San Francisco 49ers vs. Tampa Bay Buccaneers Picks and Prediction, Sunday, October 12, 2025
Use Code WWWC It’s another big game in the NFC between two of the team teams in the conference on Sunday, Oct. 12. Read our San Francisco 49ers vs Tampa Bay Buccaneers prediction along with with our other NFL Picks! Both teams are 4-1 and they are both struggling with injuries to some key players. The 49ers are coming off of an OT win over the Rams while injuries to wide receivers and the quarterback position persist. The Buccaneers are coming off of a miraculous win over Seattle while wide receiver injuries continue for them, too. These two teams will meet with kick-off set for 4:25 P.M. EST.
San Francisco coming off big OT win
San Francisco is 4-1 overall this season. The 49ers are started the season with three straight wins with victories over Seattle, New Orleans, and Arizona. Their lone loss was a 26-21 defeat to the Jaguars in Week 4.
In their last game, the 49ers defeated the Rams 26-23 in OT on Thursday, Oct. 2. The 49ers held a 3-point lead thanks to an Eddy Pineiro 59-yard field goal late in the game. But the Rams were able to tie the game to send it to OT. The winning points came from another long field goal from San Francisco. The 49ers' defense came up clutch, stopping the Rams on fourth down to secure the win in OT.
Quarterback Mac Jones threw for 342 yards on 33-for-49 passing and two touchdowns. Wide receiver Kendrick Bourne was big with 142 yards on 10 catches. Christian McCaffrey continues to play a major role with 57 rushing yards and 82 receiving yards along with a touchdown.
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Starting quarterback Brock Purdy is unlikely to play against Tampa Bay. Jones has started the past three games, but he is dealing with knee and oblique injuries. It looks like Jones will be able to play through the pain, according to him.
“[I'm] just getting treatment every day and working," Jones said. "I feel confident and just working through it day by day. That's all you can do."
With both quarterbacks sidelined, Adrian Martinez has been getting snaps with the first team this week. He’s been the backup quarterback to Jones through this stretch. Martinez has never played a regular-season game with San Francisco.
McCaffrey continues to be the best weapon for the offense. He leads the team in receiving and rushing yards. The 49ers have not scored a rushing touchdown all season, though.
On defense, linebacker Fred Warner leads the team with 50 tackles, which is 11 more than anyone else. Defensive end Bryce Huff leads the team with three sacks, while the defense has forced just four turnovers.
San Francisco is averaging 21.2 points per game, which ranks 22nd in the league. They are the best passing offense in the league as they are averaging 290.6 passing yards per game. The 49ers are rushing for 85.2 yards per game on the ground, which ranks fifth-worst.
On defense, the 49ers are allowing 19.6 points per game which ranks sixth best. They are allowing 207.6 passing yards per game which places them 14th. San Francisco is the 15th ranked rushing yards giving up 108 yards per game.
San Francisco is 3-2 against the spread this season. They are 1-0 against the spread as an underdog as they defeated the Rams in OT in Week 5. The 49ers are 3-0 against the spread when they have played on the road. The over is 3-2 when San Francisco has played this season. The over is 2-1 when the 49ers have played on the road. The over is 2-1 when the total has been set at 44 or higher.
As of Thursday, defensive end Robert Beal Jr., defensive end Yetur Gross-Matos, wide receiver Ricky Pearsall, quarterback Brock Purdy and wide receiver Jordan Watkins did not participate in practice. Defensive tackles Alfred Collins, Kalia Davis and Kevin Givens were all limited in practice. Wide receiver Jauan Jennings, quarterback Mac Jones, corner Upton Stout and defensive tackle CJ West were all limited, too.
Tampa Bay flying high in spite of injuries
Tampa Bay is 4-1 overall this season. The Buccaneers opened the season with three straight wins over Atlanta, Houston and the Jets. The Buccaneers had their first loss in Week 4 as they were defeated by the Eagles by 6 points.
In their last game, the Buccaneers were able to bounce back with a 38-35 road win over Seattle on Sunday, Oct. 5. Tampa Bay secured a big come-from-behind win as Seattle took a 35-28 lead with 3:18 left in the game. Quarterback Baker Mayfield made an 11-yard touchdown pass to Sterling Shepard to tie the game at 35-35 with 1:08 left.
“[He is] very underrated,” Tampa Bay head coach Todd Bowles said of Shepard. “One of our most underrated players, but one of our best players. He knows what to do, how to do it. He’s very tough. He can play inside, he can play outside. He’s done a great job blocking this year as well. He finds the open spots, and him and Baker [Mayfield] have a connection that way. He kept us in the game.”
On Seattle’s next possession, Sam Arnold was intercepted by Lavonte David. The big turnover set up Tampa Bay for a game-winning field goal. Mayfield threw for 379 yards on 29-for-33 passing and two touchdowns. Wide receiver Emeka Egbuka caught 163 yards and a touchdown, too.
Two of Mayfield’s big weapons will be missing in this game in wide receivers Chris Godwin and Mike Evans are out with injuries. Thankfully, rookie Egbuka has been great. He leads the team with 445 receiving yards and five touchdowns. Mayfield has thrown for 1,283 yards and has completed 65% of his throws. He’s tossed 10 touchdowns and one pick.
On defense, Tykee Smith leads the team with 39 tackles. The roster has 10 sacks with Vita Vea leading the team with two total sacks. The defense has forced just four turnovers.
Tampa Bay is averaging 27 points per game, which ranks seventh best. They are the sixth-best passing offense as they are averaging 243.4 yards per game. The Buccaneers are rushing for 110.4 yards per game on the ground, which ranks 23rd.
On defense, the Buccaneers are allowing 26.4 points per game, which ranks 23rd. They are the eighth-ranked rush defense, giving up 92.4 yards per game on the ground. Tampa Bay is also the 19th-ranked pass defense, giving up 218.4 yards per game.
Tampa Bay is 3-2 against the spread this season. They are 1-1 against the spread when they have been favored. The Buccaneers are 0-2 against the spread when they have played at home. The over is 3-2 when Tampa Bay has played this season. The over is 2-0 when Tampa Bay has played at home. The over is 2-1 when the total has been set at 44 points or more.
As of Thursday, wide receivers Mike Evans, Chris Godwin Jr. and running back Bucky Irving did not participate in practice. Corners Zyon McCollum and Benjamin Morrison also missed practice. Linebacker Lavonte David, safety Christian Izien, tackle Tristan Wires and backup quarterback Teddy Bridgewater were all limited participants.
49ers vs Buccaneers Picks
San Francisco 49ers vs Tampa Bay Buccaneers Spread Pick
- Tampa Bay Buccaneers -3 (5 Units)
Tampa Bay has been on fire offensively as Baker Mayfield has put himself in the MVP discussion through the first part of the season. Yes, injuries to the wide receiver position may make this a difficult game, but the emergence of Emeka Egbuka has been fantastic. Last week, the offense was flying around and helped them secure a win over Seattle. The team will be more than comfortable at home to put up a big spot against a San Francisco defense that ranks 14th in pass yards allowed.
If this turns into a high-scoring game, the 49ers will not be able to compete. They don’t have a balanced attack as they have yet to score a rushing touchdown this season. Mac Jones was limited in practice this week with knee and oblique issues, but he is still expected to play. I’m considering this offense to be a little rusty with a lack of reps to key positions, as the Buccaneers will only have to worry about Christian McCaffrey in this game. Tampa Bay’s offense should unleash for a big win.
Take Tampa Bay to cover.
49ers vs Buccaneers Over/Under Pick
- Over 47.5 (5 units)
The offenses for both teams have carried them throughout the first five weeks of the season. Yes, defensive plays have been big, but scoring outputs have been fantastic. This total line is low because of the number of injuries to skill positions. With Baker Mayfield on one end and a Kyle Shanahan-led offense on the other, points will be flying across the board in quick succession. he over is 2-0 when Tampa Bay has played at home. The over is 2-1 when the total has been set at 44 points or more for Buccaneers games. The over is 2-1 when the 49ers have played on the road. For San Francisco, the over is 2-1 when the total has been set at 44 or higher.
Take the over on Sunday.
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