San Francisco 49ers vs. Houston Texans Picks and Prediction for Sunday, October 26, 2025
Week 8 of the 2025 NFL season rolls on with an interconference matchup when the San Francisco 49ers battle the Houston Texans Sunday afternoon in the Lone Star State and we have you covered with our 49ers vs. Texans prediction. San Francisco comes in off a 20-10 home win over Atlanta on Sunday Night Football last week, winning outright as a one-point underdog. Houston fell to Seattle 27-19 on the road in their previous contest on Monday Night Football, failing to cover the line as a three-point underdog. In the all-time regular season series between the teams, the 49ers own a 4-1 advantage and have won the last three meetings, including a 23-7 home win in the most recent matchup on January 2, 2022. Read more about this 49ers vs. Texans prediction! Don’t get sacked this football season! Try our NFL Picks!
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49ers Trying to Maintain At Least Share of NFC West Top Spot
San Francisco bounced back from a loss to Tampa Bay as they doubled up Atlanta at home last Sunday. The 49ers enter this game 5-2 and tied with the Seahawks and Rams for the top spot in the NFC West. Against Atlanta, San Francisco took a 10-3 halftime advantage by scoring 10 points in the final 1:48 of the first half. Their defense stepped up and never let Atlanta closer than three the rest of the way as they earned the victory. The 49ers owned a 324-292 advantage in total offense, picked up 23 first downs while allowing 19 and controlled the clock by a 32:10 to 27:50 margin in the contest. Both teams turned the ball over once in the game.
On the year, the 49ers are 1st in the league in passing as they average 271.3 yards per game through the air. San Francisco is 24th in the league in rushing offense as they pile up 95.3 yards per game on the ground this season. The 49ers are 23rd in the league in scoring offense as they put up an average of 20.7 points per game. San Francisco is 7th in the league in scoring defense by allowing an average of 19.7 points per contest. Brock Purdy is 48 of 73 passing for 586 yards with four touchdowns and four interceptions while getting sacked twice. He adds 30 yards on the ground. Purdy has played in just two games this season due to injuries and it looks like he's going to miss a sixth game.
Mac Jones (130 of 194, 1,404 yards, six TD, four INT, 34 rush yards) has stepped up with Purdy missing time. Christian McCaffrey leads the ground game with 132 carries for 465 yards and three scores. Brian Robinson Jr. (36 carries, 144 yards) is the second back in the system. McCaffrey leads the team with 53 receptions for 516 yards and three scores this season. Jauan Jennings (14 catches, 167 yards, TD), tight end Jake Tonges (25 grabs, 224 yards, three TD), Kendrick Bourne (25 catches, 385 yards) and Ricky Pearsall (20 receptions, 327 yards) are all over 150 receiving yards on the season. Jake Moody was two of two on extra point attempts and one of three on field goal attempts with a long of 32 this season before being cut after the opener. Eddy Piniero is nine of 10 on extra points and 17 of 17 on field goals with a long of 59 on the year.
The 49ers have a lengthy injury report to monitor ahead of this contest. Offensive lineman Jake Brendel (hamstring), Pearsall (knee), defensive back Deommodore Lenoir (quad), along with defensive linemen Yetur Gross-Matos (knee/hamstring) and Bryce Huff (hamstring) all missed practice Wednesday and Thursday. Linebacker Luke Gifford (hamstring) was limited on Wednesday and didn’t practice on Thursday. Offensive lineman Spencer Burford (knee) and Purdy (toe) were limited both days. Watch for updates on their status heading toward kickoff.
Houston Trying to Solve Offensive Woes
Houston sputtered again last week on the road in Seattle and it ended up leading to a loss to the Seahawks coming out of the bye. The Texans fell to 2-4 on the year and stood third in the AFC South, 3.5 games behind the Colts for the top spot. Against Seattle, Houston trailed 14-0 after the opening quarter and never recovered. The Texans scored as many touchdowns (one) defensively as they did on offense, as Will Anderson Jr. recovered a fumble in the end zone to get them with 17-12 in the third quarter. They would get no closer than that as Seattle held them at bay. Houston lost the total yardage battle 316-254, gave up 19 first downs while picking up 18 and lost time of possession by a 32:17 to 27:43 margin. Those numbers offset that the Texans forced four turnovers, including that scoop-six, while committing one.
On the year, Houston is 23rd in passing offense with 198.2 yards per game through the air while they stand 18th in rushing offense with 106.2 yards per contest. Houston is 21st in scoring offense with an average of 21.2 points per game while they are 1st in scoring defense by allowing 14.7 points per contest. C.J. Stroud has completed 125 of 193 passes for 1,305 yards with nine touchdowns and four interceptions. He has been sacked 15 times while adding 147 yards on the ground. Davis Mills is two of four for 23 yards plus three rushing yards as the backup quarterback. Nick Chubb leads the team on the ground with 63 carries for 265 yards and two scores. Dameon Pierce (10 carries, 26 yards) and Woody Marks (46 carries, 152 yards, TD) are next in line on the depth chart. In the passing game, Nico Collins is second on the team with 26 receptions for 339 yards and three scores this season. Xavier Hutchinson (13 catches, 123 yards, two TD), Christian Kirk (10 grabs, 109 yards, TD), Jayden Higgins (nine receptions, 121 yards, TD), Marks (nine grabs, 116 yards, two TD) and Dalton Schultz (30 catches, 284 yards) are solid secondary options. Ka’imi Fairbairn hit all 10 extra point attempts and is 13 of 15 on field goal attempts with a long of 57 this season.
The receiver group could be lacking for the Texans here. Collins (concussion) and Kirk (hamstring) failed to practice on Wednesday and Thursday. Defensive linemen Denico Autry (knee) and Derek Barnett (ankle), along with Schultz (back/shoulder) were limited both days. Defensive end Darrell Taylor (illness) was limited on Thursday. Watch for updates over the weekend.
49ers vs. Texans Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 |  David Hess | +1,326.00 |
| 4 |  Earle Sports Bets | +1,323.00 |
| 5 |  Dan Kaiser | +1,071.00 |
Moneyline Pick for 49ers vs. Texans
- 49ers +118 (4 units)
Houston’s offense continues to be uninspiring as it struggled to generate much against the Seahawks. The Texans seem to see their production dry up in games they lose this season. Houston outscored the opposition 70-10 in their two wins, but they have been outscored 78-57 in their four defeats. You simply aren’t going to win a lot of games putting up 14 points a game. San Francisco has had success despite missing key contributors like Kittle and Purdy, among others. They found ways to win despite all the injuries. The 49ers have the dangerous McCaffrey and they lead the league in passing offense this season. Given how Houston has struggled this season against capable defenses, look for San Francisco to pick up a road win here to improve to 6-2.
Over/Under Pick for 49ers vs. Texans
- Under 41.5 (4 units)
San Francisco snapped a string of three straight overs in last week’s victory over the Falcons. The 49ers have been fairly sound defensively, ranking seventh in the league in scoring defense on the year. Houston has stayed under the number in four of their six games on the year entering this game. The Texans lead the league in scoring defense, stand 10th in rushing defense (95.2 yards per game), tied for sixth in interceptions (seven) and first in passer rating allowed (68.3) on the year. Neither offense sets the world on fire and facing a pair of above-average defenses makes it tougher. That keeps this game under the total.
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