San Francisco 49ers vs Philadelphia Eagles Picks, Prediction, Odds, and Line Movement for Sunday, January 11, 2026
The NFL playoffs begins this week with a really good matchup in the NFC on Sunday, Jan. 11. Read our San Francisco 49ers vs Philadelphia Eagles prediction along with our other NFL Picks! The 49ers are the No. 6 seed with their 12-5 record. San Francisco suffered a loss last week to Seattle, which would have seen them become the No. 1 seed. The Eagles are the No. 3 seed after winning the NFC East. Philadelphia has an 11-6 record and they have won three of their last four games as they look to defend last year’s Super Bowl title. These two teams will meet with kick-off set for 3:30 P.M. EST.
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San Francisco misses out on NFC West title, settles for wild card
San Francisco is 12-5 overall this season. The 49ers had a chance at winning the NFC West last week, but they suffered a loss to the Seahawks, who claimed the No. 1 seed in the NFC. The 49ers closed the season winning six of their last seven games, as they have navigated countless injuries consistently.
In their last game, the 49ers lost 13-3 to Seattle at home on Saturday, Jan. 3. San Francisco’s offense was stymied during the game as they accumulated just 173 yards. They went 2-for-9 on third down and turned the ball over once. San Francisco did not hav the ball very much either. The Seahawks won the ball control battle by over 15 minutes. Quarterback Brock Purdy threw for just 127 yards on 19-for-27 passing while running back Christian McCaffrey could not find any room to rush with 23 yards on eight carries.
It was a tough defeat for the 49ers, but the overall season has gone their way. Purdy has thrown for 2,167 yards and has completed 69% of his passes. He’s thrown 20 touchdowns and 10 interceptions on the season, too. McCaffrey leads the team with 1,202 rushing yards and 10 touchdowns.
On defense, the 49ers are led in tackles through Dee Winters, who has 101 tackles. Clelin Ferrell and Bryce Huff both lead the team with four sacks each. The 49ers have forced 16 turnovers on the year, with 10 of them being fumbles.
The 49ers and the Eagles did not play each other in the regular season.
San Francisco is averaging 25.7 points per game, which ranks 10th best in the league. They are the fifth-best passing offense averaging 244.5 yards per game. The 49ers are averaging 106.9 rushing yards per game placing them 24th.
On defense, the 49ers are allowing 21.8 points per game, which ranks 13th in the league. They are the 11th ranked rush defense, allowing 107.8 yards per game on the ground. San Francisco is allowing 232.4 passing yards per game, which ranks 25th.
San Francisco is 11-6 against the spread this season. The 49ers are 7-2 against the spread this season when playing on the road. They are 2-4 against the spread when they have been underdogs. The over is 10-6-1 when the 49ers have played this season. The over is 6-3 when the 49ers have played on the road. The over is 9-4 when the total has been set at 44 points or more.
Key injuries
- WR Jacob Cowing (hamstring), questionable
- LB Luke Gifford (quadricep), questionable
- CB Renardo Green (ankle), questionable
- WR Ricky Pearsall (knee, ankle), questionable
- DL Keion White (groin, hamstring), questionable
- T Trent Williams (hamstring), questionable
- LB Dee Winters (ankle), questionable
Defending Champs looking to repeat
Philadelphia is 11-6 overall this season. The Eagles won the NFC East easily, with the Cowboys in second place with a 7-9-1 record. Philadelphia finished the regular season with a 5-3 home record. The Eagles have won three of their last four games. Before this run, the Eagles were on a three-game losing skid, but they were able to bounce back and end the season strong.
In their last game, the Eagles lost to Washington 24-17 at home on Sunday, Jan. 4. The Eagles rested a majority of their starters with quarterback Jalen Hurts and running back Saquon Barkley did not play in the game.
This season, Hurts has thrown for 3,224 yards and has completed 65% of his passes. He has thrown for 25 touchdowns and six interceptions. Barkley has rushed for 1,140 yards and seven touchdowns, too. DeVonta Smith and AJ Brown have both caught over 1,000 yards with a combined 11 touchdowns.
On defense, Zack Baun leads the team with 123 tackles. Jalyx Hunt has a team-high 6.5 sacks while Moro Ojomo has six sacks, too. The defense has forced 21 turnovers with Hunt securing a team-high three interceptions.
This is the first meeting of the year between the Eagles and the 49ers.
Philadelphia is averaging 22.3 points per game, which ranks 19th. They are the 18th ranked rush offense averaging 116.9 yards per game. The Eagles are the 23rd ranked passing offense averaging 194.3 yards per game.
On defense, the Eagles are allowing 19.1 points per game, which ranks fifth-best. They are the eighth ranked pass defense allowing 189.8 yards per game. Philadelphia is allowing 124.4 rushing yards per game, which ranks 22nd.
Philadelphia is 10-7 against the spread this season. The Eagles are 4-4 against the spread when they have played at home. They are 4-3 against the spread when they have been favored by 6 points or more. The under is 10-7 when the Eagles have played this year. The under is 5-3 when the Eagles have played at home. The under is 4-2 when the total has been set at 44 points or more this season.
Key injuries
- OT Lane Johnson (foot), questionable
- LB Azeez Ojulari (hamstring), questionable
- G Brett Toth (concussion), questionable
San Francisco 49ers vs Philadelphia Eagles Picks
| # | Handicapper | Profit |
|---|---|---|
| 1 |  The Insiders Room | +1,793.00 |
| 2 |  Tony Karpinski | +1,731.00 |
| 3 |  Jesse Schule | +1,599.00 |
| 4 |  Rob Vinciletti | +1,284.00 |
| 5 |  David Delano | +1,232.00 |
49ers vs Eagles Spread Pick
- Philadelphia Eagles -6 (5 units)
The Eagles rested their star players last week and they should be well rested for the opening game of the playoffs. Philadelphia has the players to make another Super Bowl run through strong offense and defense. The Eagles defense is one of the best as they allow the fifth-fewest points per game. They are also the eighth-best pass defense, which will cause the 49ers problems. Seattle exposed San Francisco’s poor offense as they struggled last week in a big time game. The 49ers are struggling with injuries and this could be a game where fatigue becomes a factor. Philadelphia’s home field advantage along with their strong defense will be a major difference in a low scoring game where Saquon Barkley shines.
Take the Eagles to cover.
49ers vs Eagles Over/Under Pick
- Under 44 (5 units)
Both teams rely on the run, and deservedly so. Saquon Barkley leads the Eagles, while Christian McCaffrey is the main guy for the 49ers. While relying on the run, the clock will tick and long possessions are bound to happen. The two teams also pride themselves on defense, with the Eagles having the fifth-best scoring defense. The 49ers are also allowing under 22 points per game, too. Two teams with strong defenses and rushing attacks should make for a low scoring game. The under is 5-3 when the Eagles have played at home. The under is 4-2 when the total has been set at 44 points or more this season for Philadelphia.
Take the under on Sunday.
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