.

Heading into the Superdome, the Giants face a Saints team that’s physical up front and opportunistic in coverage. Dart’s mobility will be key in neutralizing New Orleans’ pressure packages, and Skattebo’s ability to grind out tough yards could help quiet the crowd and extend drives. With Malik Nabers done for the year, expect more targets for Darius Slayton and Wan’Dale Robinson, especially on quick outs and crossers. Defensively, New York will need to contain Alvin Kamara in space and force Derek Carr into contested throws. If the Giants can replicate their Week 4 formula — run-heavy offense, timely defense, and mistake-free quarterback play — they’ll have a chance to build momentum in a hostile environment.

Saints Still Winless On The Year

The Saints return to the Superdome at 0–4 after a 31–19 loss to Buffalo, a game that showcased both flashes of fight and the same frustrating inability to finish drives. Rookie quarterback Spencer Rattler completed 18-of-27 passes for just 126 yards and a short touchdown to Chris Olave, but the offense stalled repeatedly in scoring range. New Orleans crossed midfield on nine of its first ten possessions yet came away with just two field goals, a touchdown, and a trick-play interception thrown by Olave. Kendre Miller provided a spark with 65 rushing yards and an 18-yard touchdown, but Alvin Kamara was held to 58 total yards and stuffed on a key fourth-down late. Rattler, now 0–10 as an NFL starter, continues to show flashes — 67.1% completion rate and a 5:1 TD-to-INT ratio this season — but the offense has yet to find rhythm or vertical threat.

Statistically, the Saints rank 28th in scoring offense (16.5 PPG) and 22nd in total yards (301.0 YPG), with a run-heavy profile that’s produced 496 rushing yards through four games (10th in the NFL). Kamara leads the team with 256 yards on 65 carries, while Juwan Johnson has emerged as the top pass-catcher with 204 yards on 22 receptions. Olave and Rashid Shaheed have combined for 359 yards and two touchdowns, but explosive plays have been rare — New Orleans ranks 27th in yards per pass attempt (5.1) and 30th in sacks allowed (9). Defensively, the Saints sit 18th in total defense (324.0 YPG) and 15th against the pass (222.5 YPG), with Carl Granderson leading the team with 4.5 sacks and Demario Davis pacing the unit with 38 tackles. The secondary has held up reasonably well, but the lack of turnovers and red zone stops has kept the defense on its heels.

Against the Giants, New Orleans must simplify the game plan for Rattler and lean heavily on Kamara and Miller to control tempo. Expect more quick throws, designed rollouts, and motion to help Rattler identify coverage and avoid pressure. Olave will remain the primary target, but Juwan Johnson and Shaheed could see increased usage in short-yardage and red zone packages. Defensively, the Saints will look to bottle up Cam Skattebo and force Jaxson Dart into tight-window throws, especially with Malik Nabers nursing a knee injury. If New Orleans can generate early stops and give Rattler manageable situations, they’ll have a chance to reset the tone — but at 0–4, urgency is no longer optional. This is a must-win game for a team trying to salvage its season before the schedule tightens.

New York Giants vs New Orleans Saints Pick

Giants vs Saints Spread Pick

• New Orleans -2 (5 Units)

Saints -2 is a sharp angle in a matchup where New Orleans’ defense and home-field edge align well against a rookie quarterback making his first road start. Spencer Rattler hasn’t lit up the box score, but he’s protected the ball and shown enough command to keep the offense functional. With Alvin Kamara and Kendre Miller splitting touches and Chris Olave drawing coverage, the Saints should be able to control tempo and force the Giants into a slower, grind-it-out game. Defensively, New Orleans has the personnel to contain Cam Skattebo and pressure Jaxson Dart, especially with Carl Granderson and Demario Davis leading a front that’s been disruptive despite the team’s 0–4 record.

The situational trend adds weight: the Giants are just 1–6 ATS in their last seven games played in a dome, struggling to adjust to faster surfaces and crowd noise. Dart’s mobility is a weapon, but the Saints’ secondary has held up well in man coverage and should be able to limit explosive plays. If New Orleans can get early stops and avoid the red zone stalls that plagued them against Buffalo, they’re well-positioned to cover this short number. With urgency high and the Superdome behind them, this sets up as a bounce-back spot for a team that’s been more competitive than their record suggests.

Giants vs Saints Over/Under Pick

• Under 42 (4 Units)

Under 42 makes sense in a matchup where both offenses lean conservative and both defenses have shown enough to limit explosive plays. The Saints are averaging just 16.5 points per game and rank bottom five in yards per pass attempt, while the Giants are starting a rookie quarterback on the road in a hostile dome. Expect New Orleans to lean on Kamara and Kendre Miller to control tempo, while New York will likely protect Jaxson Dart with a run-heavy script and short throws. With both teams struggling to finish drives and red zone efficiency lagging, this sets up for a possession-driven game with limited scoring bursts.

The trend adds weight: the Giants are just 1–12 to the Under when listed as a non-division favorite or underdog of 3 points or fewer — a signal that tight spreads and unfamiliar opponents tend to produce lower totals in their games. Combine that with the Saints’ red zone inefficiency and the Giants’ dome struggles, and the Under becomes even more attractive. If the defenses hold serve early and neither team finds rhythm through the air, this game could grind well below the number.