San Francisco 49ers at Cleveland Browns, Preview, Odds, Picks and Prediction, Sunday, November 30, 2025
It’s an intra-conference clash on Sunday, Nov. 30. Read our San Francisco 49ers vs Cleveland Browns prediction along with the our other NFL Picks! The 49ers are 8-4 and they are battling for the divisional lead. San Francisco has won back-to-back games on the road, but this will be a tough test against one of the best defenses in the sport. Cleveland’s confidence is high after dominating Las Vegas last week. The Browns have a 3-8 record and excitement is building around rookie quarterback Shedeur Sanders. These two teams will meet with kick-off set for 1 P.M. EST.
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San Francisco battling for NFC West lead
San Francisco is 8-4 overall this season. The 49ers are in third place in the NFC West as they are just behind the 9-2 Rams and the 8-3 Seahawks. San Francisco is 5-2 when they have played on the road this year. The 49ers have won three of their last four games coming into Sunday. They have also won back-to-back road games.
In their last game, the 49ers defeated Carolina 20-9 on Monday, Nov. 24. It was a straightforward victory for San Francisco as they never trailed throughout the game. Quarterback Brock Purdy threw for 193 yards on 23-for-32 passing. He threw one touchdown and tossed three interceptions. Christian McCaffrey put together a strong game with 89 yards and a touchdown.
Purdy is back playing for the 49ers, having missed part of the season due to injury. He has played in four games this year and has thrown for 979 yards and has completed 68.7% of his throws. He’s tossed eight touchdowns and seven interceptions on the year. McCaffrey still leads the running back room with 796 rushing yards and seven touchdowns. McCaffrey is also the team's best wide receiver with 785 yards and a team-high five touchdowns.
On defense, San Francisco Dee Winters leads the team with 78 tackles, which is 11 more than anyone else on the roster. Bryce Huff has a team-high four sacks, while the defense has forced 12 turnovers.
San Francisco is averaging 13.4 points per game, which ranks 15th. They are the third-best passing attack with 249.4 yards per game. The 49ers are averaging 99.2 rushing yards per game, placing them 26th.
On defense, San Francisco is allowing 21.8 points per game, which ranks 11th. They are the ninth-best rush defense, giving up 100.9 yards per game. The 49ers are also allowing 241.6 pass yards per game, placing them 26th.
San Francisco is 7-5 against the spread this season. They are 5-2 against the spread on the road this season. The 49ers are 5-2 against the spread when they have been favored. The over is 7-4-1 when the 49ers have played this season. The over is 5-1-1 when San Francisco has played on the road.
Key Injuries for 49ers
- LB Tatum Bethune (ankle), out
- DT Sam Okuayinonu (ankle), out
- K Eddy Pineiro (hamstring), out
Myles Garrett close to history for the Browns
Cleveland is 3-8 overall this season. The Browns are in last place in the AFC North, but they aren’t far off third-place Cincinnati, who have a 4-8 record. The divisional lead is set by the Steelers with a 6-5 record. Cleveland is 2-3 when they have played at home this season. The Browns have won two of their last five games.
In their last game, Cleveland defeated the Raiders on the road 24-10 on Sunday, Nov. 23. It was rookie quarterback Shedeur Sanders’ first NFL start and he helped lead the Browns to a win. He’s the first quarterback to make his NFL debut and win for the Browns in that game since the 1990s. Sanders tossed 209 yards on 11-for-20 passing with a touchdown and an interception. But it was the defense that was a major highlight in the game as they earned 10 sacks and forced a fumble, allowing just 268 yards on 75 plays.
Despite Cleveland’s poor record, it’s been a historic season so far for Myles Garrett. He’s closing in on the most sacks in a single season. Garrett is currently at 18 total sacks, which is 4.5 sacks off of the NFL record. Garrett has more sacks than the entire 49ers defense this year.
Cleveland is averaging 16.9 points per game, which ranks fourth-worst in the league. They are the second-worst passing offense, averaging 163.5 yards per game. The Browns rank 28th in rushing attack with 94.9 yards per game on the ground.
On defense, Cleveland is allowing 22.2 points per game, which ranks 12th best. They are the second-best pass defense, giving up 170.7 yards per game. The Browns rank 10th in rush defense, surrendering 102.3 yards per game on the ground.
Cleveland is 5-6 against the spread this season. The Browns are 4-1 against the spread when they have played at home. Cleveland is 3-2 against the spread when they have been underdogs by 4.5 points or less. The over is 6-5 when Cleveland has played this season. The over is 3-2 when the Browns have played at home.
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Injuries for Browns:
- TE Brenden Bates (ankle), out
- DT Adin Huntington (quad), out
- DE Alex Wright (quad), out
- RB Jerome Ford (hamstring), questionable
San Francisco 49ers vs Cleveland Browns Picks
49ers vs Browns Spread Pick
- Cleveland Browns +4.5 (5 units)
The 49ers are coming off of a short week of practice after playing on Monday night. They came away with the win against Carolina, but it wasn’t perfect. Brock Purdy tossed three interceptions and he is likely to turn the ball over again versus the Browns. Cleveland’s defense is elite as Myles Garrett is close to breaking the NFL record for most sacks in a season. Cleveland is always a tough game at home, and with the crowd on the side of Sanders, the Browns' stadium should be bumping. Cleveland’s defense will keep this game close as San Francisco hasn’t been able to blow teams out recently. The Browns will make the plays necessary and cover the spread. They are 3-2 against the spread as a 4.5 point underdog or less. They are also 4-1 against the spread at home.
Take Cleveland to cover.
49ers vs Browns Over/Under Pick
- Under 36.5 (5 units)
The Browns have one of the best defenses in the NFL. They get after the quarterback easily and can force turnovers. Brock Purdy threw three interceptions to a worse defense in Carolina last week. The Browns will force turnovers and keep San Francisco out of the end zone. Cleveland will also be starting Sanders for his second start and he will struggle at times as he continues to adjust to the NFL speed of the game.
Take the under on Sunday.
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