NFL Best Bets For Week 4 from NFL Betting Experts

By: Dean Whitaker Published 09/28/2025, 09:51 AM ET
George Kittle looks to lead the Niners over the Jaguars
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Week 4 of the NFL season is here, and we’re locked in after a 1-2 slip last week. The board is packed with opportunities, and we’ve circled three games that bring real value. Backed by matchup breakdowns, key trends, and sharp insight, these plays are built to deliver winners and get us rolling in the right direction this Sunday.

Last Week's Results

  • Las Vegas +3.5 (Loss)
  • Houston/ Jacksonville Over 43.5 (Loss)
  • Seattle -7.5 (Won)

Below, let's take a look at some of my favorite NFL picks for today, in best bets form.

The Patriots Kick Off This Week's Best Bets

New England enters Sunday’s matchup against Carolina laying 5 points, and the Patriots are positioned to bounce back after a turnover-heavy loss to Pittsburgh. Rookie QB Drake Maye has shown poise, completing 72.6% of his passes for 785 yards and five touchdowns through three games. Tight end Hunter Henry remains his go-to target, while the backfield rotation of Antonio Gibson and TreVeyon Henderson offers versatility against a Panthers defense allowing 4.3 yards per carry. Carolina’s secondary has been inconsistent, and New England’s pass game should find enough success to build a lead at home.

Carolina, meanwhile, is coming off a 30–0 win over Atlanta—but history isn’t on their side. The Panthers are 0–10 ATS in their last 10 games following a 27+ point outing, and they’ve struggled to sustain momentum week-to-week. Bryce Young threw for just 121 yards in that win, and the offense remains limited in explosive plays. New England’s rush defense ranks second in the NFL, allowing just 2.8 yards per carry and zero runs over 20 yards. If the Patriots protect the ball and control tempo, they’re well-positioned to cover the number with a 26–17 or 24–13 type result.

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Best Bet#1

  • New England -5

Best Bet #2 - Vikings Grab Huge Road Win

The Vikings enter Sunday’s matchup against Pittsburgh laying 2.5 points, and they’re well-positioned to cover behind a surging offense and a defense that’s quietly improved. Jaren Hall has settled in as the starter, throwing five touchdowns over the last two weeks while minimizing turnovers. Minnesota’s offensive line has kept him clean, allowing just two sacks in that span, and the emergence of rookie WR Troy Franklin alongside Jordan Addison gives Hall multiple vertical options. Pittsburgh’s secondary has been vulnerable to deep shots, ranking bottom-10 in explosive pass plays allowed, and Minnesota’s tempo could stretch them early.

Defensively, the Vikings have held opponents under 20 points in back-to-back games and rank top-five in third-down stops. Pittsburgh’s offense, led by Kenny Pickett, has struggled to sustain drives and ranks 29th in yards per play. The Steelers are also dealing with injuries on the offensive line, which could open the door for Minnesota’s pass rush to take over late. With the Vikings playing at home, protecting the ball, and showing more balance on both sides, they’re well-equipped to cover the number in a 24–20 or 27–21 type finish.

Best Bet #2

  • Minnesota -2.5

A High-Scoring Jags/Niners Game Out Today's Best Bets

Jacksonville has shown enough offensive consistency to make this total achievable, averaging 23.3 points and 356 yards per game. Trevor Lawrence has led a passing attack that produces nearly 215 yards per contest, and the run game has been balanced at just over 111 yards per outing. With playmakers like Christian Kirk and Travis Etienne, the Jaguars are built to create chunk plays and have the ability to finish in the red zone. Their efficiency gives them a strong chance to land in the mid-20s again, setting a solid base for the Over.

San Francisco, despite averaging only 19.3 points per game, moves the ball well at 361 total yards per contest and has the talent to break through against Jacksonville’s secondary. Brock Purdy has plenty of options with Ricky Pearsall and George Kittle in the passing game, while Christian McCaffrey’s dual-threat ability makes the Niners dangerous both on the ground and through the air. Even modest scoring drives from San Francisco paired with Jacksonville’s steadier output could turn this into a game that climbs into the high 40s. With both offenses capable of sustained drives and explosive plays, Over 46 has value in what projects as a competitive matchup.

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Best Bet#3

  • Jacksonville/San Francisco Over 46

Recapping today's NFL Best Bets

  • New England -5
  • Minnesota -2.5
  • Jacksonville/ San Francisco Over 46

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